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Gastric Hepatoid Adenocarcinoma

MedGen UID:
459622
•Concept ID:
C2987396
•
Neoplastic Process

Definition

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Hepatoid Adenocarcinoma

Professional guidelines

PubMed

Clinicopathologic characteristics and treatment outcomes of hepatoid adenocarcinoma of the stomach, a rare but unique subtype of gastric cancer.
Baek SK, Han SW, Oh DY, Im SA, Kim TY, Bang YJ
BMC Gastroenterol 2011 May 19;11:56. doi: 10.1186/1471-230X-11-56. PMID: 21592404Free PMC Article

Recent clinical studies

Etiology

Prognostic significance of preoperative serum tumor markers in hepatoid adenocarcinoma of stomach (HAS).
Yang X, Wang A, Li J, Zhou K, Ji K, Ji X, Zhang J, Wu X, Bu Z
BMC Cancer 2023 Jan 16;23(1):53. doi: 10.1186/s12885-023-10516-y. PMID: 36647059Free PMC Article
CT-based radiomics nomogram for differentiating gastric hepatoid adenocarcinoma from gastric adenocarcinoma: a multicentre study.
Wang J, Kang B, Sun C, Du F, Lin J, Ding F, Dai Z, Zhang Y, Yang C, Shang L, Li L, Hong Q, Huang C, Wang G
Expert Rev Gastroenterol Hepatol 2023 Feb;17(2):205-214. Epub 2023 Jan 18 doi: 10.1080/17474124.2023.2166490. PMID: 36625225
Gastric Hepatoid Adenocarcinoma: Differentiation From Gastric Adenocarcinoma With Dynamic Contrast-Enhanced Computed Tomographic Findings.
Fu Y, Zhu H, Peng WJ
J Comput Assist Tomogr 2019 Nov/Dec;43(6):887-891. doi: 10.1097/RCT.0000000000000924. PMID: 31490893
Clinicopathologial features of gastric hepatoid adenocarcinoma.
Lin CY, Yeh HC, Hsu CM, Lin WR, Chiu CT
Biomed J 2015 Jan-Feb;38(1):65-9. doi: 10.4103/2319-4170.126860. PMID: 25163499
Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma.
Osada M, Aishima S, Hirahashi M, Takizawa N, Takahashi S, Nakamura K, Tanaka M, Maehara Y, Takayanagi R, Oda Y
Hum Pathol 2014 Jun;45(6):1243-50. Epub 2014 Feb 20 doi: 10.1016/j.humpath.2014.02.003. PMID: 24767858

Diagnosis

Gastric Hepatoid Adenocarcinoma: Differentiation From Gastric Adenocarcinoma With Dynamic Contrast-Enhanced Computed Tomographic Findings.
Fu Y, Zhu H, Peng WJ
J Comput Assist Tomogr 2019 Nov/Dec;43(6):887-891. doi: 10.1097/RCT.0000000000000924. PMID: 31490893
Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature.
Yoshizawa J, Ishizone S, Ikeyama M, Nakayama J
BMC Cancer 2017 May 25;17(1):368. doi: 10.1186/s12885-017-3357-7. PMID: 28545511Free PMC Article
Clinicopathologial features of gastric hepatoid adenocarcinoma.
Lin CY, Yeh HC, Hsu CM, Lin WR, Chiu CT
Biomed J 2015 Jan-Feb;38(1):65-9. doi: 10.4103/2319-4170.126860. PMID: 25163499
Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens.
Yasui W, Oue N, Sentani K, Sakamoto N, Motoshita J
Pathol Int 2009 Mar;59(3):121-36. doi: 10.1111/j.1440-1827.2009.02329.x. PMID: 19261089
Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?
Trompetas V, Varsamidakis N, Frangia K, Polimeropoulos V, Kalokairinos E
Eur J Gastroenterol Hepatol 2003 Nov;15(11):1241-4. doi: 10.1097/00042737-200311000-00015. PMID: 14560160

