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Optic Disc Edema

MedGen UID:
419265
•Concept ID:
C2930835
•
Disease or Syndrome

Definition

Swelling of the optic disc in the absence of increased intracranial pressure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOptic Disc Edema

Professional guidelines

PubMed

Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema.
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Dysthyroid optic neuropathy: evaluation and management.
Dolman PJ
J Endocrinol Invest 2021 Mar;44(3):421-429. Epub 2020 Jul 29 doi: 10.1007/s40618-020-01361-y. PMID: 32729049
ACR Appropriateness Criteria® Headache.
Expert Panel on Neurologic Imaging, Whitehead MT, Cardenas AM, Corey AS, Policeni B, Burns J, Chakraborty S, Crowley RW, Jabbour P, Ledbetter LN, Lee RK, Pannell JS, Pollock JM, Powers WJ, Setzen G, Shih RY, Subramaniam RM, Utukuri PS, Bykowski J
J Am Coll Radiol 2019 Nov;16(11S):S364-S377. doi: 10.1016/j.jacr.2019.05.030. PMID: 31685104

Recent clinical studies

Etiology

Papillitis associated with IgLON5 autoimmunity: A novel clinical phenotype.
Li X, Chen JJ, Hur M, Paton GR, McKeon A, Zekeridou A
J Neuroimmunol 2024 Mar 15;388:578312. Epub 2024 Feb 5 doi: 10.1016/j.jneuroim.2024.578312. PMID: 38364528Free PMC Article
Beyond Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies: Alternative Causes of Optic Neuritis.
Greco G, Colombo E, Gastaldi M, Ahmad L, Tavazzi E, Bergamaschi R, Rigoni E
Int J Mol Sci 2023 Nov 5;24(21) doi: 10.3390/ijms242115986. PMID: 37958968Free PMC Article
Brain Physiological Response and Adaptation During Spaceflight.
Marshall-Goebel K, Damani R, Bershad EM
Neurosurgery 2019 Nov 1;85(5):E815-E821. doi: 10.1093/neuros/nyz203. PMID: 31215633
Pediatric Uveitis.
Chan NS, Choi J, Cheung CMG
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):192-199. Epub 2018 Apr 23 doi: 10.22608/APO.2018116. PMID: 29682916
Ocular manifestations of leptospirosis.
Rathinam SR
J Postgrad Med 2005 Jul-Sep;51(3):189-94. PMID: 16333191

Diagnosis

Not everything is ischemic optic neuropathy.
Hernández RF, Rodriguez JEM, Trecu MS, Bhatti MT
Surv Ophthalmol 2024 Nov-Dec;69(6):984-989. Epub 2024 May 23 doi: 10.1016/j.survophthal.2024.05.005. PMID: 38796109
A high-pressure situation.
Miller MJ, Hicks MJ, Foroozan R, Brodsky MC
Surv Ophthalmol 2023 Jul-Aug;68(4):815-820. Epub 2022 Aug 12 doi: 10.1016/j.survophthal.2022.08.001. PMID: 35970231
Occam versus Hickam.
Cobbs L, Murchison AP, DeBusk A, Bilyk JR
Surv Ophthalmol 2022 Nov-Dec;67(6):1717-1722. Epub 2022 Jun 17 doi: 10.1016/j.survophthal.2022.06.001. PMID: 35718026
Brain Physiological Response and Adaptation During Spaceflight.
Marshall-Goebel K, Damani R, Bershad EM
Neurosurgery 2019 Nov 1;85(5):E815-E821. doi: 10.1093/neuros/nyz203. PMID: 31215633
Big red flags in neuro-ophthalmology.
Ling JD, Chao D, Al Zubidi N, Lee AG
Can J Ophthalmol 2013 Feb;48(1):3-7. doi: 10.1016/j.jcjo.2012.08.016. PMID: 23419292

Therapy

Papillitis associated with IgLON5 autoimmunity: A novel clinical phenotype.
Li X, Chen JJ, Hur M, Paton GR, McKeon A, Zekeridou A
J Neuroimmunol 2024 Mar 15;388:578312. Epub 2024 Feb 5 doi: 10.1016/j.jneuroim.2024.578312. PMID: 38364528Free PMC Article
A high-pressure situation.
Miller MJ, Hicks MJ, Foroozan R, Brodsky MC
Surv Ophthalmol 2023 Jul-Aug;68(4):815-820. Epub 2022 Aug 12 doi: 10.1016/j.survophthal.2022.08.001. PMID: 35970231
BILATERAL PARACENTRAL ACUTE MIDDLE MACULOPATHY AFTER CARDIOPULMONARY BYPASS.
Michalak SM, Mukherjee N, Gospe SM 3rd
Retin Cases Brief Rep 2022 May 1;16(3):285-288. Epub 2020 Feb 6 doi: 10.1097/ICB.0000000000000982. PMID: 32032289
Tuberculous neuroretinitis.
Stechschulte SU, Kim RY, Cunningham ET Jr
J Neuroophthalmol 1999 Sep;19(3):201-4. PMID: 10494950
Cryptococcal choroiditis.
Carney MD, Combs JL, Waschler W
Retina 1990;10(1):27-32. PMID: 2343188

