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NONPAPILLARY RENAL CARCINOMA 1 LOCUS(NRC1)

MedGen UID:
413407
•Concept ID:
C2750825
•
Finding
Synonym: NRC1
 
OMIM®: 144700

Clinical features

From HPO
Renal cell carcinoma
MedGen UID:
766
•Concept ID:
C0007134
•
Neoplastic Process
A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.
See: Feature record | Search on this feature

Recent clinical studies

Etiology

Renal-cell carcinoma in children: a different disorder from its adult counterpart?
Carcao MD, Taylor GP, Greenberg ML, Bernstein ML, Champagne M, Hershon L, Baruchel S
Med Pediatr Oncol 1998 Sep;31(3):153-8. doi: 10.1002/(sici)1096-911x(199809)31:3<153::aid-mpo5>3.0.co;2-a. PMID: 9722897

Clinical prediction guides

Novel tumor suppressor locus in human chromosome region 3p14.2.
Jülicher K, Marquitan G, Werner N, Bardenheuer W, Vieten L, Bröcker F, Topal H, Seeber S, Opalka B, Schütte J
J Natl Cancer Inst 1999 Sep 15;91(18):1563-8. doi: 10.1093/jnci/91.18.1563. PMID: 10491433
The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation.
Lovell M, Lott ST, Wong P, El-Naggar A, Tucker S, Killary AM
Cancer Res 1999 May 1;59(9):2182-9. PMID: 10232606
FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas.
Bugert P, Wilhelm M, Kovacs G
Genes Chromosomes Cancer 1997 Sep;20(1):9-15. PMID: 9290948
Duplication of an approximately 1.5 Mb DNA segment at chromosome 5q22 indicates the locus of a new tumour gene in nonpapillary renal cell carcinomas.
Kenck C, Bugert P, Wilhelm M, Kovacs G
Oncogene 1997 Mar 6;14(9):1093-8. doi: 10.1038/sj.onc.1200915. PMID: 9070658
PCR-based RFLP screening of the commonly deleted 3p loci in renal cortical neoplasms.
el-Naggar AK, Batsakis JG, Wang G, Lee MS
Diagn Mol Pathol 1993 Dec;2(4):269-76. PMID: 7906993

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