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Ulcerative Colitis-Associated Colorectal Adenocarcinoma

MedGen UID:
474453
•Concept ID:
C3272820
•
Neoplastic Process
Synonyms: UC-Associated CRC; Ulcerative Colitis-Associated Colorectal Carcinoma

Definition

A colorectal adenocarcinoma that develops in patients with a history of ulcerative colitis. Such carcinomas are usually multiple and flat. Histologically, they are usually mucinous or signet-ring cell type. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUlcerative Colitis-Associated Colorectal Adenocarcinoma

Recent clinical studies

Etiology

Histological differentiation between sporadic and colitis-associated intestinal cancer in a nationwide study: A propensity-score-matched analysis.
Uchino M, Ikeuchi H, Noguchi T, Okabayashi K, Futami K, Tanaka S, Ohge H, Watanabe K, Itabashi M, Okamoto K, Okita Y, Mizushima T, Mizuuchi Y, Yamada K, Shimada Y, Sato Y, Kimura H, Takahashi K, Hida K, Kinugasa Y, Okuda J, Daito K, Koyama F, Ueno H, Yamamoto T, Hanai T, Kono T, Kobayashi H, Ajioka Y, Sugihara K, Ishihara S; Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers of the Japanese Society for Cancer of the Colon and Rectum
J Gastroenterol Hepatol 2024 May;39(5):893-901. Epub 2024 Jan 25 doi: 10.1111/jgh.16496. PMID: 38273469
Surgical resections of ulcerative colitis associated with dysplasia or carcinoma.
Sameshima S, Koketsu S, Takeshita E, Kubota Y, Okuyama T, Saito K, Ueda Y, Sawada T, Oya M
World J Surg Oncol 2015 Feb 21;13:70. doi: 10.1186/s12957-015-0499-4. PMID: 25884202Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.
Oka S, Tanaka S, Chayama K
Gastrointest Endosc Clin N Am 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011. PMID: 24975531
Inflammatory bowel disease and colon cancer.
Jawad N, Direkze N, Leedham SJ
Recent Results Cancer Res 2011;185:99-115. doi: 10.1007/978-3-642-03503-6_6. PMID: 21822822

Diagnosis

Histological differentiation between sporadic and colitis-associated intestinal cancer in a nationwide study: A propensity-score-matched analysis.
Uchino M, Ikeuchi H, Noguchi T, Okabayashi K, Futami K, Tanaka S, Ohge H, Watanabe K, Itabashi M, Okamoto K, Okita Y, Mizushima T, Mizuuchi Y, Yamada K, Shimada Y, Sato Y, Kimura H, Takahashi K, Hida K, Kinugasa Y, Okuda J, Daito K, Koyama F, Ueno H, Yamamoto T, Hanai T, Kono T, Kobayashi H, Ajioka Y, Sugihara K, Ishihara S; Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers of the Japanese Society for Cancer of the Colon and Rectum
J Gastroenterol Hepatol 2024 May;39(5):893-901. Epub 2024 Jan 25 doi: 10.1111/jgh.16496. PMID: 38273469
The molecular landscape of colitis-associated carcinogenesis.
Saraggi D, Fassan M, Mescoli C, Scarpa M, Valeri N, Michielan A, D'Incá R, Rugge M
Dig Liver Dis 2017 Apr;49(4):326-330. Epub 2016 Dec 21 doi: 10.1016/j.dld.2016.12.011. PMID: 28089111
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.
Oka S, Tanaka S, Chayama K
Gastrointest Endosc Clin N Am 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011. PMID: 24975531
Inflammatory bowel disease and colon cancer.
Jawad N, Direkze N, Leedham SJ
Recent Results Cancer Res 2011;185:99-115. doi: 10.1007/978-3-642-03503-6_6. PMID: 21822822

