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Acute repetitive seizure

MedGen UID:
1663064
•Concept ID:
C3203523
•
Disease or Syndrome
Synonym: Recurrent seizures
SNOMED CT: Cluster seizure (460681000124100); Serial seizure (460681000124100); Acute repetitive seizure (460681000124100); Recurrent seizure (460731000124105); Crescendo seizure (460681000124100)

Professional guidelines

PubMed

Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis.
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL; DIAZ.001.05 Study Group
Epilepsia 2022 Jul;63(7):1714-1723. Epub 2022 Apr 19 doi: 10.1111/epi.17249. PMID: 35377464Free PMC Article

Recent clinical studies

Etiology

Acute Abortive Therapies for Seizure Clusters in Long-Term Care.
Ramsay RE, Becker DA, Vazquez B, Birnbaum AK, Misra SN, Carrazana E, Rabinowicz AL
J Am Med Dir Assoc 2023 Aug;24(8):1225-1232. Epub 2023 May 27 doi: 10.1016/j.jamda.2023.04.015. PMID: 37253432
Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study.
Peters JM, Puri V, Segal E, Misra SN, Rabinowicz AL, Carrazana E
Epilepsy Behav 2023 Jul;144:109248. Epub 2023 May 19 doi: 10.1016/j.yebeh.2023.109248. PMID: 37210793
Recognizing seizure clusters in the community: The path to uniformity and individualization in nomenclature and definition.
Haut SR, Nabbout R
Epilepsia 2022 Sep;63 Suppl 1:S6-S13. doi: 10.1111/epi.17346. PMID: 35999176
Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis.
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL; DIAZ.001.05 Study Group
Epilepsia 2022 Jul;63(7):1714-1723. Epub 2022 Apr 19 doi: 10.1111/epi.17249. PMID: 35377464Free PMC Article
Efficacy of oral perampanel in status epilepticus and acute repetitive seizures in children at a tertiary care hospital in Thailand.
Wachiropathum P, Nabangchang C, Likasitthananon N, Suwanpakdee P
Epilepsy Behav 2021 May;118:107964. Epub 2021 Apr 16 doi: 10.1016/j.yebeh.2021.107964. PMID: 33866126

Diagnosis

Intracerebral electrographic activity following a single dose of diazepam nasal spray: A pilot study.
Privitera MD, Mendoza LC, Carrazana E, Rabinowicz AL
Epilepsia Open 2024 Feb;9(1):380-387. Epub 2024 Jan 4 doi: 10.1002/epi4.12890. PMID: 38131286Free PMC Article
Recognizing seizure clusters in the community: The path to uniformity and individualization in nomenclature and definition.
Haut SR, Nabbout R
Epilepsia 2022 Sep;63 Suppl 1:S6-S13. doi: 10.1111/epi.17346. PMID: 35999176
Quality-of-life results in adults with epilepsy using diazepam nasal spray for seizure clusters from a long-term, open-label safety study.
Cramer JA, Faught E, Davis C, Misra SN, Carrazana E, Rabinowicz AL
Epilepsy Behav 2022 Sep;134:108811. Epub 2022 Jul 8 doi: 10.1016/j.yebeh.2022.108811. PMID: 35816831
Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy.
Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group
Epilepsia 2021 Oct;62(10):2485-2495. Epub 2021 Aug 21 doi: 10.1111/epi.17041. PMID: 34418086Free PMC Article
Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial.
Spencer DC, Sinha SR, Choi EJ, Cleveland JM, King A, Meng TC, Pullman WE, Sequeira DJ, Van Ess PJ, Wheless JW
Epilepsia 2020 Nov;61(11):2415-2425. Epub 2020 Nov 2 doi: 10.1111/epi.16704. PMID: 33140403

Therapy

Acute Abortive Therapies for Seizure Clusters in Long-Term Care.
Ramsay RE, Becker DA, Vazquez B, Birnbaum AK, Misra SN, Carrazana E, Rabinowicz AL
J Am Med Dir Assoc 2023 Aug;24(8):1225-1232. Epub 2023 May 27 doi: 10.1016/j.jamda.2023.04.015. PMID: 37253432
Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study.
Peters JM, Puri V, Segal E, Misra SN, Rabinowicz AL, Carrazana E
Epilepsy Behav 2023 Jul;144:109248. Epub 2023 May 19 doi: 10.1016/j.yebeh.2023.109248. PMID: 37210793
Rescue Treatments for Seizure Clusters.
Kotloski RJ, Gidal BE
Neurol Clin 2022 Nov;40(4):927-937. Epub 2022 Sep 28 doi: 10.1016/j.ncl.2022.03.016. PMID: 36270699
Recognizing seizure clusters in the community: The path to uniformity and individualization in nomenclature and definition.
Haut SR, Nabbout R
Epilepsia 2022 Sep;63 Suppl 1:S6-S13. doi: 10.1111/epi.17346. PMID: 35999176
Efficacy of oral perampanel in status epilepticus and acute repetitive seizures in children at a tertiary care hospital in Thailand.
Wachiropathum P, Nabangchang C, Likasitthananon N, Suwanpakdee P
Epilepsy Behav 2021 May;118:107964. Epub 2021 Apr 16 doi: 10.1016/j.yebeh.2021.107964. PMID: 33866126

Prognosis

Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis.
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL; DIAZ.001.05 Study Group
Epilepsia 2022 Jul;63(7):1714-1723. Epub 2022 Apr 19 doi: 10.1111/epi.17249. PMID: 35377464Free PMC Article

Clinical prediction guides

Quality-of-life results in adults with epilepsy using diazepam nasal spray for seizure clusters from a long-term, open-label safety study.
Cramer JA, Faught E, Davis C, Misra SN, Carrazana E, Rabinowicz AL
Epilepsy Behav 2022 Sep;134:108811. Epub 2022 Jul 8 doi: 10.1016/j.yebeh.2022.108811. PMID: 35816831
Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis.
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL; DIAZ.001.05 Study Group
Epilepsia 2022 Jul;63(7):1714-1723. Epub 2022 Apr 19 doi: 10.1111/epi.17249. PMID: 35377464Free PMC Article
Consistent safety and tolerability of Valtoco(®) (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long-term, open-label, repeat-dose safety study.
Miller I, Wheless JW, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group
Epilepsia Open 2021 Sep;6(3):504-512. Epub 2021 May 13 doi: 10.1002/epi4.12494. PMID: 34033266Free PMC Article
Efficacy of oral perampanel in status epilepticus and acute repetitive seizures in children at a tertiary care hospital in Thailand.
Wachiropathum P, Nabangchang C, Likasitthananon N, Suwanpakdee P
Epilepsy Behav 2021 May;118:107964. Epub 2021 Apr 16 doi: 10.1016/j.yebeh.2021.107964. PMID: 33866126
Safety and efficacy of midazolam nasal spray for the treatment of intermittent bouts of increased seizure activity in the epilepsy monitoring unit: A double-blind, randomized, placebo-controlled trial.
Spencer DC, Sinha SR, Choi EJ, Cleveland JM, King A, Meng TC, Pullman WE, Sequeira DJ, Van Ess PJ, Wheless JW
Epilepsia 2020 Nov;61(11):2415-2425. Epub 2020 Nov 2 doi: 10.1111/epi.16704. PMID: 33140403

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