Prognosis

An update on optic neuritis.
Kraker JA, Chen JJ
J Neurol 2023 Oct;270(10):5113-5126. Epub 2023 Aug 5 doi: 10.1007/s00415-023-11920-x. PMID: 37542657
A high-pressure situation.
Miller MJ, Hicks MJ, Foroozan R, Brodsky MC
Surv Ophthalmol 2023 Jul-Aug;68(4):815-820. Epub 2022 Aug 12 doi: 10.1016/j.survophthal.2022.08.001. PMID: 35970231
Occam versus Hickam.
Cobbs L, Murchison AP, DeBusk A, Bilyk JR
Surv Ophthalmol 2022 Nov-Dec;67(6):1717-1722. Epub 2022 Jun 17 doi: 10.1016/j.survophthal.2022.06.001. PMID: 35718026
Neuroretinitis: a review.
Abdelhakim A, Rasool N
Curr Opin Ophthalmol 2018 Nov;29(6):514-519. doi: 10.1097/ICU.0000000000000527. PMID: 30148725
Ocular manifestations of leptospirosis.
Rathinam SR
J Postgrad Med 2005 Jul-Sep;51(3):189-94. PMID: 16333191

Clinical prediction guides

BILATERAL PARACENTRAL ACUTE MIDDLE MACULOPATHY AFTER CARDIOPULMONARY BYPASS.
Michalak SM, Mukherjee N, Gospe SM 3rd
Retin Cases Brief Rep 2022 May 1;16(3):285-288. Epub 2020 Feb 6 doi: 10.1097/ICB.0000000000000982. PMID: 32032289
Calciphylaxis and bilateral optic neuropathy.
Huerva V, Sánchez MC, Ascaso FJ, Craver L, Fernández E
J Fr Ophtalmol 2011 Nov;34(9):651.e1-4. Epub 2011 Jun 15 doi: 10.1016/j.jfo.2011.02.010. PMID: 21680055
Ocular manifestations of leptospirosis.
Rathinam SR
J Postgrad Med 2005 Jul-Sep;51(3):189-94. PMID: 16333191
Brucella meningitis and papilledema in a child.
Levy J, Shneck M, Marcus M, Lifshitz T
Eur J Ophthalmol 2005 Nov-Dec;15(6):818-20. doi: 10.1177/112067210501500628. PMID: 16329074
Ocular vaso-occlusive disease in primary antiphospholipid syndrome.
Castañón C, Amigo MC, Bañales JL, Nava A, Reyes PA
Ophthalmology 1995 Feb;102(2):256-62. doi: 10.1016/s0161-6420(95)31028-7. PMID: 7862414

Recent systematic reviews

Visual System Involvement in Glial Fibrillary Acidic Protein Astrocytopathy: Two Case Reports and a Systematic Literature Review.
Greco G, Masciocchi S, Diamanti L, Bini P, Vegezzi E, Marchioni E, Colombo E, Rigoni E, Businaro P, Ferraro OE, Bianchi Marzoli S, Bergamaschi R, Franciotta D, Gastaldi M
Neurol Neuroimmunol Neuroinflamm 2023 Sep;10(5) Epub 2023 Aug 15 doi: 10.1212/NXI.0000000000200146. PMID: 37582612Free PMC Article
Inappropriate Indexing of Case Reports to the "Papilledema" Subject Heading: A Systematic Review.
Tao BK, Vosoughi AR, Pandya BU, Ishaq J, Margolin EA, Micieli JA
J Neuroophthalmol 2023 Dec 1;43(4):525-530. Epub 2023 Jun 12 doi: 10.1097/WNO.0000000000001895. PMID: 37307081
Inappropriate Use of the Term "Papilledema" in the Medical Literature: A Systematic Review of Case Reports across Specialties.
Tao B, Vosoughi A, Margolin E, Micieli JA
Ophthalmology 2023 Feb;130(2):129-136. Epub 2022 Oct 3 doi: 10.1016/j.ophtha.2022.09.017. PMID: 36195254
Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review.
Lotan I, Lydston M, Levy M
J Neuroophthalmol 2022 Jun 1;42(2):154-162. Epub 2022 Mar 25 doi: 10.1097/WNO.0000000000001537. PMID: 35427282
Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review.
Song JH, Koreishi AF, Goldstein DA
Ocul Immunol Inflamm 2019;27(6):998-1009. Epub 2018 Jul 3 doi: 10.1080/09273948.2018.1485958. PMID: 29969330

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