Therapy

Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer.
Yoon YS, Cho YB, Park KJ, Baik SH, Yoon SN, Ryoo SB, Lee KY, Kim H, Lee RA, Yu CS; IBD Study Group; Korean Society of Coloproctology
World J Gastroenterol 2015 Mar 28;21(12):3547-53. doi: 10.3748/wjg.v21.i12.3547. PMID: 25834319Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.
Oka S, Tanaka S, Chayama K
Gastrointest Endosc Clin N Am 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011. PMID: 24975531
The role of chemoprevention of colorectal cancer with 5-aminosalicylates in ulcerative colitis.
Herfarth H
Dig Dis 2012;30 Suppl 2:55-9. Epub 2012 Nov 23 doi: 10.1159/000341894. PMID: 23207933
Cancer in inflammatory bowel disease.
Xie J, Itzkowitz SH
World J Gastroenterol 2008 Jan 21;14(3):378-89. doi: 10.3748/wjg.14.378. PMID: 18200660Free PMC Article

Prognosis

TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity.
Lian Q, Yan S, Yin Q, Yan C, Zheng W, Gu W, Zhao X, Fan W, Li X, Ma L, Ling Z, Zhang Y, Liu J, Li J, Sun B
Cell Mol Immunol 2021 Feb;18(2):350-362. Epub 2020 Feb 24 doi: 10.1038/s41423-020-0366-2. PMID: 32094504Free PMC Article
The molecular landscape of colitis-associated carcinogenesis.
Saraggi D, Fassan M, Mescoli C, Scarpa M, Valeri N, Michielan A, D'Incá R, Rugge M
Dig Liver Dis 2017 Apr;49(4):326-330. Epub 2016 Dec 21 doi: 10.1016/j.dld.2016.12.011. PMID: 28089111
Prognosis of Ulcerative Colitis-Associated Colorectal Carcinoma Compared to Sporadic Colorectal Carcinoma: A Matched Pair Analysis.
Leowardi C, Schneider ML, Hinz U, Harnoss JM, Tarantino I, Lasitschka F, Ulrich A, Büchler MW, Kadmon M
Ann Surg Oncol 2016 Mar;23(3):870-6. Epub 2015 Oct 14 doi: 10.1245/s10434-015-4915-3. PMID: 26467453
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Inflammatory bowel disease and colon cancer.
Jawad N, Direkze N, Leedham SJ
Recent Results Cancer Res 2011;185:99-115. doi: 10.1007/978-3-642-03503-6_6. PMID: 21822822

Clinical prediction guides

Histological differentiation between sporadic and colitis-associated intestinal cancer in a nationwide study: A propensity-score-matched analysis.
Uchino M, Ikeuchi H, Noguchi T, Okabayashi K, Futami K, Tanaka S, Ohge H, Watanabe K, Itabashi M, Okamoto K, Okita Y, Mizushima T, Mizuuchi Y, Yamada K, Shimada Y, Sato Y, Kimura H, Takahashi K, Hida K, Kinugasa Y, Okuda J, Daito K, Koyama F, Ueno H, Yamamoto T, Hanai T, Kono T, Kobayashi H, Ajioka Y, Sugihara K, Ishihara S; Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers of the Japanese Society for Cancer of the Colon and Rectum
J Gastroenterol Hepatol 2024 May;39(5):893-901. Epub 2024 Jan 25 doi: 10.1111/jgh.16496. PMID: 38273469
Establishment of a Novel Colitis-Associated Cancer Mouse Model Showing Flat Invasive Neoplasia.
Uragami T, Ando Y, Aoi M, Fukui T, Matsumoto Y, Horitani S, Tomiyama T, Okazaki K, Tsuneyama K, Tanaka H, Naganuma M
Dig Dis Sci 2023 May;68(5):1885-1893. Epub 2022 Dec 11 doi: 10.1007/s10620-022-07774-4. PMID: 36504013
Clinical usefulness of endoscopic ultrasonography for the evaluation of ulcerative colitis-associated tumors.
Kobayashi K, Kawagishi K, Ooka S, Yokoyama K, Sada M, Koizumi W
World J Gastroenterol 2015 Mar 7;21(9):2693-9. doi: 10.3748/wjg.v21.i9.2693. PMID: 25759538Free PMC Article
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
The role of chemoprevention of colorectal cancer with 5-aminosalicylates in ulcerative colitis.
Herfarth H
Dig Dis 2012;30 Suppl 2:55-9. Epub 2012 Nov 23 doi: 10.1159/000341894. PMID: 23207933

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