U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inflammatory bowel disease 21(IBD21)

MedGen UID:
436705
Concept ID:
C2676507
Disease or Syndrome
Synonym: IBD21
 
Monarch Initiative: MONDO:0012875
OMIM®: 612354

Definition

An inflammatory bowel disease that has material basis in variation in the chromosome region 18p11. [from MONDO]

Clinical features

From HPO
Ulcerative colitis
MedGen UID:
3532
Concept ID:
C0009324
Disease or Syndrome
A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.

Professional guidelines

PubMed

Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Forbes A, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Bischoff SC
Clin Nutr 2017 Apr;36(2):321-347. Epub 2016 Dec 31 doi: 10.1016/j.clnu.2016.12.027. PMID: 28131521
Hicks CW, Wick EC, Salvatori R, Ha CY
Inflamm Bowel Dis 2015 Jan;21(1):221-8. doi: 10.1097/MIB.0000000000000185. PMID: 25208109

Recent clinical studies

Etiology

Limketkai BN, Godoy-Brewer G, Parian AM, Noorian S, Krishna M, Shah ND, White J, Mullin GE
Clin Gastroenterol Hepatol 2023 Sep;21(10):2508-2525.e10. Epub 2022 Dec 5 doi: 10.1016/j.cgh.2022.11.026. PMID: 36470529
Nambu R, Warner N, Mulder DJ, Kotlarz D, McGovern DPB, Cho J, Klein C, Snapper SB, Griffiths AM, Iwama I, Muise AM
Clin Gastroenterol Hepatol 2022 Apr;20(4):e653-e663. Epub 2021 Mar 18 doi: 10.1016/j.cgh.2021.03.021. PMID: 33746097Free PMC Article
Park J, Cheon JH
Yonsei Med J 2021 Feb;62(2):99-108. doi: 10.3349/ymj.2021.62.2.99. PMID: 33527789Free PMC Article
Windsor JW, Kaplan GG
Curr Gastroenterol Rep 2019 Jul 23;21(8):40. doi: 10.1007/s11894-019-0705-6. PMID: 31338613
Hicks CW, Wick EC, Salvatori R, Ha CY
Inflamm Bowel Dis 2015 Jan;21(1):221-8. doi: 10.1097/MIB.0000000000000185. PMID: 25208109

Diagnosis

Zhang K, Guo J, Yan W, Xu L
Cell Commun Signal 2023 Dec 21;21(1):367. doi: 10.1186/s12964-023-01386-9. PMID: 38129886Free PMC Article
Wang Z, Li S, Tan D, Abudourexiti W, Yu Z, Zhang T, Ding C, Gong J
J Clin Periodontol 2023 Jun;50(6):736-743. Epub 2023 Feb 1 doi: 10.1111/jcpe.13782. PMID: 36697037
Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JWY, Abreu MT, Rubin DT, Bernstein CN, Banerjee R, Yamamoto-Furusho JK, Panaccione R, Seow CH, Ma C, Underwood FE, Ahuja V, Panaccione N, Shaheen AA, Holroyd-Leduc J, Kaplan GG; Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) Research Group, Balderramo D, Chong VH, Juliao-Baños F, Dutta U, Simadibrata M, Kaibullayeva J, Sun Y, Hilmi I, Raja Ali RA, Paudel MS, Altuwaijri M, Hartono JL, Wei SC, Limsrivilai J, El Ouali S, Vergara BI, Dao VH, Kelly P, Hodges P, Miao Y, Li M
Clin Gastroenterol Hepatol 2023 Aug;21(9):2211-2221. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.06.030. PMID: 35863682
Kuenzig ME, Fung SG, Marderfeld L, Mak JWY, Kaplan GG, Ng SC, Wilson DC, Cameron F, Henderson P, Kotze PG, Bhatti J, Fang V, Gerber S, Guay E, Kotteduwa Jayawarden S, Kadota L, Maldonado D F, Osei JA, Sandarage R, Stanton A, Wan M; InsightScope Pediatric IBD Epidemiology Group, Benchimol EI
Gastroenterology 2022 Apr;162(4):1147-1159.e4. Epub 2022 Jan 5 doi: 10.1053/j.gastro.2021.12.282. PMID: 34995526
Vavricka SR, Schoepfer A, Scharl M, Lakatos PL, Navarini A, Rogler G
Inflamm Bowel Dis 2015 Aug;21(8):1982-92. doi: 10.1097/MIB.0000000000000392. PMID: 26154136Free PMC Article

Therapy

Wang Z, Li S, Tan D, Abudourexiti W, Yu Z, Zhang T, Ding C, Gong J
J Clin Periodontol 2023 Jun;50(6):736-743. Epub 2023 Feb 1 doi: 10.1111/jcpe.13782. PMID: 36697037
Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JWY, Abreu MT, Rubin DT, Bernstein CN, Banerjee R, Yamamoto-Furusho JK, Panaccione R, Seow CH, Ma C, Underwood FE, Ahuja V, Panaccione N, Shaheen AA, Holroyd-Leduc J, Kaplan GG; Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) Research Group, Balderramo D, Chong VH, Juliao-Baños F, Dutta U, Simadibrata M, Kaibullayeva J, Sun Y, Hilmi I, Raja Ali RA, Paudel MS, Altuwaijri M, Hartono JL, Wei SC, Limsrivilai J, El Ouali S, Vergara BI, Dao VH, Kelly P, Hodges P, Miao Y, Li M
Clin Gastroenterol Hepatol 2023 Aug;21(9):2211-2221. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.06.030. PMID: 35863682
Ahmed W, Galati J, Kumar A, Christos PJ, Longman R, Lukin DJ, Scherl E, Battat R
Clin Gastroenterol Hepatol 2022 Mar;20(3):e361-e379. Epub 2021 Mar 31 doi: 10.1016/j.cgh.2021.03.034. PMID: 33798711
Kim MH, Kim H
Int J Mol Sci 2017 May 12;18(5) doi: 10.3390/ijms18051051. PMID: 28498331Free PMC Article
Hicks CW, Wick EC, Salvatori R, Ha CY
Inflamm Bowel Dis 2015 Jan;21(1):221-8. doi: 10.1097/MIB.0000000000000185. PMID: 25208109

