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Vitamin K Deficiency Bleeding

MedGen UID:
439355
•Concept ID:
C2718087
•
Disease or Syndrome

Definition

Hemorrhage caused by vitamin K deficiency. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin K Deficiency Bleeding

Professional guidelines

PubMed

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant.
Fiesack S, Smits A, Rayyan M, Allegaert K, Alliet P, Arts W, Bael A, Cornette L, De Guchtenaere A, De Mulder N, George I, Henrion E, Keiren K, Kreins N, Raes M, Philippet P, Van Overmeire B, Van Winckel M, Vlieghe V, Vandenplas Y, On Behalf Of The Groups
Nutrients 2021 Nov 16;13(11) doi: 10.3390/nu13114109. PMID: 34836364Free PMC Article
Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada.
Ng E, Loewy AD
Can Fam Physician 2018 Oct;64(10):736-739. PMID: 30315016Free PMC Article
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domellöf M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9. doi: 10.1097/MPG.0000000000001232. PMID: 27050049

Recent clinical studies

Etiology

Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Haemophilia and the newborn.
Chalmers EA
Blood Rev 2004 Jun;18(2):85-92. doi: 10.1016/S0268-960X(03)00062-6. PMID: 15010147
Giving vitamin K to newborn infants: a therapeutic dilemma.
Henderson-Smart DJ
Med J Aust 1996 Oct 21;165(8):414-5. doi: 10.5694/j.1326-5377.1996.tb138575.x. PMID: 8913240
Vitamin K.
Shearer MJ
Lancet 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9. PMID: 7823718
Vitamin K in infancy.
Lane PA, Hathaway WE
J Pediatr 1985 Mar;106(3):351-9. doi: 10.1016/s0022-3476(85)80656-9. PMID: 3973772

Diagnosis

Personal practice: An approach to investigation of easy bruising.
Vora A, Makris M
Arch Dis Child 2001 Jun;84(6):488-91. doi: 10.1136/adc.84.6.488. PMID: 11369565Free PMC Article
Prenatal determination of fetal blood group status.
Avent ND, Finning KM, Martin PG, Soothill PW
Vox Sang 2000;78 Suppl 2:155-62. PMID: 10938946
Bleeding disorders in neonates.
Pramanik AK
Pediatr Rev 1992 May;13(5):163-73. doi: 10.1542/pir.13-5-163. PMID: 1570246
Prematurity, postmaturity, and destructive lesions in utero.
Rorke LB, Zimmerman RA
AJNR Am J Neuroradiol 1992 Mar-Apr;13(2):517-36. PMID: 1566715Free PMC Article
Haemorrhage in the newborn.
Br Med J 1971 Oct 2;4(5778):1-2. PMID: 5096879Free PMC Article

Therapy

Vitamin K prophylaxis in newborns.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):350. doi: 10.1186/s12887-021-02701-4. PMID: 34496783Free PMC Article
Vitamin K Deficiency Bleeding in Infancy.
Araki S, Shirahata A
Nutrients 2020 Mar 16;12(3) doi: 10.3390/nu12030780. PMID: 32187975Free PMC Article
Vitamin K.
Shearer MJ
Lancet 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9. PMID: 7823718
Coagulation disorders in children.
Bussel JB, Grabowski EF
Curr Opin Pediatr 1993 Feb;5(1):88-93. doi: 10.1097/00008480-199302000-00014. PMID: 8374631
Vitamin K.
Br Med J 1969 Apr 5;2(5648):40. PMID: 5776219Free PMC Article

Prognosis

Vitamin K and the Newborn Infant.
Hand I, Noble L, Abrams SA
Pediatrics 2022 Mar 1;149(3) doi: 10.1542/peds.2021-056036. PMID: 35190810
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
The vitamin K story.
McNinch A
Midwives (1995) 1997 Mar;110(1310):56-8. PMID: 9136433
Posthaemorrhagic hydrocephalus. Diagnosis, differential diagnosis, treatment, and long-term results.
Lorber J, Bhat US
Arch Dis Child 1974 Oct;49(10):751-62. doi: 10.1136/adc.49.10.751. PMID: 4547949Free PMC Article
Perinatal tips.
Zavell PM
Mich Med 1972 Dec;71(35):1008 passim. PMID: 4636888

Clinical prediction guides

Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Haemophilia and the newborn.
Chalmers EA
Blood Rev 2004 Jun;18(2):85-92. doi: 10.1016/S0268-960X(03)00062-6. PMID: 15010147
Vitamin K to neonates. Peroral versus intramuscular administration.
Jørgensen FS, Felding P, Vinther S, Andersen GE
Acta Paediatr Scand 1991 Mar;80(3):304-7. doi: 10.1111/j.1651-2227.1991.tb11853.x. PMID: 2035325
Hemothorax in the newborn.
Oppermann HC, Wille L
Pediatr Radiol 1980 Apr;9(3):129-34. doi: 10.1007/BF01464305. PMID: 7393666
Observations on the prophylactic use of vitamin Kin the newborn infant.
VIETTI TJ, MURPHY TP, JAMES JA, PRITCHARD JA
J Pediatr 1960 Mar;56:343-6. doi: 10.1016/s0022-3476(60)80185-0. PMID: 13842162

Recent systematic reviews

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis.
Zeng L, Choonara I, Zhang L, Li Y, Shi J
Eur J Pediatr 2017 May;176(5):581-589. Epub 2017 Mar 9 doi: 10.1007/s00431-017-2877-0. PMID: 28281092
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Prophylactic vitamin K for vitamin K deficiency bleeding in neonates.
Puckett RM, Offringa M
Cochrane Database Syst Rev 2000;2000(4):CD002776. doi: 10.1002/14651858.CD002776. PMID: 11034761Free PMC Article

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