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Colon serrated polyposis

MedGen UID:
474430
Concept ID:
C3272797
Disease or Syndrome
Synonyms: Colon Serrated Polyposis; colon serrated polyposis
 
Monarch Initiative: MONDO:0100290

Definition

The presence of multiple serrated polyps in the colon. The polyps are predominantly sessile serrated adenomas/polyps. A minority of the polyps are microvesicular variants of hyperplastic polyps. According to some authors, the polyps are proximal to the sigmoid colon. According to others, the polyps are distributed throughout the entire colon. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon serrated polyposis

Professional guidelines

PubMed

Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article

Recent clinical studies

Etiology

Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
Plevová P
Klin Onkol 2019 Summer;32(Supplementum2):97-108. doi: 10.14735/amko2019S97. PMID: 31409085
Valle L, de Voer RM, Goldberg Y, Sjursen W, Försti A, Ruiz-Ponte C, Caldés T, Garré P, Olsen MF, Nordling M, Castellvi-Bel S, Hemminki K
Mol Aspects Med 2019 Oct;69:10-26. Epub 2019 Mar 18 doi: 10.1016/j.mam.2019.03.001. PMID: 30862463
Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA
Pathology 2018 Jan;50(1):49-59. Epub 2017 Nov 21 doi: 10.1016/j.pathol.2017.09.004. PMID: 29169633
Wells K, Wise PE
Surg Clin North Am 2017 Jun;97(3):605-625. doi: 10.1016/j.suc.2017.01.009. PMID: 28501250

Diagnosis

Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
Hampel H, Kalady MF, Pearlman R, Stanich PP
Hematol Oncol Clin North Am 2022 Jun;36(3):429-447. Epub 2022 May 13 doi: 10.1016/j.hoc.2022.02.002. PMID: 35577708
Murphy A, Solomons J, Risby P, Gabriel J, Bedenham T, Johnson M, Atkinson N, Bailey AA, Bird-Lieberman E, Leedham SJ, East JE, Biswas S
J Gastroenterol Hepatol 2022 May;37(5):861-869. Epub 2022 Feb 18 doi: 10.1111/jgh.15791. PMID: 35128723Free PMC Article
van Toledo DEFWM, IJspeert JEG, Dekker E
Annu Rev Med 2022 Jan 27;73:293-306. doi: 10.1146/annurev-med-042220-024703. PMID: 35084990
Gupta N, Drogan C, Kupfer SS
Curr Opin Gastroenterol 2022 Jan 1;38(1):39-47. doi: 10.1097/MOG.0000000000000796. PMID: 34839308Free PMC Article

Therapy

Kanth P, Hazel MW, Schell JC, Rutter J, Yao R, Mills AP, Delker DA
Fam Cancer 2024 Nov;23(4):479-489. Epub 2024 Apr 12 doi: 10.1007/s10689-024-00370-7. PMID: 38609520Free PMC Article
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Muller C, Yamada A, Ikegami S, Haider H, Komaki Y, Komaki F, Micic D, Sakuraba A
Clin Gastroenterol Hepatol 2022 Mar;20(3):622-630.e7. Epub 2021 Jun 2 doi: 10.1016/j.cgh.2021.05.057. PMID: 34089849
Cauley CE, Hassab TH, Feinberg A, Church J
Dis Colon Rectum 2020 Feb;63(2):183-189. doi: 10.1097/DCR.0000000000001537. PMID: 31914111
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article

Prognosis

Muller C, Yamada A, Ikegami S, Haider H, Komaki Y, Komaki F, Micic D, Sakuraba A
Clin Gastroenterol Hepatol 2022 Mar;20(3):622-630.e7. Epub 2021 Jun 2 doi: 10.1016/j.cgh.2021.05.057. PMID: 34089849
Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, Law WL, Lo OSH, Yuen ST, Clevers H, Leung SY
Gut 2020 Dec;69(12):2165-2179. Epub 2020 Mar 26 doi: 10.1136/gutjnl-2019-320019. PMID: 32217638
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Anthony E, Reece JC, Milanzi E, Joo JE, Joseland S, Clendenning M, Whelan A, Parry S, Arnold J, Vijay V, Atkinson N, Hopper JL, Win AK, Jenkins MA, Macrae FA, Winship IM, Rosty C, Buchanan DD; Australasian Coloretal Cancer Family Registry; Family Cancer Clinics of Australia; Genetics of Colonic Polyposis Study
BMC Gastroenterol 2022 Nov 26;22(1):489. doi: 10.1186/s12876-022-02557-7. PMID: 36435745Free PMC Article
Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, Law WL, Lo OSH, Yuen ST, Clevers H, Leung SY
Gut 2020 Dec;69(12):2165-2179. Epub 2020 Mar 26 doi: 10.1136/gutjnl-2019-320019. PMID: 32217638
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article

Recent systematic reviews

Muller C, Yamada A, Ikegami S, Haider H, Komaki Y, Komaki F, Micic D, Sakuraba A
Clin Gastroenterol Hepatol 2022 Mar;20(3):622-630.e7. Epub 2021 Jun 2 doi: 10.1016/j.cgh.2021.05.057. PMID: 34089849

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