U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sepsis caused by Streptococcus pneumoniae

MedGen UID:
753428
•Concept ID:
C2887084
•
Disease or Syndrome
Synonym: Severe sepsis with acute organ dysfunction caused by Pneumococcus
SNOMED CT: Sepsis caused by Streptococcus pneumoniae (448421008); Severe sepsis with acute organ dysfunction caused by Pneumococcus (448421008)

Professional guidelines

PubMed

Tailored liposomal nanotraps for the treatment of Streptococcal infections.
Besançon H, Babiychuk V, Larpin Y, Köffel R, Schittny D, Brockhus L, Hathaway LJ, Sendi P, Draeger A, Babiychuk E
J Nanobiotechnology 2021 Feb 15;19(1):46. doi: 10.1186/s12951-021-00775-x. PMID: 33588835Free PMC Article
Management of fever without source in infants and children.
Baraff LJ
Ann Emerg Med 2000 Dec;36(6):602-14. doi: 10.1067/mem.2000.110820. PMID: 11097701
Management of infections caused by antibiotic-resistant Streptococcus pneumoniae.
Friedland IR, McCracken GH Jr
N Engl J Med 1994 Aug 11;331(6):377-82. doi: 10.1056/NEJM199408113310607. PMID: 8028618

Recent clinical studies

Etiology

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Antimicrobial Resistance Collaborators
Lancet 2022 Dec 17;400(10369):2221-2248. Epub 2022 Nov 21 doi: 10.1016/S0140-6736(22)02185-7. PMID: 36423648Free PMC Article
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Influenza virus-related critical illness: pathophysiology and epidemiology.
Kalil AC, Thomas PG
Crit Care 2019 Jul 19;23(1):258. doi: 10.1186/s13054-019-2539-x. PMID: 31324202Free PMC Article
Prevalence, Risk Factors, and Outcomes of Bacteremic Pneumonia in Children.
Fritz CQ, Edwards KM, Self WH, Grijalva CG, Zhu Y, Arnold SR, McCullers JA, Ampofo K, Pavia AT, Wunderink RG, Anderson EJ, Bramley AM, Jain S, Williams DJ
Pediatrics 2019 Jul;144(1) doi: 10.1542/peds.2018-3090. PMID: 31217309Free PMC Article
Pneumococcal vaccines.
Manoharan A, Jayaraman R
Indian J Med Microbiol 2018 Oct-Dec;36(4):465-474. doi: 10.4103/ijmm.IJMM_18_442. PMID: 30880692

Diagnosis

Fatal Pediatric Streptococcal Infection: A Clinico-Pathological Study.
Nagy A, Reyes JA, Chiasson DA
Pediatr Dev Pathol 2022 Jul-Aug;25(4):409-418. Epub 2022 Feb 28 doi: 10.1177/10935266211064696. PMID: 35227107Free PMC Article
Influenza virus-related critical illness: pathophysiology and epidemiology.
Kalil AC, Thomas PG
Crit Care 2019 Jul 19;23(1):258. doi: 10.1186/s13054-019-2539-x. PMID: 31324202Free PMC Article
Prevalence, Risk Factors, and Outcomes of Bacteremic Pneumonia in Children.
Fritz CQ, Edwards KM, Self WH, Grijalva CG, Zhu Y, Arnold SR, McCullers JA, Ampofo K, Pavia AT, Wunderink RG, Anderson EJ, Bramley AM, Jain S, Williams DJ
Pediatrics 2019 Jul;144(1) doi: 10.1542/peds.2018-3090. PMID: 31217309Free PMC Article
Heartfelt sepsis: microvascular injury due to genomic storm.
Hawiger J
Kardiol Pol 2018;76(8):1203-1216. Epub 2018 Jul 5 doi: 10.5603/KP.a2018.0146. PMID: 29974447
Pneumococcal infections.
Maraqa NF
Pediatr Rev 2014 Jul;35(7):299-310. doi: 10.1542/pir.35-7-299. PMID: 24986929

Therapy

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Pneumococcal Vaccines.
Briles DE, Paton JC, Mukerji R, Swiatlo E, Crain MJ
Microbiol Spectr 2019 Nov;7(6) doi: 10.1128/microbiolspec.GPP3-0028-2018. PMID: 31858954Free PMC Article
Influenza virus-related critical illness: pathophysiology and epidemiology.
Kalil AC, Thomas PG
Crit Care 2019 Jul 19;23(1):258. doi: 10.1186/s13054-019-2539-x. PMID: 31324202Free PMC Article
Pneumococcal vaccines.
Manoharan A, Jayaraman R
Indian J Med Microbiol 2018 Oct-Dec;36(4):465-474. doi: 10.4103/ijmm.IJMM_18_442. PMID: 30880692
Pneumococcal infections.
Maraqa NF
Pediatr Rev 2014 Jul;35(7):299-310. doi: 10.1542/pir.35-7-299. PMID: 24986929

