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Cerebral Amyloid Angiopathy, Gsn-Related

MedGen UID:
442741
•Concept ID:
C2751493
•
Disease or Syndrome
Synonym: CEREBRAL AMYLOID ANGIOPATHY, GSN-RELATED
 
OMIM®: 105120

Professional guidelines

PubMed

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association.
Greenberg SM, Ziai WC, Cordonnier C, Dowlatshahi D, Francis B, Goldstein JN, Hemphill JC 3rd, Johnson R, Keigher KM, Mack WJ, Mocco J, Newton EJ, Ruff IM, Sansing LH, Schulman S, Selim MH, Sheth KN, Sprigg N, Sunnerhagen KS; American Heart Association/American Stroke Association
Stroke 2022 Jul;53(7):e282-e361. Epub 2022 May 17 doi: 10.1161/STR.0000000000000407. PMID: 35579034
Intracerebral hemorrhage: an update on diagnosis and treatment.
Hostettler IC, Seiffge DJ, Werring DJ
Expert Rev Neurother 2019 Jul;19(7):679-694. Epub 2019 Jun 12 doi: 10.1080/14737175.2019.1623671. PMID: 31188036

Recent clinical studies

Etiology

Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease.
Solopova E, Romero-Fernandez W, Harmsen H, Ventura-Antunes L, Wang E, Shostak A, Maldonado J, Donahue MJ, Schultz D, Coyne TM, Charidimou A, Schrag M
Nat Commun 2023 Dec 12;14(1):8220. doi: 10.1038/s41467-023-43933-5. PMID: 38086820Free PMC Article
Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment.
Cozza M, Amadori L, Boccardi V
J Neurol Sci 2023 Nov 15;454:120866. Epub 2023 Nov 2 doi: 10.1016/j.jns.2023.120866. PMID: 37931443
Cerebral Amyloid Angiopathy.
Szidonya L, Nickerson JP
Radiol Clin North Am 2023 May;61(3):551-562. Epub 2023 Feb 20 doi: 10.1016/j.rcl.2023.01.009. PMID: 36931769
Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies.
Kurz C, Walker L, Rauchmann BS, Perneczky R
Neuropathol Appl Neurobiol 2022 Apr;48(3):e12782. Epub 2022 Feb 2 doi: 10.1111/nan.12782. PMID: 34823269
A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article

Diagnosis

Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment.
Cozza M, Amadori L, Boccardi V
J Neurol Sci 2023 Nov 15;454:120866. Epub 2023 Nov 2 doi: 10.1016/j.jns.2023.120866. PMID: 37931443
Cerebral Amyloid Angiopathy.
Szidonya L, Nickerson JP
Radiol Clin North Am 2023 May;61(3):551-562. Epub 2023 Feb 20 doi: 10.1016/j.rcl.2023.01.009. PMID: 36931769
Cerebral amyloid angiopathy and related inflammatory disorders.
Chwalisz BK
J Neurol Sci 2021 May 15;424:117425. Epub 2021 Mar 27 doi: 10.1016/j.jns.2021.117425. PMID: 33840507
A practical approach to the management of cerebral amyloid angiopathy.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ
Int J Stroke 2021 Jun;16(4):356-369. Epub 2020 Nov 29 doi: 10.1177/1747493020974464. PMID: 33252026Free PMC Article
CNS small vessel disease: A clinical review.
Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF
Neurology 2019 Jun 11;92(24):1146-1156. Epub 2019 May 29 doi: 10.1212/WNL.0000000000007654. PMID: 31142635Free PMC Article

Therapy

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics.
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Cerebral small vessel disease: Recent advances and future directions.
Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578Free PMC Article
Management of Intracerebral Hemorrhage: JACC Focus Seminar.
Schrag M, Kirshner H
J Am Coll Cardiol 2020 Apr 21;75(15):1819-1831. doi: 10.1016/j.jacc.2019.10.066. PMID: 32299594
CNS small vessel disease: A clinical review.
Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF
Neurology 2019 Jun 11;92(24):1146-1156. Epub 2019 May 29 doi: 10.1212/WNL.0000000000007654. PMID: 31142635Free PMC Article
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.
Pantoni L
Lancet Neurol 2010 Jul;9(7):689-701. doi: 10.1016/S1474-4422(10)70104-6. PMID: 20610345

Prognosis

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics.
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A
Brain 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110Free PMC Article
Cerebral amyloid angiopathy-related inflammation: current status and future implications.
Wu JJ, Yao M, Ni J
Chin Med J (Engl) 2021 Feb 23;134(6):646-654. doi: 10.1097/CM9.0000000000001427. PMID: 33625036Free PMC Article
Management of Intracerebral Hemorrhage: JACC Focus Seminar.
Schrag M, Kirshner H
J Am Coll Cardiol 2020 Apr 21;75(15):1819-1831. doi: 10.1016/j.jacc.2019.10.066. PMID: 32299594
Intracerebral hemorrhage: an update on diagnosis and treatment.
Hostettler IC, Seiffge DJ, Werring DJ
Expert Rev Neurother 2019 Jul;19(7):679-694. Epub 2019 Jun 12 doi: 10.1080/14737175.2019.1623671. PMID: 31188036
Intracerebral haemorrhage.
Qureshi AI, Mendelow AD, Hanley DF
Lancet 2009 May 9;373(9675):1632-44. doi: 10.1016/S0140-6736(09)60371-8. PMID: 19427958Free PMC Article

