U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inflammatory bowel disease 14(IBD14)

MedGen UID:
436860
•Concept ID:
C2677100
•
Disease or Syndrome
Synonym: IBD14
 
Gene (location): IRF5 (7q32.1)
 
Monarch Initiative: MONDO:0012832
OMIM®: 612245

Definition

Any inflammatory bowel disease in which the cause of the disease is a mutation in the IRF5 gene. [from MONDO]

Professional guidelines

PubMed

Assessment of the Risk of Venous Thromboembolism in Nonhospitalized Patients With COVID-19.
Fang MC, Reynolds K, Tabada GH, Prasad PA, Sung SH, Parks AL, Garcia E, Portugal C, Fan D, Pai AP, Go AS
JAMA Netw Open 2023 Mar 1;6(3):e232338. doi: 10.1001/jamanetworkopen.2023.2338. PMID: 36912838Free PMC Article

Recent clinical studies

Etiology

Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
Cheng W, Liao Y, Mou R, Xiao X, Jia Y
Front Immunol 2023;14:1157313. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1157313. PMID: 37409117Free PMC Article
Systematic review with network meta-analysis: Risk of Herpes zoster with biological therapies and small molecules in inflammatory bowel disease.
Din S, Selinger CP, Black CJ, Ford AC
Aliment Pharmacol Ther 2023 Mar;57(6):666-675. Epub 2022 Dec 31 doi: 10.1111/apt.17379. PMID: 36585944
Dietary Interventions in Inflammatory Bowel Disease.
Godala M, Gaszyńska E, Zatorski H, Małecka-Wojciesko E
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204261. PMID: 36296945Free PMC Article
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.
Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN
Cell Host Microbe 2021 Aug 11;29(8):1294-1304.e4. Epub 2021 Jul 22 doi: 10.1016/j.chom.2021.06.019. PMID: 34297922Free PMC Article
Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L, Panés J, Sandborn WJ, Vermeire S, Danese S, Feagan BG, Colombel JF, Hanauer SB, Rycroft B
Clin Gastroenterol Hepatol 2016 Mar;14(3):348-354.e17. Epub 2015 Jun 11 doi: 10.1016/j.cgh.2015.06.001. PMID: 26071941

Diagnosis

A bidirectional Mendelian randomization study of sarcopenia-related traits and inflammatory bowel diseases.
Jiao X, Wu WY, Zhan SF, Liu JB, Zhang XJ
Front Immunol 2023;14:1240811. Epub 2023 Nov 8 doi: 10.3389/fimmu.2023.1240811. PMID: 38022582Free PMC Article
The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization.
Xu D, Chen Y, Gao X, Xie W, Wang Y, Shen J, Yang G, Xie B
Front Immunol 2023;14:1148107. Epub 2023 May 18 doi: 10.3389/fimmu.2023.1148107. PMID: 37275908Free PMC Article
Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.
Mörbe UM, Jørgensen PB, Fenton TM, von Burg N, Riis LB, Spencer J, Agace WW
Mucosal Immunol 2021 Jul;14(4):793-802. Epub 2021 Mar 22 doi: 10.1038/s41385-021-00389-4. PMID: 33753873
AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review.
Colombel JF, Shin A, Gibson PR
Clin Gastroenterol Hepatol 2019 Feb;17(3):380-390.e1. Epub 2018 Aug 9 doi: 10.1016/j.cgh.2018.08.001. PMID: 30099108Free PMC Article
Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L, Panés J, Sandborn WJ, Vermeire S, Danese S, Feagan BG, Colombel JF, Hanauer SB, Rycroft B
Clin Gastroenterol Hepatol 2016 Mar;14(3):348-354.e17. Epub 2015 Jun 11 doi: 10.1016/j.cgh.2015.06.001. PMID: 26071941

Therapy

Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
Cheng W, Liao Y, Mou R, Xiao X, Jia Y
Front Immunol 2023;14:1157313. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1157313. PMID: 37409117Free PMC Article
Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives.
Roy S, Dhaneshwar S
World J Gastroenterol 2023 Apr 14;29(14):2078-2100. doi: 10.3748/wjg.v29.i14.2078. PMID: 37122604Free PMC Article
Systematic review with network meta-analysis: Risk of Herpes zoster with biological therapies and small molecules in inflammatory bowel disease.
Din S, Selinger CP, Black CJ, Ford AC
Aliment Pharmacol Ther 2023 Mar;57(6):666-675. Epub 2022 Dec 31 doi: 10.1111/apt.17379. PMID: 36585944
Disturbances of the Gut Microbiota and Microbiota-Derived Metabolites in Inflammatory Bowel Disease.
Hu Y, Chen Z, Xu C, Kan S, Chen D
Nutrients 2022 Dec 2;14(23) doi: 10.3390/nu14235140. PMID: 36501169Free PMC Article
Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease.
Baumgart DC, Le Berre C
N Engl J Med 2021 Sep 30;385(14):1302-1315. doi: 10.1056/NEJMra1907607. PMID: 34587387

