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Dedifferentiated solitary fibrous tumor

MedGen UID:
396654
•Concept ID:
C2699572
•
Neoplastic Process
Synonyms: Dedifferentiated Solitary Fibrous Tumor; dedifferentiated solitary fibrous tumor
SNOMED CT: Dedifferentiated solitary fibrous tumor (1157181004)
 
Monarch Initiative: MONDO:0006178

Definition

A solitary fibrous tumor characterized by the presence of areas of abrupt transition to high grade sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated solitary fibrous tumor

Professional guidelines

PubMed

Undifferentiated and dedifferentiated soft tissue neoplasms: Immunohistochemical surrogates for differential diagnosis.
Thway K, Fisher C
Semin Diagn Pathol 2021 Nov;38(6):170-186. Epub 2021 Sep 29 doi: 10.1053/j.semdp.2021.09.005. PMID: 34602314
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
A Review of the Surgical Management of Extrathoracic Solitary Fibrous Tumors.
Kayani B, Sharma A, Sewell MD, Platinum J, Olivier A, Briggs TWR, Eastwood DM
Am J Clin Oncol 2018 Jul;41(7):687-694. doi: 10.1097/COC.0000000000000348. PMID: 27893469

Recent clinical studies

Diagnosis

Dedifferentiated Solitary Fibrous Tumor: A Concise Review.
Olson NJ, Linos K
Arch Pathol Lab Med 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS. PMID: 29848035
Multifocal Cytokeratin Expression in a Dedifferentiated Solitary Fibrous Tumor With Heterologous Rhabdomyosarcomatous Differentiation: A Challenging Diagnosis!
Creytens D, Ferdinande L, Van Dorpe J
Int J Surg Pathol 2018 Aug;26(5):423-427. Epub 2018 Feb 27 doi: 10.1177/1066896918758452. PMID: 29482421
Solitary Fibrous Tumor of the Vulva: Report of 2 Cases, Including a De Novo Dedifferentiated Solitary Fibrous Tumor Diagnosed After Molecular Demonstration of NAB2-STAT6 Gene Fusion.
Tardío JC, Machado I, Alemany I, López-Soto MV, Nieto MG, Llombart-Bosch A
Int J Gynecol Pathol 2018 Nov;37(6):547-553. doi: 10.1097/PGP.0000000000000464. PMID: 28968297
A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component.
Maekawa A, Kohashi K, Yamada Y, Nakamizo A, Yoshimoto K, Mizoguchi M, Iwaki T, Oda Y
Neuropathology 2015 Jun;35(3):260-5. Epub 2014 Dec 16 doi: 10.1111/neup.12181. PMID: 25516114

Prognosis

A dedifferentiated intracranial solitary fibrous tumor with osteosarcoma components: rapid tumor progression and lethal clinical course.
Kambe A, Nakada S, Nagao Y, Uno T, Sakamoto M, Shomori K, Tanabe M, Kondo S, Kurosaki M
Brain Tumor Pathol 2020 Oct;37(4):165-170. Epub 2020 Aug 2 doi: 10.1007/s10014-020-00374-y. PMID: 32740753
Dedifferentiated Solitary Fibrous Tumor: A Concise Review.
Olson NJ, Linos K
Arch Pathol Lab Med 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS. PMID: 29848035

Clinical prediction guides

Dedifferentiated Solitary Fibrous Tumor: A Concise Review.
Olson NJ, Linos K
Arch Pathol Lab Med 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS. PMID: 29848035
A case of dedifferentiated solitary fibrous tumor in the pelvis with TP53 mutation.
Kurisaki-Arakawa A, Akaike K, Hara K, Arakawa A, Takahashi M, Mitani K, Yao T, Saito T
Virchows Arch 2014 Nov;465(5):615-21. doi: 10.1007/s00428-014-1625-3. PMID: 25015562
A case of dedifferentiated solitary fibrous tumor of the thoracic cavity.
Masuda Y, Kurisaki-Arakawa A, Hara K, Arakawa A, Oh S, Suzuki K, Yao T, Saito T
Int J Clin Exp Pathol 2014;7(1):386-93. Epub 2013 Dec 15 PMID: 24427361Free PMC Article

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