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Dysplastic nodule

MedGen UID:
756371
•Concept ID:
C3163961
•
Anatomical Abnormality
SNOMED CT: Dysplastic nodule (448149008)

Professional guidelines

PubMed

Primary Liver Cancers-Part 1: Histopathology, Differential Diagnoses, and Risk Stratification.
Jiang K, Al-Diffhala S, Centeno BA
Cancer Control 2018 Jan-Mar;25(1):1073274817744625. doi: 10.1177/1073274817744625. PMID: 29350068Free PMC Article
Early detection and curative treatment of early-stage hepatocellular carcinoma.
Kudo M
Clin Gastroenterol Hepatol 2005 Oct;3(10 Suppl 2):S144-8. doi: 10.1016/s1542-3565(05)00712-3. PMID: 16234064
Differential diagnosis of hepatocellular nodular lesions.
Hytiroglou P, Theise ND
Semin Diagn Pathol 1998 Nov;15(4):285-99. PMID: 9845429

Recent clinical studies

Etiology

Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma.
Wen KW, Kakar S
Gastroenterol Clin North Am 2024 Mar;53(1):109-132. Epub 2023 Dec 16 doi: 10.1016/j.gtc.2023.11.005. PMID: 38280744
Differentiation of regenerative nodule, dysplastic nodule, and small hepatocellular carcinoma in cirrhotic patients: a contrast-enhanced ultrasound-based multivariable model analysis.
Duan Y, Xie X, Li Q, Mercaldo N, Samir AE, Kuang M, Lin M
Eur Radiol 2020 Sep;30(9):4741-4751. Epub 2020 Apr 19 doi: 10.1007/s00330-020-06834-5. PMID: 32307563
Latest developments in precancerous lesions of hepatocellular carcinoma.
Niu ZS, Niu XJ, Wang WH, Zhao J
World J Gastroenterol 2016 Mar 28;22(12):3305-14. doi: 10.3748/wjg.v22.i12.3305. PMID: 27022212Free PMC Article
Update on precursor and early lesions of hepatocellular carcinomas.
Park YN
Arch Pathol Lab Med 2011 Jun;135(6):704-15. doi: 10.5858/2010-0524-RA.1. PMID: 21631263
Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma.
Sakamoto M, Mori T, Masugi Y, Effendi K, Rie I, Du W
Intervirology 2008;51 Suppl 1:42-5. Epub 2008 Jun 10 doi: 10.1159/000122603. PMID: 18544947

Diagnosis

Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma.
Wen KW, Kakar S
Gastroenterol Clin North Am 2024 Mar;53(1):109-132. Epub 2023 Dec 16 doi: 10.1016/j.gtc.2023.11.005. PMID: 38280744
Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma.
Choi WT, Kakar S
Gastroenterol Clin North Am 2017 Jun;46(2):311-325. doi: 10.1016/j.gtc.2017.01.006. PMID: 28506367
Latest developments in precancerous lesions of hepatocellular carcinoma.
Niu ZS, Niu XJ, Wang WH, Zhao J
World J Gastroenterol 2016 Mar 28;22(12):3305-14. doi: 10.3748/wjg.v22.i12.3305. PMID: 27022212Free PMC Article
Ongoing challenges in the diagnosis of hepatocellular carcinoma.
Terzi E, Salvatore V, Negrini G, Piscaglia F
Expert Rev Gastroenterol Hepatol 2016;10(4):451-63. Epub 2015 Dec 19 doi: 10.1586/17474124.2016.1124758. PMID: 26603785
Diagnosing Borderline Hepatic Nodules in Hepatocarcinogenesis: Imaging Performance.
Choi BI, Lee JM, Kim TK, Dioguardi Burgio M, Vilgrain V
AJR Am J Roentgenol 2015 Jul;205(1):10-21. doi: 10.2214/AJR.14.12655. PMID: 26102378

