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Maternal Fever

MedGen UID:
457532
•Concept ID:
C2985306
•
Sign or Symptom

Definition

The elevation of body temperature in a pregnant mother above 38 degrees C or more than 101 degrees F, and may be indicative of an infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaternal Fever

Professional guidelines

PubMed

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management.
Patel S, Ciechanowicz S, Blumenfeld YJ, Sultan P
Am J Obstet Gynecol 2023 May;228(5S):S1283-S1304.e1. Epub 2023 Mar 14 doi: 10.1016/j.ajog.2022.06.026. PMID: 36925412
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article

Recent clinical studies

Etiology

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Maternal-neonatal listeriosis.
Charlier C, Disson O, Lecuit M
Virulence 2020 Dec;11(1):391-397. doi: 10.1080/21505594.2020.1759287. PMID: 32363991Free PMC Article
Challenging the "Culture" of the Tracheal Aspirate.
Claassen CC, Keenan WJ
Neoreviews 2019 Mar;20(3):e145-e151. doi: 10.1542/neo.20-3-e145. PMID: 31261052
Early Onset Sepsis.
Johnson K, Messier S
S D Med 2016 Jan;69(1):29-33. PMID: 26882580
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article

Diagnosis

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Intrauterine inflammation, infection, or both (Triple I): A new concept for chorioamnionitis.
Peng CC, Chang JH, Lin HY, Cheng PJ, Su BH
Pediatr Neonatol 2018 Jun;59(3):231-237. Epub 2017 Sep 19 doi: 10.1016/j.pedneo.2017.09.001. PMID: 29066072
Early Onset Sepsis.
Johnson K, Messier S
S D Med 2016 Jan;69(1):29-33. PMID: 26882580
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article
Neonatal listeriosis.
Ahlfors CE, Goetzman BW, Halsted CC, Sherman MP, Wennberg RP
Am J Dis Child 1977 Apr;131(4):405-8. doi: 10.1001/archpedi.1977.02120170031005. PMID: 322474

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management.
Patel S, Ciechanowicz S, Blumenfeld YJ, Sultan P
Am J Obstet Gynecol 2023 May;228(5S):S1283-S1304.e1. Epub 2023 Mar 14 doi: 10.1016/j.ajog.2022.06.026. PMID: 36925412
Epidural fever.
Hlinecká Kristýna, Bartošová Tereza, Bláha Jan
Ceska Gynekol 2021;86(5):355-361. doi: 10.48095/cccg2021355. PMID: 34736336
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms.
Sultan P, David AL, Fernando R, Ackland GL
Anesth Analg 2016 May;122(5):1546-53. doi: 10.1213/ANE.0000000000001195. PMID: 27101499
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article

Prognosis

Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes.
Abu Shqara R, Glikman D, Jad S, Rechnitzer H, Lowenstein L, Frank Wolf M
Am J Obstet Gynecol 2023 Nov;229(5):540.e1-540.e9. Epub 2023 Jul 4 doi: 10.1016/j.ajog.2023.05.013. PMID: 38051599
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management.
Patel S, Ciechanowicz S, Blumenfeld YJ, Sultan P
Am J Obstet Gynecol 2023 May;228(5S):S1283-S1304.e1. Epub 2023 Mar 14 doi: 10.1016/j.ajog.2022.06.026. PMID: 36925412
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms.
Sultan P, David AL, Fernando R, Ackland GL
Anesth Analg 2016 May;122(5):1546-53. doi: 10.1213/ANE.0000000000001195. PMID: 27101499
Early Onset Sepsis.
Johnson K, Messier S
S D Med 2016 Jan;69(1):29-33. PMID: 26882580

Clinical prediction guides

Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes.
Abu Shqara R, Glikman D, Jad S, Rechnitzer H, Lowenstein L, Frank Wolf M
Am J Obstet Gynecol 2023 Nov;229(5):540.e1-540.e9. Epub 2023 Jul 4 doi: 10.1016/j.ajog.2023.05.013. PMID: 38051599
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Risk factors of maternal intrapartum fever and the effect of fever duration on neonatal morbidity in different temperature.
Yin H, Hu R
J Obstet Gynaecol Res 2022 Oct;48(10):2522-2527. Epub 2022 Jul 12 doi: 10.1111/jog.15362. PMID: 35820774
Epidural Labor Analgesia and Maternal Fever.
Sharpe EE, Arendt KW
Clin Obstet Gynecol 2017 Jun;60(2):365-374. doi: 10.1097/GRF.0000000000000270. PMID: 28079555
Labor epidural analgesia and maternal fever.
Segal S
Anesth Analg 2010 Dec;111(6):1467-75. Epub 2010 Sep 22 doi: 10.1213/ANE.0b013e3181f713d4. PMID: 20861420

Recent systematic reviews

Factors associated with epidural-related maternal fever in low-risk term women: a systematic review.
Chang XY, Wang LZ, Xia F, Zhang YF
Int J Obstet Anesth 2023 Nov;56:103915. Epub 2023 Aug 3 doi: 10.1016/j.ijoa.2023.103915. PMID: 37625990
Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis.
Cartledge A, Hind D, Bradburn M, Martyn-St James M, Davenport S, Tung WS, Yung H, Wong J, Wilson M
Br J Anaesth 2022 Oct;129(4):567-580. Epub 2022 Aug 5 doi: 10.1016/j.bja.2022.06.022. PMID: 35934529Free PMC Article
Epidural-Related Fever and Maternal and Neonatal Morbidity: A Systematic Review and Meta-Analysis.
Jansen S, Lopriore E, Naaktgeboren C, Sueters M, Limpens J, van Leeuwen E, Bekker V
Neonatology 2020;117(3):259-270. Epub 2020 Jan 28 doi: 10.1159/000504805. PMID: 31991422
Congenital heart defects and maternal fever: systematic review and meta-analysis.
Shi QY, Zhang JB, Mi YQ, Song Y, Ma J, Zhang YL
J Perinatol 2014 Sep;34(9):677-82. Epub 2014 May 8 doi: 10.1038/jp.2014.76. PMID: 24811224
Systematic review and meta-analyses: fever in pregnancy and health impacts in the offspring.
Dreier JW, Andersen AM, Berg-Beckhoff G
Pediatrics 2014 Mar;133(3):e674-88. Epub 2014 Feb 24 doi: 10.1542/peds.2013-3205. PMID: 24567014

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