Prognosis

Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium.
Shaw D, Abad R, Amin-Chowdhury Z, Bautista A, Bennett D, Broughton K, Cao B, Casanova C, Choi EH, Chu YW, Claus H, Coelho J, Corcoran M, Cottrell S, Cunney R, Cuypers L, Dalby T, Davies H, de Gouveia L, Deghmane AE, Demczuk W, Desmet S, Domenech M, Drew R, du Plessis M, Duarte C, Erlendsdóttir H, Fry NK, Fuursted K, Hale T, Henares D, Henriques-Normark B, Hilty M, Hoffmann S, Humphreys H, Ip M, Jacobsson S, Johnson C, Johnston J, Jolley KA, Kawabata A, Kozakova J, Kristinsson KG, Krizova P, Kuch A, Ladhani S, Lâm TT, León ME, Lindholm L, Litt D, Maiden MCJ, Martin I, Martiny D, Mattheus W, McCarthy ND, Meehan M, Meiring S, Mölling P, Morfeldt E, Morgan J, Mulhall R, Muñoz-Almagro C, Murdoch D, Murphy J, Musilek M, Mzabi A, Novakova L, Oftadeh S, Perez-Argüello A, Pérez-Vázquez M, Perrin M, Perry M, Prevost B, Roberts M, Rokney A, Ron M, Sanabria OM, Scott KJ, Sheppard C, Siira L, Sintchenko V, Skoczyńska A, Sloan M, Slotved HC, Smith AJ, Steens A, Taha MK, Toropainen M, Tzanakaki G, Vainio A, van der Linden MPG, van Sorge NM, Varon E, Vohrnova S, von Gottberg A, Yuste J, Zanella R, Zhou F, Brueggemann AB
Lancet Digit Health 2023 Sep;5(9):e582-e593. Epub 2023 Jul 27 doi: 10.1016/S2589-7500(23)00108-5. PMID: 37516557Free PMC Article
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Pneumococcal vaccines.
Manoharan A, Jayaraman R
Indian J Med Microbiol 2018 Oct-Dec;36(4):465-474. doi: 10.4103/ijmm.IJMM_18_442. PMID: 30880692
Pneumococcal infections.
Maraqa NF
Pediatr Rev 2014 Jul;35(7):299-310. doi: 10.1542/pir.35-7-299. PMID: 24986929
Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines.
Lynch JP 3rd, Zhanel GG
Curr Opin Pulm Med 2010 May;16(3):217-25. doi: 10.1097/MCP.0b013e3283385653. PMID: 20375783

Clinical prediction guides

Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium.
Shaw D, Abad R, Amin-Chowdhury Z, Bautista A, Bennett D, Broughton K, Cao B, Casanova C, Choi EH, Chu YW, Claus H, Coelho J, Corcoran M, Cottrell S, Cunney R, Cuypers L, Dalby T, Davies H, de Gouveia L, Deghmane AE, Demczuk W, Desmet S, Domenech M, Drew R, du Plessis M, Duarte C, Erlendsdóttir H, Fry NK, Fuursted K, Hale T, Henares D, Henriques-Normark B, Hilty M, Hoffmann S, Humphreys H, Ip M, Jacobsson S, Johnson C, Johnston J, Jolley KA, Kawabata A, Kozakova J, Kristinsson KG, Krizova P, Kuch A, Ladhani S, Lâm TT, León ME, Lindholm L, Litt D, Maiden MCJ, Martin I, Martiny D, Mattheus W, McCarthy ND, Meehan M, Meiring S, Mölling P, Morfeldt E, Morgan J, Mulhall R, Muñoz-Almagro C, Murdoch D, Murphy J, Musilek M, Mzabi A, Novakova L, Oftadeh S, Perez-Argüello A, Pérez-Vázquez M, Perrin M, Perry M, Prevost B, Roberts M, Rokney A, Ron M, Sanabria OM, Scott KJ, Sheppard C, Siira L, Sintchenko V, Skoczyńska A, Sloan M, Slotved HC, Smith AJ, Steens A, Taha MK, Toropainen M, Tzanakaki G, Vainio A, van der Linden MPG, van Sorge NM, Varon E, Vohrnova S, von Gottberg A, Yuste J, Zanella R, Zhou F, Brueggemann AB
Lancet Digit Health 2023 Sep;5(9):e582-e593. Epub 2023 Jul 27 doi: 10.1016/S2589-7500(23)00108-5. PMID: 37516557Free PMC Article
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Neutrophilic thrombophagocytosis.
Amouroux I, Lesesve JF
Morphologie 2020 Mar;104(344):73-75. Epub 2019 Sep 11 doi: 10.1016/j.morpho.2019.08.004. PMID: 31521508
Pneumococcal infections.
Maraqa NF
Pediatr Rev 2014 Jul;35(7):299-310. doi: 10.1542/pir.35-7-299. PMID: 24986929
Streptococcus pneumoniae bacteraemia in children.
Myers C, Gervaix A
Int J Antimicrob Agents 2007 Nov;30 Suppl 1:S24-8. Epub 2007 Aug 20 doi: 10.1016/j.ijantimicag.2007.06.018. PMID: 17707612

Recent systematic reviews

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Host genetic variability and pneumococcal disease: a systematic review and meta-analysis.
Kloek AT, Brouwer MC, van de Beek D
BMC Med Genomics 2019 Sep 13;12(1):130. doi: 10.1186/s12920-019-0572-x. PMID: 31519222Free PMC Article
Serotype distribution and antimicrobial susceptibility pattern in children≤5years with invasive pneumococcal disease in India - A systematic review.
Singh J, Sundaresan S, Manoharan A, Shet A
Vaccine 2017 Aug 16;35(35 Pt B):4501-4509. Epub 2017 Jul 12 doi: 10.1016/j.vaccine.2017.06.079. PMID: 28711387
Community-acquired neonatal and infant sepsis in developing countries: efficacy of WHO's currently recommended antibiotics--systematic review and meta-analysis.
Downie L, Armiento R, Subhi R, Kelly J, Clifford V, Duke T
Arch Dis Child 2013 Feb;98(2):146-54. Epub 2012 Nov 9 doi: 10.1136/archdischild-2012-302033. PMID: 23142784
Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates.
O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, McCall N, Lee E, Mulholland K, Levine OS, Cherian T; Hib and Pneumococcal Global Burden of Disease Study Team
Lancet 2009 Sep 12;374(9693):893-902. doi: 10.1016/S0140-6736(09)61204-6. PMID: 19748398

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...