Therapy

Circulating MicroRNA-122 for the Diagnosis of Hepatocellular Carcinoma: A Meta-Analysis.
Zhao XF, Li N, Lin DD, Sun LB
Biomed Res Int 2020;2020:5353695. Epub 2020 Mar 23 doi: 10.1155/2020/5353695. PMID: 32309434Free PMC Article
Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Liver pathology of hepatitis C, beyond grading and staging of the disease.
Dhingra S, Ward SC, Thung SN
World J Gastroenterol 2016 Jan 28;22(4):1357-66. doi: 10.3748/wjg.v22.i4.1357. PMID: 26819505Free PMC Article
Ongoing challenges in the diagnosis of hepatocellular carcinoma.
Terzi E, Salvatore V, Negrini G, Piscaglia F
Expert Rev Gastroenterol Hepatol 2016;10(4):451-63. Epub 2015 Dec 19 doi: 10.1586/17474124.2016.1124758. PMID: 26603785
Early detection and curative treatment of early-stage hepatocellular carcinoma.
Kudo M
Clin Gastroenterol Hepatol 2005 Oct;3(10 Suppl 2):S144-8. doi: 10.1016/s1542-3565(05)00712-3. PMID: 16234064

Prognosis

Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Latest developments in precancerous lesions of hepatocellular carcinoma.
Niu ZS, Niu XJ, Wang WH, Zhao J
World J Gastroenterol 2016 Mar 28;22(12):3305-14. doi: 10.3748/wjg.v22.i12.3305. PMID: 27022212Free PMC Article
Liver pathology of hepatitis C, beyond grading and staging of the disease.
Dhingra S, Ward SC, Thung SN
World J Gastroenterol 2016 Jan 28;22(4):1357-66. doi: 10.3748/wjg.v22.i4.1357. PMID: 26819505Free PMC Article
Ongoing challenges in the diagnosis of hepatocellular carcinoma.
Terzi E, Salvatore V, Negrini G, Piscaglia F
Expert Rev Gastroenterol Hepatol 2016;10(4):451-63. Epub 2015 Dec 19 doi: 10.1586/17474124.2016.1124758. PMID: 26603785
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM
J Hepatol 2013 Oct;59(4):830-41. Epub 2013 May 7 doi: 10.1016/j.jhep.2013.04.031. PMID: 23665184

Clinical prediction guides

Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475
Liver pathology of hepatitis C, beyond grading and staging of the disease.
Dhingra S, Ward SC, Thung SN
World J Gastroenterol 2016 Jan 28;22(4):1357-66. doi: 10.3748/wjg.v22.i4.1357. PMID: 26819505Free PMC Article
Ongoing challenges in the diagnosis of hepatocellular carcinoma.
Terzi E, Salvatore V, Negrini G, Piscaglia F
Expert Rev Gastroenterol Hepatol 2016;10(4):451-63. Epub 2015 Dec 19 doi: 10.1586/17474124.2016.1124758. PMID: 26603785
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
Frau M, Feo F, Pascale RM
J Hepatol 2013 Oct;59(4):830-41. Epub 2013 May 7 doi: 10.1016/j.jhep.2013.04.031. PMID: 23665184

Recent systematic reviews

Overall diagnostic accuracy of different MR imaging sequences for detection of dysplastic nodules: a systematic review and meta-analysis.
Xiong J, Luo J, Bian J, Wu J
Eur Radiol 2022 Feb;32(2):1285-1296. Epub 2021 Aug 6 doi: 10.1007/s00330-021-08022-5. PMID: 34357448
Circulating MicroRNA-122 for the Diagnosis of Hepatocellular Carcinoma: A Meta-Analysis.
Zhao XF, Li N, Lin DD, Sun LB
Biomed Res Int 2020;2020:5353695. Epub 2020 Mar 23 doi: 10.1155/2020/5353695. PMID: 32309434Free PMC Article

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