Therapy

Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature.
Yoshizawa J, Ishizone S, Ikeyama M, Nakayama J
BMC Cancer 2017 May 25;17(1):368. doi: 10.1186/s12885-017-3357-7. PMID: 28545511Free PMC Article
Preliminary study on the clinical and pathological relevance of gastric hepatoid adenocarcinoma.
Gao YB, Zhang DF, Jin XL, Xiao JC
J Dig Dis 2007 Feb;8(1):23-8. doi: 10.1111/j.1443-9573.2007.00279.x. PMID: 17261131
Alpha-fetoprotein-producing gastric cancer mimicking extragonadal testicular cancer.
Becker T, Hegele A, Varga Z, Schwetlick I, Heidenreich A, Hofmann R
Urol Int 2001;66(1):33-5. doi: 10.1159/000056560. PMID: 11150949

Prognosis

CT-based radiomics nomogram for differentiating gastric hepatoid adenocarcinoma from gastric adenocarcinoma: a multicentre study.
Wang J, Kang B, Sun C, Du F, Lin J, Ding F, Dai Z, Zhang Y, Yang C, Shang L, Li L, Hong Q, Huang C, Wang G
Expert Rev Gastroenterol Hepatol 2023 Feb;17(2):205-214. Epub 2023 Jan 18 doi: 10.1080/17474124.2023.2166490. PMID: 36625225
Effect of immune checkpoint inhibitors in patients with gastric hepatoid adenocarcinoma: a case report and literature review.
Sun Y, Chang W, Yao J, Liu H, Zhang X, Wang W, Zhao K
J Int Med Res 2022 Apr;50(4):3000605221091095. doi: 10.1177/03000605221091095. PMID: 35469480Free PMC Article
Gastric Hepatoid Adenocarcinoma: Differentiation From Gastric Adenocarcinoma With Dynamic Contrast-Enhanced Computed Tomographic Findings.
Fu Y, Zhu H, Peng WJ
J Comput Assist Tomogr 2019 Nov/Dec;43(6):887-891. doi: 10.1097/RCT.0000000000000924. PMID: 31490893
Clinicopathologial features of gastric hepatoid adenocarcinoma.
Lin CY, Yeh HC, Hsu CM, Lin WR, Chiu CT
Biomed J 2015 Jan-Feb;38(1):65-9. doi: 10.4103/2319-4170.126860. PMID: 25163499
Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?
Trompetas V, Varsamidakis N, Frangia K, Polimeropoulos V, Kalokairinos E
Eur J Gastroenterol Hepatol 2003 Nov;15(11):1241-4. doi: 10.1097/00042737-200311000-00015. PMID: 14560160

Clinical prediction guides

Prognostic significance of preoperative serum tumor markers in hepatoid adenocarcinoma of stomach (HAS).
Yang X, Wang A, Li J, Zhou K, Ji K, Ji X, Zhang J, Wu X, Bu Z
BMC Cancer 2023 Jan 16;23(1):53. doi: 10.1186/s12885-023-10516-y. PMID: 36647059Free PMC Article
CT-based radiomics nomogram for differentiating gastric hepatoid adenocarcinoma from gastric adenocarcinoma: a multicentre study.
Wang J, Kang B, Sun C, Du F, Lin J, Ding F, Dai Z, Zhang Y, Yang C, Shang L, Li L, Hong Q, Huang C, Wang G
Expert Rev Gastroenterol Hepatol 2023 Feb;17(2):205-214. Epub 2023 Jan 18 doi: 10.1080/17474124.2023.2166490. PMID: 36625225
Gastric Hepatoid Adenocarcinoma: Differentiation From Gastric Adenocarcinoma With Dynamic Contrast-Enhanced Computed Tomographic Findings.
Fu Y, Zhu H, Peng WJ
J Comput Assist Tomogr 2019 Nov/Dec;43(6):887-891. doi: 10.1097/RCT.0000000000000924. PMID: 31490893
Gastric hepatoid adenocarcinoma: a computed tomography report of six cases.
Ren A, Cai F, Shang YN, Ma ES, Huang ZG, Wang W, Luo J
World J Gastroenterol 2014 Oct 28;20(40):15001-6. doi: 10.3748/wjg.v20.i40.15001. PMID: 25356063Free PMC Article
Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?
Trompetas V, Varsamidakis N, Frangia K, Polimeropoulos V, Kalokairinos E
Eur J Gastroenterol Hepatol 2003 Nov;15(11):1241-4. doi: 10.1097/00042737-200311000-00015. PMID: 14560160

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