Prognosis

Incidence of Inflammatory Bowel Disease in Urban China: A Nationwide Population-based Study.
Xu L, He B, Sun Y, Li J, Shen P, Hu L, Liu G, Wang J, Duan L, Zhan S, Wang S
Clin Gastroenterol Hepatol 2023 Dec;21(13):3379-3386.e29. Epub 2023 Sep 1 doi: 10.1016/j.cgh.2023.08.013. PMID: 37660767
Global Hospitalization Trends for Crohn's Disease and Ulcerative Colitis in the 21st Century: A Systematic Review With Temporal Analyses.
Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JWY, Abreu MT, Rubin DT, Bernstein CN, Banerjee R, Yamamoto-Furusho JK, Panaccione R, Seow CH, Ma C, Underwood FE, Ahuja V, Panaccione N, Shaheen AA, Holroyd-Leduc J, Kaplan GG; Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) Research Group, Balderramo D, Chong VH, Juliao-Baños F, Dutta U, Simadibrata M, Kaibullayeva J, Sun Y, Hilmi I, Raja Ali RA, Paudel MS, Altuwaijri M, Hartono JL, Wei SC, Limsrivilai J, El Ouali S, Vergara BI, Dao VH, Kelly P, Hodges P, Miao Y, Li M
Clin Gastroenterol Hepatol 2023 Aug;21(9):2211-2221. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.06.030. PMID: 35863682
Dietary Interventions in Inflammatory Bowel Disease.
Godala M, Gaszyńska E, Zatorski H, Małecka-Wojciesko E
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204261. PMID: 36296945Free PMC Article
Long-term safety of vedolizumab for inflammatory bowel disease.
Loftus EV Jr, Feagan BG, Panaccione R, Colombel JF, Sandborn WJ, Sands BE, Danese S, D'Haens G, Rubin DT, Shafran I, Parfionovas A, Rogers R, Lirio RA, Vermeire S
Aliment Pharmacol Ther 2020 Oct;52(8):1353-1365. Epub 2020 Sep 2 doi: 10.1111/apt.16060. PMID: 32876349Free PMC Article
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646

Clinical prediction guides

Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease.
Chen J, Ruan X, Sun Y, Lu S, Hu S, Yuan S, Li X
EBioMedicine 2024 Jan;99:104934. Epub 2023 Dec 16 doi: 10.1016/j.ebiom.2023.104934. PMID: 38103512Free PMC Article
Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations.
He R, Zhao S, Cui M, Chen Y, Ma J, Li J, Wang X
Front Immunol 2023;14:1234535. Epub 2023 Oct 26 doi: 10.3389/fimmu.2023.1234535. PMID: 37954590Free PMC Article
Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis.
Cheng W, Liao Y, Mou R, Xiao X, Jia Y
Front Immunol 2023;14:1157313. Epub 2023 Jun 20 doi: 10.3389/fimmu.2023.1157313. PMID: 37409117Free PMC Article
Lipids, lipid-lowering agents, and inflammatory bowel disease: a Mendelian randomization study.
Tao H, Yu Z, Dong Y, Liu L, Peng L, Chen X
Front Immunol 2023;14:1160312. Epub 2023 Jun 7 doi: 10.3389/fimmu.2023.1160312. PMID: 37350960Free PMC Article
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.
Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN
Cell Host Microbe 2021 Aug 11;29(8):1294-1304.e4. Epub 2021 Jul 22 doi: 10.1016/j.chom.2021.06.019. PMID: 34297922Free PMC Article

Recent systematic reviews

High-Fiber Diet and Crohn's Disease: Systematic Review and Meta-Analysis.
Serrano Fernandez V, Seldas Palomino M, Laredo-Aguilera JA, Pozuelo-Carrascosa DP, Carmona-Torres JM
Nutrients 2023 Jul 12;15(14) doi: 10.3390/nu15143114. PMID: 37513532Free PMC Article
Comparative efficacy and safety of biologic therapies for moderate-to-severe Crohn's disease: a systematic review and network meta-analysis.
Singh S, Murad MH, Fumery M, Sedano R, Jairath V, Panaccione R, Sandborn WJ, Ma C
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1002-1014. Epub 2021 Oct 22 doi: 10.1016/S2468-1253(21)00312-5. PMID: 34688373Free PMC Article
Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis.
Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC
Lancet Gastroenterol Hepatol 2021 May;6(5):359-370. Epub 2021 Mar 12 doi: 10.1016/S2468-1253(21)00014-5. PMID: 33721557
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646
ESPEN guideline: Clinical nutrition in inflammatory bowel disease.
Forbes A, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Bischoff SC
Clin Nutr 2017 Apr;36(2):321-347. Epub 2016 Dec 31 doi: 10.1016/j.clnu.2016.12.027. PMID: 28131521

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...