Clinical prediction guides

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.
Markus HS, van Der Flier WM, Smith EE, Bath P, Biessels GJ, Briceno E, Brodtman A, Chabriat H, Chen C, de Leeuw FE, Egle M, Ganesh A, Georgakis MK, Gottesman RF, Kwon S, Launer L, Mok V, O'Brien J, Ottenhoff L, Pendlebury S, Richard E, Sachdev P, Schmidt R, Springer M, Tiedt S, Wardlaw JM, Verdelho A, Webb A, Werring D, Duering M, Levine D, Dichgans M
JAMA Neurol 2022 Nov 1;79(11):1187-1198. doi: 10.1001/jamaneurol.2022.2262. PMID: 35969390Free PMC Article
Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies.
Kurz C, Walker L, Rauchmann BS, Perneczky R
Neuropathol Appl Neurobiol 2022 Apr;48(3):e12782. Epub 2022 Feb 2 doi: 10.1111/nan.12782. PMID: 34823269
Prevalence of cerebral amyloid angiopathy: A systematic review and meta-analysis.
Jäkel L, De Kort AM, Klijn CJM, Schreuder FHBM, Verbeek MM
Alzheimers Dement 2022 Jan;18(1):10-28. Epub 2021 May 31 doi: 10.1002/alz.12366. PMID: 34057813Free PMC Article
Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study.
Antolini L, DiFrancesco JC, Zedde M, Basso G, Arighi A, Shima A, Cagnin A, Caulo M, Carare RO, Charidimou A, Cirillo M, Di Lazzaro V, Ferrarese C, Giossi A, Inzitari D, Marcon M, Marconi R, Ihara M, Nitrini R, Orlandi B, Padovani A, Pascarella R, Perini F, Perini G, Sessa M, Scarpini E, Tagliavini F, Valenti R, Vázquez-Costa JF, Villarejo-Galende A, Hagiwara Y, Ziliotto N, Piazza F
Neurology 2021 Nov 2;97(18):e1809-e1822. Epub 2021 Sep 16 doi: 10.1212/WNL.0000000000012778. PMID: 34531298Free PMC Article
Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina.
Shi H, Koronyo Y, Rentsendorj A, Regis GC, Sheyn J, Fuchs DT, Kramerov AA, Ljubimov AV, Dumitrascu OM, Rodriguez AR, Barron E, Hinton DR, Black KL, Miller CA, Mirzaei N, Koronyo-Hamaoui M
Acta Neuropathol 2020 May;139(5):813-836. Epub 2020 Feb 10 doi: 10.1007/s00401-020-02134-w. PMID: 32043162Free PMC Article

Recent systematic reviews

Associations between neurovascular coupling and cerebral small vessel disease: A systematic review and meta-analysis.
Yang S, Webb AJS
Eur Stroke J 2023 Dec;8(4):895-903. Epub 2023 Sep 11 doi: 10.1177/23969873231196981. PMID: 37697725Free PMC Article
Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.
Theodorou A, Palaiodimou L, Malhotra K, Zompola C, Katsanos AH, Shoamanesh A, Boviatsis E, Dardiotis E, Spilioti M, Sacco S, Werring DJ, Cordonnier C, Alexandrov AV, Paraskevas GP, Tsivgoulis G
Stroke 2023 Jan;54(1):178-188. Epub 2022 Dec 1 doi: 10.1161/STROKEAHA.122.040671. PMID: 36453271
Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies.
Kurz C, Walker L, Rauchmann BS, Perneczky R
Neuropathol Appl Neurobiol 2022 Apr;48(3):e12782. Epub 2022 Feb 2 doi: 10.1111/nan.12782. PMID: 34823269
Prevalence of cerebral amyloid angiopathy: A systematic review and meta-analysis.
Jäkel L, De Kort AM, Klijn CJM, Schreuder FHBM, Verbeek MM
Alzheimers Dement 2022 Jan;18(1):10-28. Epub 2021 May 31 doi: 10.1002/alz.12366. PMID: 34057813Free PMC Article
Imaging features of intracerebral hemorrhage with cerebral amyloid angiopathy: Systematic review and meta-analysis.
Samarasekera N, Rodrigues MA, Toh PS, Al-Shahi R
PLoS One 2017;12(7):e0180923. Epub 2017 Jul 10 doi: 10.1371/journal.pone.0180923. PMID: 28700676Free PMC Article

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