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Leukocytoclastic vasculitis

MedGen UID:
445500
•Concept ID:
C2973529
•
Disease or Syndrome
Synonyms: Hypersensitivity Vasculitis; Leukocytoclastic Vasculitis
 
HPO: HP:0034786

Definition

A type of vasculitis characterized by the presence of debris of neutrophils within the blood vessel walls. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukocytoclastic vasculitis

Professional guidelines

PubMed

Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis.
Marzano AV, Maronese CA, Genovese G, Ferrucci S, Moltrasio C, Asero R, Cugno M
J Allergy Clin Immunol 2022 Apr;149(4):1137-1149. doi: 10.1016/j.jaci.2022.02.007. PMID: 35396080
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article
Treatment of urticarial vasculitis: A systematic review.
Kolkhir P, Grakhova M, Bonnekoh H, Krause K, Maurer M
J Allergy Clin Immunol 2019 Feb;143(2):458-466. Epub 2018 Sep 27 doi: 10.1016/j.jaci.2018.09.007. PMID: 30268388

Recent clinical studies

Etiology

Skin Manifestations of VEXAS Syndrome and Associated Genotypes.
Tan IJ, Ferrada MA, Ahmad S, Fike A, Quinn KA, Groarke EM, Beck DB, Allbritton J, Castelo-Soccio L, Young NS, Patel BA, Grayson PC, Cowen EW
JAMA Dermatol 2024 Aug 1;160(8):822-829. doi: 10.1001/jamadermatol.2024.1657. PMID: 38865133Free PMC Article
Neutrophilic dermatoses.
Delaleu J, Lepelletier C, Calugareanu A, De Masson A, Charvet E, Petit A, Giurgea I, Amselem S, Karabina S, Jachiet M, Mahevas T, Ram-Wolff C, Vignon-Pennamen MD, Bagot M, Battistella M, Bouaziz JD
Rev Med Interne 2022 Dec;43(12):727-738. Epub 2022 Jul 20 doi: 10.1016/j.revmed.2022.06.007. PMID: 35870984
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
Drug-induced vasculitis.
Cuellar ML
Curr Rheumatol Rep 2002 Feb;4(1):55-9. doi: 10.1007/s11926-002-0024-y. PMID: 11798983

Diagnosis

Urticarial Vasculitis.
Wang RX, Newman SA
Immunol Allergy Clin North Am 2024 Aug;44(3):483-502. Epub 2024 May 19 doi: 10.1016/j.iac.2024.03.006. PMID: 38937011
Cutaneous Small Vessel Vasculitis: A Practical Guide to Diagnosis and Management.
Micheletti RG
Am J Clin Dermatol 2023 Jan;24(1):89-95. Epub 2022 Oct 29 doi: 10.1007/s40257-022-00736-6. PMID: 36308673
Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis.
Marzano AV, Maronese CA, Genovese G, Ferrucci S, Moltrasio C, Asero R, Cugno M
J Allergy Clin Immunol 2022 Apr;149(4):1137-1149. doi: 10.1016/j.jaci.2022.02.007. PMID: 35396080
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article
Apixaban-Induced Leukocytoclastic Vasculitis.
Liedke C, Nomani H, Lozeau D, Yao Q
J Clin Rheumatol 2021 Aug 1;27(5):e172-e173. doi: 10.1097/RHU.0000000000001310. PMID: 32040058

Therapy

Urticarial Vasculitis.
Wang RX, Newman SA
Immunol Allergy Clin North Am 2024 Aug;44(3):483-502. Epub 2024 May 19 doi: 10.1016/j.iac.2024.03.006. PMID: 38937011
Apixaban-Induced Leukocytoclastic Vasculitis.
Liedke C, Nomani H, Lozeau D, Yao Q
J Clin Rheumatol 2021 Aug 1;27(5):e172-e173. doi: 10.1097/RHU.0000000000001310. PMID: 32040058
Colon-Limited Leukocytoclastic Vasculitis.
Silva JC, Silva AP, Furtado A, Lage G, Ponte A, Pinho R, Carvalho J
Am J Gastroenterol 2018 Aug;113(8):1114. doi: 10.1038/s41395-018-0081-0. PMID: 30089809
Drug-induced cutaneous vasculitides.
Antiga E, Verdelli A, Bonciani D, Bonciolini V, Quintarelli L, Volpi W, Fabbri P, Caproni M
G Ital Dermatol Venereol 2015 Apr;150(2):203-10. Epub 2015 Mar 17 PMID: 25776141
Cutaneous small-vessel vasculitis.
Lotti T, Ghersetich I, Comacchi C, Jorizzo JL
J Am Acad Dermatol 1998 Nov;39(5 Pt 1):667-87; quiz 688-90. doi: 10.1016/s0190-9622(98)70039-8. PMID: 9810883

