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Folliculosebaceous cystic hamartoma

MedGen UID:
754562
•Concept ID:
C2959380
•
Neoplastic Process
Synonym: Folliculo-sebaceous cystic hamartoma
SNOMED CT: Folliculosebaceous cystic hamartoma (446581002)

Professional guidelines

PubMed

Differential diagnostic significance of epithelial and stromal CD10 expression in tumors of trichogenic origin.
Kneitz H, Fetzer S, Goebeler M, Bröcker EB
J Dtsch Dermatol Ges 2018 Jun;16(6):719-728. doi: 10.1111/ddg.13547. PMID: 29873924
CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.
Sengul D, Sengul I, Astarci MH, Ustun H, Mocan G
Pol J Pathol 2010;61(3):140-6. PMID: 21225496

Recent clinical studies

Etiology

Hamartomas and midline anomalies in association with infantile hemangiomas, PHACE, and LUMBAR syndromes.
Stefanko NS, Davies OMT, Beato MJ, Blei F, Drolet BA, Fairley J, Frieden IJ, Galligan ER, Goddard D, Howard R, Husain S, Lauren CT, Lopez-Gutierrez JC, MacArthur C, Metry DW, Morel KD, Niedt GW, Garzon MC, Sokumbi O, Siegel DH
Pediatr Dermatol 2020 Jan;37(1):78-85. Epub 2019 Oct 20 doi: 10.1111/pde.14006. PMID: 31631401
Nasal folliculosebaceous hamartoma with vascular-mesenchymal overgrowth in an infant.
Selçuk ÖT, Osma U, Süren D, Eyigör H, Yılmaz D, Sezer C
J Craniomaxillofac Surg 2013 Apr;41(3):242-4. Epub 2012 Nov 3 doi: 10.1016/j.jcms.2012.09.008. PMID: 23127544
Folliculosebaceous cystic hamartoma of the upper lip and labial mucosa.
Islam MN, Cohen DM, Bhattacharyya I
Quintessence Int 2011 Jun;42(6):e75-7. PMID: 21519579
A revaluation of folliculosebaceous cystic hamartoma: the histopathological and immunohistochemical features.
Misago N, Kimura T, Toda S, Mori T, Narisawa Y
Am J Dermatopathol 2010 Apr;32(2):154-61. doi: 10.1097/DAD.0b013e3181a9de8c. PMID: 19755908
Folliculosebaceous cystic hamartoma or trichofolliculoma? A spectrum of hamartomatous changes inducted by perifollicular stroma in the follicular epithelium.
Wu YH
J Cutan Pathol 2008 Sep;35(9):843-8. Epub 2008 May 20 doi: 10.1111/j.1600-0560.2007.00914.x. PMID: 18494824

Diagnosis

Giant Folliculosebaceous Cystic Hamartoma.
Zhong S, Lu H
J Cutan Med Surg 2023 Nov;27(6):672. Epub 2023 Sep 19 doi: 10.1177/12034754231199748. PMID: 37724915
Acquired smooth muscle hamartoma with sebaceous component.
Marín-Hernández E, Ramírez-Rico A
Bol Med Hosp Infant Mex 2022;79(5):326-333. doi: 10.24875/BMHIM.21000177. PMID: 36264918
Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi.
Ishihara Y, Ogita A, Ito K, Saeki H, Ansai SI
Am J Dermatopathol 2022 Nov 1;44(11):817-821. Epub 2022 Sep 1 doi: 10.1097/DAD.0000000000002290. PMID: 36066121
An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands.
Shamloul G, Khachemoune A
Dermatol Ther 2021 Jan;34(1):e14695. Epub 2021 Jan 1 doi: 10.1111/dth.14695. PMID: 33354858
Folliculosebaceous cystic hamartoma of the upper lip and labial mucosa.
Islam MN, Cohen DM, Bhattacharyya I
Quintessence Int 2011 Jun;42(6):e75-7. PMID: 21519579

Therapy

Chronological changes in trichofolliculoma: Folliculosebaceous cystic hamartoma is not a very-late-stage trichofolliculoma.
Misago N, Ansai SI, Fukumoto T, Anan T, Kimura T, Nakao T
J Dermatol 2017 Sep;44(9):1050-1054. Epub 2017 Mar 31 doi: 10.1111/1346-8138.13842. PMID: 28370423

Prognosis

Neuro-folliculo-sebaceous cystic hamartoma is a unique entity.
Samaka RM, Alrahabi N
Pol J Pathol 2015 Mar;66(1):77-9. doi: 10.5114/pjp.2015.51157. PMID: 26017884
Nasal folliculosebaceous hamartoma with vascular-mesenchymal overgrowth in an infant.
Selçuk ÖT, Osma U, Süren D, Eyigör H, Yılmaz D, Sezer C
J Craniomaxillofac Surg 2013 Apr;41(3):242-4. Epub 2012 Nov 3 doi: 10.1016/j.jcms.2012.09.008. PMID: 23127544
Folliculosebaceous cystic hamartoma of the upper lip and labial mucosa.
Islam MN, Cohen DM, Bhattacharyya I
Quintessence Int 2011 Jun;42(6):e75-7. PMID: 21519579

Clinical prediction guides

Acquired smooth muscle hamartoma with sebaceous component.
Marín-Hernández E, Ramírez-Rico A
Bol Med Hosp Infant Mex 2022;79(5):326-333. doi: 10.24875/BMHIM.21000177. PMID: 36264918
Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi.
Ishihara Y, Ogita A, Ito K, Saeki H, Ansai SI
Am J Dermatopathol 2022 Nov 1;44(11):817-821. Epub 2022 Sep 1 doi: 10.1097/DAD.0000000000002290. PMID: 36066121
Solitary asymptomatic lobular perianal nodule on an infant.
Omorodion I, Lee J, Gru AA, Zlotoff BJ
Dermatol Online J 2021 Oct 15;27(10) doi: 10.5070/D3271055628. PMID: 35130389
Chronological changes in trichofolliculoma: Folliculosebaceous cystic hamartoma is not a very-late-stage trichofolliculoma.
Misago N, Ansai SI, Fukumoto T, Anan T, Kimura T, Nakao T
J Dermatol 2017 Sep;44(9):1050-1054. Epub 2017 Mar 31 doi: 10.1111/1346-8138.13842. PMID: 28370423
Genital variant of folliculosebaceous cystic hamartoma.
Bolognia JL, Longley BJ
Dermatology 1998;197(3):258-60. doi: 10.1159/000018008. PMID: 9812032

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