Prognosis

Xu L, He B, Sun Y, Li J, Shen P, Hu L, Liu G, Wang J, Duan L, Zhan S, Wang S
Clin Gastroenterol Hepatol 2023 Dec;21(13):3379-3386.e29. Epub 2023 Sep 1 doi: 10.1016/j.cgh.2023.08.013. PMID: 37660767
Nambu R, Warner N, Mulder DJ, Kotlarz D, McGovern DPB, Cho J, Klein C, Snapper SB, Griffiths AM, Iwama I, Muise AM
Clin Gastroenterol Hepatol 2022 Apr;20(4):e653-e663. Epub 2021 Mar 18 doi: 10.1016/j.cgh.2021.03.021. PMID: 33746097Free PMC Article
Windsor JW, Kaplan GG
Curr Gastroenterol Rep 2019 Jul 23;21(8):40. doi: 10.1007/s11894-019-0705-6. PMID: 31338613
Vavricka SR, Schoepfer A, Scharl M, Lakatos PL, Navarini A, Rogler G
Inflamm Bowel Dis 2015 Aug;21(8):1982-92. doi: 10.1097/MIB.0000000000000392. PMID: 26154136Free PMC Article
Hicks CW, Wick EC, Salvatori R, Ha CY
Inflamm Bowel Dis 2015 Jan;21(1):221-8. doi: 10.1097/MIB.0000000000000185. PMID: 25208109

Clinical prediction guides

Cai Y, Jia X, Xu L, Chen H, Xie S, Cai J
Front Immunol 2023;14:1238457. Epub 2023 Nov 17 doi: 10.3389/fimmu.2023.1238457. PMID: 38045694Free PMC Article
Gao H, Zheng S, Yuan X, Xie J, Xu L
BMC Med 2023 Oct 10;21(1):389. doi: 10.1186/s12916-023-03096-y. PMID: 37817217Free PMC Article
Tao H, Yu Z, Dong Y, Liu L, Peng L, Chen X
Front Immunol 2023;14:1160312. Epub 2023 Jun 7 doi: 10.3389/fimmu.2023.1160312. PMID: 37350960Free PMC Article
Zhu J, Meng H, Zhang L, Li Y
J Transl Med 2023 Jun 8;21(1):372. doi: 10.1186/s12967-023-04218-z. PMID: 37291580Free PMC Article
Meisinger C, Freuer D
Semin Arthritis Rheum 2022 Aug;55:151992. Epub 2022 Mar 9 doi: 10.1016/j.semarthrit.2022.151992. PMID: 35303571

Recent systematic reviews

Limketkai BN, Godoy-Brewer G, Parian AM, Noorian S, Krishna M, Shah ND, White J, Mullin GE
Clin Gastroenterol Hepatol 2023 Sep;21(10):2508-2525.e10. Epub 2022 Dec 5 doi: 10.1016/j.cgh.2022.11.026. PMID: 36470529
Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JWY, Abreu MT, Rubin DT, Bernstein CN, Banerjee R, Yamamoto-Furusho JK, Panaccione R, Seow CH, Ma C, Underwood FE, Ahuja V, Panaccione N, Shaheen AA, Holroyd-Leduc J, Kaplan GG; Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) Research Group, Balderramo D, Chong VH, Juliao-Baños F, Dutta U, Simadibrata M, Kaibullayeva J, Sun Y, Hilmi I, Raja Ali RA, Paudel MS, Altuwaijri M, Hartono JL, Wei SC, Limsrivilai J, El Ouali S, Vergara BI, Dao VH, Kelly P, Hodges P, Miao Y, Li M
Clin Gastroenterol Hepatol 2023 Aug;21(9):2211-2221. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.06.030. PMID: 35863682
Nambu R, Warner N, Mulder DJ, Kotlarz D, McGovern DPB, Cho J, Klein C, Snapper SB, Griffiths AM, Iwama I, Muise AM
Clin Gastroenterol Hepatol 2022 Apr;20(4):e653-e663. Epub 2021 Mar 18 doi: 10.1016/j.cgh.2021.03.021. PMID: 33746097Free PMC Article
Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC
Lancet Gastroenterol Hepatol 2021 May;6(5):359-370. Epub 2021 Mar 12 doi: 10.1016/S2468-1253(21)00014-5. PMID: 33721557
Forbes A, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Bischoff SC
Clin Nutr 2017 Apr;36(2):321-347. Epub 2016 Dec 31 doi: 10.1016/j.clnu.2016.12.027. PMID: 28131521

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...