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Axial spondyloarthritis

MedGen UID:
923672
•Concept ID:
C3203547
•
Disease or Syndrome
Synonyms: Axial Spondyloarthritides; Axial Spondyloarthritis; AxSpA; Spondyloarthritides, Axial; Spondyloarthritis, Axial
SNOMED CT: Axial spondyloarthritis (723116002)

Definition

A spectrum of chronic inflammatory conditions affecting the axial joints (e.g., SPINE), characterized by pain, stiffness of joints (ANKYLOSIS), reduced mobility and inflammation. When joint inflammation and damage are visible on regular X-rays it is called ANKYLOSING SPONDYLITIS; otherwise it is referred to as NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS. HLA-B27 ANTIGEN is a biomarker and IL-23/IL-17 pathway a potential therapeutic target for axial and other related spondyloarthritis. [from MeSH]

Professional guidelines

PubMed

ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article

Recent clinical studies

Etiology

Structural disease modification in axial spondyloarthritis.
Dinneen B, O'Shea F, Gensler L
Best Pract Res Clin Rheumatol 2023 Sep;37(3):101898. Epub 2023 Dec 1 doi: 10.1016/j.berh.2023.101898. PMID: 38042689
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Classification vs diagnostic criteria: the challenge of diagnosing axial spondyloarthritis.
Poddubnyy D
Rheumatology (Oxford) 2020 Oct 1;59(Suppl4):iv6-iv17. doi: 10.1093/rheumatology/keaa250. PMID: 33053191Free PMC Article
Epidemiology of axial spondyloarthritis: an update.
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Genetics and the Causes of Ankylosing Spondylitis.
Hanson A, Brown MA
Rheum Dis Clin North Am 2017 Aug;43(3):401-414. doi: 10.1016/j.rdc.2017.04.006. PMID: 28711142Free PMC Article

Diagnosis

Challenges in the diagnosis of axial spondyloarthritis.
van Gaalen FA, Rudwaleit M
Best Pract Res Clin Rheumatol 2023 Sep;37(3):101871. Epub 2023 Sep 14 doi: 10.1016/j.berh.2023.101871. PMID: 37714776
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.
Walsh JA, Magrey M
J Clin Rheumatol 2021 Dec 1;27(8):e547-e560. doi: 10.1097/RHU.0000000000001575. PMID: 33105312Free PMC Article
Axial spondyloarthritis.
Sieper J, Poddubnyy D
Lancet 2017 Jul 1;390(10089):73-84. Epub 2017 Jan 20 doi: 10.1016/S0140-6736(16)31591-4. PMID: 28110981

Therapy

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Management of Axial Spondyloarthritis - Insights into Upadacitinib.
Braun J, Kiltz U, Baraliakos X
Drug Des Devel Ther 2022;16:3609-3620. Epub 2022 Oct 19 doi: 10.2147/DDDT.S330413. PMID: 36268520Free PMC Article
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article

Prognosis

Immune-mediated inflammatory diseases: Common and different pathogenic and clinical features.
Monteleone G, Moscardelli A, Colella A, Marafini I, Salvatori S
Autoimmun Rev 2023 Oct;22(10):103410. Epub 2023 Aug 18 doi: 10.1016/j.autrev.2023.103410. PMID: 37597601
Axial involvement in psoriatic arthritis: An update for rheumatologists.
Poddubnyy D, Jadon DR, Van den Bosch F, Mease PJ, Gladman DD
Semin Arthritis Rheum 2021 Aug;51(4):880-887. Epub 2021 Jun 19 doi: 10.1016/j.semarthrit.2021.06.006. PMID: 34198146
Clinical Manifestations and Diagnosis of Axial Spondyloarthritis.
Walsh JA, Magrey M
J Clin Rheumatol 2021 Dec 1;27(8):e547-e560. doi: 10.1097/RHU.0000000000001575. PMID: 33105312Free PMC Article
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Clinical prediction guides

Serum biomarkers and their relationship to axial spondyloarthritis associated with inflammatory bowel diseases.
Ondrejčáková L, Gregová M, Bubová K, Šenolt L, Pavelka K
Autoimmun Rev 2024 Mar;23(3):103512. Epub 2023 Dec 31 doi: 10.1016/j.autrev.2023.103512. PMID: 38168574
Emerging Concepts in Precision Medicine in Axial Spondyloarthritis.
Allard-Chamard H, Li Q, Rahman P
Curr Rheumatol Rep 2023 Oct;25(10):204-212. Epub 2023 Jul 28 doi: 10.1007/s11926-023-01113-w. PMID: 37505349
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Biomarker development for axial spondyloarthritis.
Brown MA, Li Z, Cao KL
Nat Rev Rheumatol 2020 Aug;16(8):448-463. Epub 2020 Jun 30 doi: 10.1038/s41584-020-0450-0. PMID: 32606474
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971

Recent systematic reviews

EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update.
Gossec L, Kerschbaumer A, Ferreira RJO, Aletaha D, Baraliakos X, Bertheussen H, Boehncke WH, Esbensen BA, McInnes IB, McGonagle D, Winthrop KL, Balanescu A, Balint PV, Burmester GR, Cañete JD, Claudepierre P, Eder L, Hetland ML, Iagnocco A, Kristensen LE, Lories R, Queiro R, Mauro D, Marzo-Ortega H, Mease PJ, Nash P, Wagenaar W, Savage L, Schett G, Shoop-Worrall SJW, Tanaka Y, Van den Bosch FE, van der Helm-van Mil A, Zabotti A, van der Heijde D, Smolen JS
Ann Rheum Dis 2024 May 15;83(6):706-719. doi: 10.1136/ard-2024-225531. PMID: 38499325Free PMC Article
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Efficacy and safety of non-pharmacological and non-biological interventions: a systematic literature review informing the 2022 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis.
Ortolan A, Webers C, Sepriano A, Falzon L, Baraliakos X, Landewé RB, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):142-152. Epub 2022 Oct 19 doi: 10.1136/ard-2022-223297. PMID: 36261247
Ankylosing spondylitis risk factors: a systematic literature review.
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article

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