Prognosis

Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article
Henoch-Schönlein Purpura (IgA Vasculitis): Rapid Evidence Review.
Reamy BV, Servey JT, Williams PM
Am Fam Physician 2020 Aug 15;102(4):229-233. PMID: 32803924
Vasculitis-What Do We Have to Know? A Review of Literature.
Shavit E, Alavi A, Sibbald RG
Int J Low Extrem Wounds 2018 Dec;17(4):218-226. Epub 2018 Dec 3 doi: 10.1177/1534734618804982. PMID: 30501545
Autoinflammatory Disease-Associated Vasculitis/Vasculopathy.
Alghamdi M
Curr Rheumatol Rep 2018 Nov 17;20(12):87. doi: 10.1007/s11926-018-0788-3. PMID: 30446874

Clinical prediction guides

Skin Manifestations of VEXAS Syndrome and Associated Genotypes.
Tan IJ, Ferrada MA, Ahmad S, Fike A, Quinn KA, Groarke EM, Beck DB, Allbritton J, Castelo-Soccio L, Young NS, Patel BA, Grayson PC, Cowen EW
JAMA Dermatol 2024 Aug 1;160(8):822-829. doi: 10.1001/jamadermatol.2024.1657. PMID: 38865133Free PMC Article
Cutaneous and Mucosal Conditions Associated With Cocaine Use.
Sánchez-Puigdollers A, Just-Sarobé M, Pastor-Jané L
Actas Dermosifiliogr 2023 Feb;114(2):125-131. Epub 2022 Sep 14 doi: 10.1016/j.ad.2022.09.005. PMID: 36115385
Ceftriaxone-induced leukocytoclastic vasculitis: a case report and literature review of antibiotic-induced leukocytoclastic vasculitis.
Almasoudi AA, Bablghaith ES, Alaauldeen SI, M Falemban A, Sherbeeni AA, Bulkhi AA
J Int Med Res 2022 May;50(5):3000605221097768. doi: 10.1177/03000605221097768. PMID: 35587703Free PMC Article
Exercise-induced vasculitis.
Ramelet AA
J Eur Acad Dermatol Venereol 2006 Apr;20(4):423-7. doi: 10.1111/j.1468-3083.2006.01504.x. PMID: 16643140
Vasculitis.
Smith JG Jr
J Dermatol 1995 Nov;22(11):812-22. doi: 10.1111/j.1346-8138.1995.tb03929.x. PMID: 8557852

Recent systematic reviews

Autoimmune markers and vascular immune deposits in Finkelstein-Seidlmayer vasculitis: Systematic literature review.
Bronz G, Gianini J, Passi AG, Rizzi M, Bergmann MM, Milani GP, Lava SAG, Bianchetti MG, Terziroli Beretta-Piccoli B, Vanoni F
J Autoimmun 2023 Apr;136:103002. Epub 2023 Feb 22 doi: 10.1016/j.jaut.2023.103002. PMID: 36822150
Infections or Vaccines Associated with Finkelstein-Seidlmayer Vasculitis: Systematic Review.
Bronz G, Betti C, Rinoldi PO, Kottanattu L, Bianchetti MG, Consolascio D, Bergmann MM, Milani GP, Terziroli Beretta Piccoli B, Lava SAG
Clin Rev Allergy Immunol 2022 Dec;63(3):490-498. Epub 2022 May 12 doi: 10.1007/s12016-022-08940-2. PMID: 35553000Free PMC Article
Cutaneous effects of antihypertensive drugs.
Baccino D, Merlo G, Cozzani E, Rosa GM, Tini G, Burlando M, Parodi A
G Ital Dermatol Venereol 2020 Apr;155(2):202-211. Epub 2019 Jun 12 doi: 10.23736/S0392-0488.19.06360-0. PMID: 31195782
Treatment of urticarial vasculitis: A systematic review.
Kolkhir P, Grakhova M, Bonnekoh H, Krause K, Maurer M
J Allergy Clin Immunol 2019 Feb;143(2):458-466. Epub 2018 Sep 27 doi: 10.1016/j.jaci.2018.09.007. PMID: 30268388
Cancer risk in dermatomyositis: a systematic review of the literature.
Di Rollo D, Abeni D, Tracanna M, Capo A, Amerio P
G Ital Dermatol Venereol 2014 Oct;149(5):525-37. Epub 2014 Jun 30 PMID: 24975953

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