U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pain Amplification Syndrome

MedGen UID:
465257
•Concept ID:
C3178789
•
Disease or Syndrome
Synonyms: Chronic Pain, Widespread; Pain, Widespread Chronic; Widespread Chronic Pain

Definition

A condition in which the nerves register normal stimuli (lack of tissue injury) as pain, resulting in feelings of intense pain with even minor sensory input. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPain Amplification Syndrome

Professional guidelines

PubMed

Chronic Pain: Prevalence and Management.
Carroll CP, Brandow AM
Hematol Oncol Clin North Am 2022 Dec;36(6):1151-1165. doi: 10.1016/j.hoc.2022.06.009. PMID: 36400536
CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.
Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R
MMWR Recomm Rep 2022 Nov 4;71(3):1-95. doi: 10.15585/mmwr.rr7103a1. PMID: 36327391Free PMC Article
Chronic Pain Management in the Elderly.
Schwan J, Sclafani J, Tawfik VL
Anesthesiol Clin 2019 Sep;37(3):547-560. Epub 2019 Jun 18 doi: 10.1016/j.anclin.2019.04.012. PMID: 31337484Free PMC Article

Recent clinical studies

Etiology

Assessing our approach to diagnosing Fibromyalgia.
Hackshaw K
Expert Rev Mol Diagn 2020 Dec;20(12):1171-1181. Epub 2020 Dec 10 doi: 10.1080/14737159.2020.1858054. PMID: 33301346
A case-control study about bite force, symptoms and signs of temporomandibular disorders in patients with idiopathic musculoskeletal pain syndromes.
Zwir L, Fraga M, Sanches M, Hoyuela C, Len C, Terreri MT
Adv Rheumatol 2018 Jun 19;58(1):7. doi: 10.1186/s42358-018-0006-z. PMID: 30657076
Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate.
Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE
Eur J Pediatr 2010 Sep;169(9):1105-11. Epub 2010 Mar 27 doi: 10.1007/s00431-010-1188-5. PMID: 20339868
Five-year outcome of children with "growing pains": correlations with pain threshold.
Uziel Y, Chapnick G, Jaber L, Nemet D, Hashkes PJ
J Pediatr 2010 May;156(5):838-40. Epub 2010 Feb 20 doi: 10.1016/j.jpeds.2009.11.078. PMID: 20171654

Diagnosis

Assessing our approach to diagnosing Fibromyalgia.
Hackshaw K
Expert Rev Mol Diagn 2020 Dec;20(12):1171-1181. Epub 2020 Dec 10 doi: 10.1080/14737159.2020.1858054. PMID: 33301346
Pediatric Pain Syndromes and Noninflammatory Musculoskeletal Pain.
Weiss JE, Stinson JN
Pediatr Clin North Am 2018 Aug;65(4):801-826. doi: 10.1016/j.pcl.2018.04.004. PMID: 30031499
Pain Amplification Syndrome: A Biopsychosocial Approach.
Namerow LB, Kutner EC, Wakefield EC, Rzepski BR, Sahl RA
Semin Pediatr Neurol 2016 Aug;23(3):224-230. Epub 2016 Oct 20 doi: 10.1016/j.spen.2016.10.006. PMID: 27989330
Pediatric complex regional pain syndrome: a review.
Weissmann R, Uziel Y
Pediatr Rheumatol Online J 2016 Apr 29;14(1):29. doi: 10.1186/s12969-016-0090-8. PMID: 27130211Free PMC Article
Fibrositis (fibromyalgia). A common non-entity?
Hart FD
Drugs 1988 Mar;35(3):320-7. doi: 10.2165/00003495-198835030-00006. PMID: 3286215

Therapy

Capsaicin: Plants of the Genus Capsicum and Positive Effect of Oriental Spice on Skin Health.
Basharat S, Gilani SA, Iftikhar F, Murtaza MA, Basharat A, Sattar A, Qamar MM, Ali M
Skin Pharmacol Physiol 2020;33(6):331-341. Epub 2021 Jan 5 doi: 10.1159/000512196. PMID: 33401283
A case-control study about bite force, symptoms and signs of temporomandibular disorders in patients with idiopathic musculoskeletal pain syndromes.
Zwir L, Fraga M, Sanches M, Hoyuela C, Len C, Terreri MT
Adv Rheumatol 2018 Jun 19;58(1):7. doi: 10.1186/s42358-018-0006-z. PMID: 30657076
Pediatric Pain Syndromes and Noninflammatory Musculoskeletal Pain.
Weiss JE, Stinson JN
Pediatr Clin North Am 2018 Aug;65(4):801-826. doi: 10.1016/j.pcl.2018.04.004. PMID: 30031499
Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate.
Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE
Eur J Pediatr 2010 Sep;169(9):1105-11. Epub 2010 Mar 27 doi: 10.1007/s00431-010-1188-5. PMID: 20339868
Current experience with 5-HT3 receptor antagonists in fibromyalgia.
Späth M
Rheum Dis Clin North Am 2002 May;28(2):319-28. doi: 10.1016/s0889-857x(01)00014-x. PMID: 12122920

Prognosis

Pediatric complex regional pain syndrome: a review.
Weissmann R, Uziel Y
Pediatr Rheumatol Online J 2016 Apr 29;14(1):29. doi: 10.1186/s12969-016-0090-8. PMID: 27130211Free PMC Article
Five-year outcome of children with "growing pains": correlations with pain threshold.
Uziel Y, Chapnick G, Jaber L, Nemet D, Hashkes PJ
J Pediatr 2010 May;156(5):838-40. Epub 2010 Feb 20 doi: 10.1016/j.jpeds.2009.11.078. PMID: 20171654
Fibrositis (fibromyalgia). A common non-entity?
Hart FD
Drugs 1988 Mar;35(3):320-7. doi: 10.2165/00003495-198835030-00006. PMID: 3286215

Clinical prediction guides

Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate.
Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE
Eur J Pediatr 2010 Sep;169(9):1105-11. Epub 2010 Mar 27 doi: 10.1007/s00431-010-1188-5. PMID: 20339868
Current experience with 5-HT3 receptor antagonists in fibromyalgia.
Späth M
Rheum Dis Clin North Am 2002 May;28(2):319-28. doi: 10.1016/s0889-857x(01)00014-x. PMID: 12122920
Fibrositis (fibromyalgia). A common non-entity?
Hart FD
Drugs 1988 Mar;35(3):320-7. doi: 10.2165/00003495-198835030-00006. PMID: 3286215

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...