U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vitreomacular adhesion

MedGen UID:
1373201
•Concept ID:
C2748203
•
Disease or Syndrome
Synonyms: VMA; VMA - vitreomacular adhesion
SNOMED CT: VMA - vitreomacular adhesion (1119266006); Vitreomacular adhesion (1119266006)
 
HPO: HP:0031150

Definition

Perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features. It is an OCT finding that is almost always the result of normal vitreous aging, which may lead to pathologic conditions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitreomacular adhesion

Professional guidelines

PubMed

Intravitreal ocriplasmin: A breakthrough in the treatment of vitreomacular traction?
Mec-Słomska AE, Adamiec-Mroczek J, Kuźmicz E, Misiuk-Hojło M
Adv Clin Exp Med 2017 May-Jun;26(3):527-531. doi: 10.17219/acem/62122. PMID: 28791829
Vitreomacular adhesion or vitreomacular traction may affect antivascular endothelium growth factor treatment for neovascular age-related macular degeneration.
Xie P, Zheng X, Yu Y, Ye X, Hu Z, Yuan D, Liu Q
Br J Ophthalmol 2017 Aug;101(8):1003-1010. Epub 2017 Jun 8 doi: 10.1136/bjophthalmol-2017-310155. PMID: 28596285
Optical coherence tomography in the preoperative and postoperative management of macular hole and epiretinal membrane.
Goldberg RA, Waheed NK, Duker JS
Br J Ophthalmol 2014 Jul;98 Suppl 2(Suppl 2):ii20-3. Epub 2014 Mar 13 doi: 10.1136/bjophthalmol-2013-304447. PMID: 24627250Free PMC Article

Recent clinical studies

Etiology

Myopic Traction Maculopathy in Low Myopia.
Cole ED, Johnson MW
Ophthalmic Surg Lasers Imaging Retina 2023 Aug;54(8):481-484. Epub 2023 Aug 1 doi: 10.3928/23258160-20230726-01. PMID: 37535608
Ocriplasmin for symptomatic vitreomacular adhesion.
Neffendorf JE, Kirthi V, Pringle E, Jackson TL
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD011874. doi: 10.1002/14651858.CD011874.pub2. PMID: 29040800Free PMC Article
Vitreomacular Adhesion and the Risk of Neovascular Age-Related Macular Degeneration.
Maggio E, Polito A, Guerriero M, Prigione G, Parolini B, Pertile G
Ophthalmology 2017 May;124(5):657-666. Epub 2017 Feb 14 doi: 10.1016/j.ophtha.2017.01.018. PMID: 28214102
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Diagnosis

Myopic Traction Maculopathy in Low Myopia.
Cole ED, Johnson MW
Ophthalmic Surg Lasers Imaging Retina 2023 Aug;54(8):481-484. Epub 2023 Aug 1 doi: 10.3928/23258160-20230726-01. PMID: 37535608
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Symptomatic vitreomacular adhesion.
Jackson TL, Nicod E, Simpson A, Angelis A, Grimaccia F, Kanavos P
Retina 2013 Sep;33(8):1503-11. doi: 10.1097/IAE.0b013e31829232fd. PMID: 23714857
Vitreomacular adhesion and neovascular age-related macular degeneration.
Simpson AR, Petrarca R, Jackson TL
Surv Ophthalmol 2012 Nov;57(6):498-509. doi: 10.1016/j.survophthal.2012.01.011. PMID: 23068973

Therapy

Pharmacotherapy of Vitreomacular Traction.
Wan R, Hong T, Tariq Y, Chang A
Curr Pharm Des 2018;24(41):4874-4881. doi: 10.2174/1381612825666190124102148. PMID: 30674252
Intravitreal gas for symptomatic vitreomacular adhesion: a synthesis of the literature.
Neffendorf JE, Simpson ARH, Steel DHW, Desai R, McHugh DA, Pringle E, Jackson TL
Acta Ophthalmol 2018 Nov;96(7):685-691. Epub 2017 Aug 31 doi: 10.1111/aos.13547. PMID: 28857483
Ocriplasmin for symptomatic vitreomacular adhesion.
Neffendorf JE, Kirthi V, Pringle E, Jackson TL
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD011874. doi: 10.1002/14651858.CD011874.pub2. PMID: 29040800Free PMC Article
The Efficacy and Safety Profile of Ocriplasmin in Vitreomacular Interface Disorders.
Shaikh M, Miller JB, Papakostas TD, Husain D
Semin Ophthalmol 2017;32(1):52-55. Epub 2016 Oct 27 doi: 10.1080/08820538.2016.1228416. PMID: 27786583
Enzymatic Vitrectomy and Pharmacologic Vitreodynamics.
Shah AR, Trese MT
Dev Ophthalmol 2016;55:357-64. Epub 2015 Oct 26 doi: 10.1159/000438962. PMID: 26501959

