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Pseudoangiomatous stromal hyperplasia

MedGen UID:
418966
•Concept ID:
C2931031
•
Disease or Syndrome
Synonyms: Mammary pseudoangiomatous stromal hyperplasia; Pseudoangiomatous stromal hyperplasia of the breast
SNOMED CT: Pseudoangiomatous stromal hyperplasia (705153001)

Definition

A benign proliferation of the stromal cells in the breast. It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present. It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions. Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudoangiomatous stromal hyperplasia

Professional guidelines

PubMed

Diagnosis and treatment of a large pseudoangiomatous stromal hyperplasia.
Park JC, Jung M, Choi J
Asian J Surg 2023 Dec;46(12):5835-5837. Epub 2023 Aug 31 doi: 10.1016/j.asjsur.2023.08.177. PMID: 37659942
Management of Gynecomastia and Male Benign Diseases.
Karamchandani MM, De La Cruz Ku G, Sokol BL, Chatterjee A, Homsy C
Surg Clin North Am 2022 Dec;102(6):989-1005. doi: 10.1016/j.suc.2022.06.003. PMID: 36335933
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Treatment of Pseudoangiomatous Stromal Hyperplasia of the Breast: Literature Review and Successful Management of a Teenage Girl by Breast Reduction With 10-Year Follow-up.
Yturralde KJ, Friedman HI
Ann Plast Surg 2023 Jul 1;91(1):194-197. doi: 10.1097/SAP.0000000000003593. PMID: 37450878
Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Pseudoangiomatous Stromal Hyperplasia of the Breast: Multimodality Review With Pathologic Correlation.
Raj SD, Sahani VG, Adrada BE, Scoggins ME, Albarracin CT, Woodtichartpreecha P, Posleman Monetto FE, Whitman GJ
Curr Probl Diagn Radiol 2017 Mar-Apr;46(2):130-135. Epub 2016 Feb 2 doi: 10.1067/j.cpradiol.2016.01.005. PMID: 26949063
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Diagnosis

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Mesenchymal breast lesions.
Schickman R, Leibman AJ, Handa P, Kornmehl A, Abadi M
Clin Radiol 2015 Jun;70(6):567-75. Epub 2015 Jan 29 doi: 10.1016/j.crad.2014.12.015. PMID: 25638601
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Therapy

A review of pediatric macromastia etiology and indications for reduction mammaplasty.
Kikuchi DS, Mustin DE, Ghanouni A, Walsh MD
J Plast Reconstr Aesthet Surg 2023 Feb;77:209-217. Epub 2022 Dec 19 doi: 10.1016/j.bjps.2022.12.003. PMID: 36587475
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Breast hamartoma: reassessment of an under-recognised breast lesion.
Alran L, Chamming's F, Auriol-Leizagoyen S, Velasco V, Deleau F, Brouste V, Bonhomme B, Ben Rejeb H, Marty M, MacGrogan G
Histopathology 2022 Jan;80(2):304-313. Epub 2021 Sep 22 doi: 10.1111/his.14544. PMID: 34403159
Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature.
Canu GL, Medas F, Ravarino A, Furcas S, Loi G, Cerrone G, Rossi C, Erdas E, Calò P G
G Chir 2018 Nov-Dec;39(6):378-382. PMID: 30563602
Pseudoangiomatous stromal hyperplasia of the breast.
AbdullGaffar B
Arch Pathol Lab Med 2009 Aug;133(8):1335-8. doi: 10.5858/133.8.1335. PMID: 19653734

Prognosis

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640
Pseudoangiomatous stromal hyperplasia of the breast.
AbdullGaffar B
Arch Pathol Lab Med 2009 Aug;133(8):1335-8. doi: 10.5858/133.8.1335. PMID: 19653734

Clinical prediction guides

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Treatment of Pseudoangiomatous Stromal Hyperplasia of the Breast: Literature Review and Successful Management of a Teenage Girl by Breast Reduction With 10-Year Follow-up.
Yturralde KJ, Friedman HI
Ann Plast Surg 2023 Jul 1;91(1):194-197. doi: 10.1097/SAP.0000000000003593. PMID: 37450878
Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104

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