Prognosis

Ocriplasmin for treatment of vitreomacular traction and macular hole: A systematic literature review and individual participant data meta-analysis of randomized, controlled, double-masked trials.
Jackson TL, Haller J, Blot KH, Duchateau L, Lescrauwaet B
Surv Ophthalmol 2022 May-Jun;67(3):697-711. Epub 2021 Sep 2 doi: 10.1016/j.survophthal.2021.08.003. PMID: 34480895
Age-related macular degeneration: using morphological predictors to modify current treatment protocols.
Ashraf M, Souka A, Adelman RA
Acta Ophthalmol 2018 Mar;96(2):120-133. Epub 2017 Nov 11 doi: 10.1111/aos.13565. PMID: 29130626
Vitreomacular Adhesion and the Risk of Neovascular Age-Related Macular Degeneration.
Maggio E, Polito A, Guerriero M, Prigione G, Parolini B, Pertile G
Ophthalmology 2017 May;124(5):657-666. Epub 2017 Feb 14 doi: 10.1016/j.ophtha.2017.01.018. PMID: 28214102
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Vitreomacular adhesion and neovascular age-related macular degeneration.
Simpson AR, Petrarca R, Jackson TL
Surv Ophthalmol 2012 Nov;57(6):498-509. doi: 10.1016/j.survophthal.2012.01.011. PMID: 23068973

Clinical prediction guides

Intravitreal gas for symptomatic vitreomacular adhesion: a synthesis of the literature.
Neffendorf JE, Simpson ARH, Steel DHW, Desai R, McHugh DA, Pringle E, Jackson TL
Acta Ophthalmol 2018 Nov;96(7):685-691. Epub 2017 Aug 31 doi: 10.1111/aos.13547. PMID: 28857483
Ocriplasmin for symptomatic vitreomacular adhesion.
Neffendorf JE, Kirthi V, Pringle E, Jackson TL
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD011874. doi: 10.1002/14651858.CD011874.pub2. PMID: 29040800Free PMC Article
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995
Symptomatic vitreomacular adhesion.
Jackson TL, Nicod E, Simpson A, Angelis A, Grimaccia F, Kanavos P
Retina 2013 Sep;33(8):1503-11. doi: 10.1097/IAE.0b013e31829232fd. PMID: 23714857

Recent systematic reviews

Evaluating the effect of vitreomacular interface abnormalities on anti-vascular endothelial growth factor treatment outcomes in diabetic macular edema by optical coherence tomography: A systematic review and meta-analysis.
Gong Y, Wang M, Li Q, Shao Y, Li X
Photodiagnosis Photodyn Ther 2023 Jun;42:103555. Epub 2023 Apr 23 doi: 10.1016/j.pdpdt.2023.103555. PMID: 37088331
Ocriplasmin for treatment of vitreomacular traction and macular hole: A systematic literature review and individual participant data meta-analysis of randomized, controlled, double-masked trials.
Jackson TL, Haller J, Blot KH, Duchateau L, Lescrauwaet B
Surv Ophthalmol 2022 May-Jun;67(3):697-711. Epub 2021 Sep 2 doi: 10.1016/j.survophthal.2021.08.003. PMID: 34480895
Ocriplasmin for symptomatic vitreomacular adhesion.
Neffendorf JE, Kirthi V, Pringle E, Jackson TL
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD011874. doi: 10.1002/14651858.CD011874.pub2. PMID: 29040800Free PMC Article
Ocriplasmin use for vitreomacular traction and macular hole: A meta-analysis and comprehensive review on predictive factors for vitreous release and potential complications.
Chatziralli I, Theodossiadis G, Xanthopoulou P, Miligkos M, Sivaprasad S, Theodossiadis P
Graefes Arch Clin Exp Ophthalmol 2016 Jul;254(7):1247-56. Epub 2016 Apr 30 doi: 10.1007/s00417-016-3363-5. PMID: 27137631
Vitreous attachment in age-related macular degeneration, diabetic macular edema, and retinal vein occlusion: a systematic review and metaanalysis.
Jackson TL, Nicod E, Angelis A, Grimaccia F, Prevost AT, Simpson AR, Kanavos P
Retina 2013 Jun;33(6):1099-108. doi: 10.1097/IAE.0b013e31828991d6. PMID: 23591535

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...