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Hypoadiponectinemia

MedGen UID:
382624
•Concept ID:
C2675519
•
Disease or Syndrome

Professional guidelines

PubMed

Adiponectin as a potential therapeutic target for the treatment of restenosis.
Li TD, Zeng ZH
Biomed Pharmacother 2018 May;101:798-804. Epub 2018 Mar 22 doi: 10.1016/j.biopha.2018.03.003. PMID: 29525676
The prevention and treatment of hypoadiponectinemia-associated human diseases by up-regulation of plasma adiponectin.
Hossain MM, Mukheem A, Kamarul T
Life Sci 2015 Aug 15;135:55-67. Epub 2015 Mar 26 doi: 10.1016/j.lfs.2015.03.010. PMID: 25818192
Visceral adiposity as a target for the management of the metabolic syndrome.
Kishida K, Funahashi T, Matsuzawa Y, Shimomura I
Ann Med 2012 May;44(3):233-41. Epub 2011 May 25 doi: 10.3109/07853890.2011.564202. PMID: 21612331

Recent clinical studies

Etiology

Endoplasmic reticulum stress and muscle dysfunction in congenital lipodystrophies.
Araújo de Melo Campos JT, Dantas de Medeiros JL, Cardoso de Melo ME, Alvares da Silva M, Oliveira de Sena M, Sales Craveiro Sarmento A, Fassarella Agnez Lima L, de Freitas Fregonezi GA, Gomes Lima J
Biochim Biophys Acta Mol Basis Dis 2021 Jun 1;1867(6):166120. Epub 2021 Mar 11 doi: 10.1016/j.bbadis.2021.166120. PMID: 33713793
Hypoadiponectinemia--cause or consequence of human "insulin resistance"?
Cook JR, Semple RK
J Clin Endocrinol Metab 2010 Apr;95(4):1544-54. Epub 2010 Feb 17 doi: 10.1210/jc.2009-2286. PMID: 20164291
Hypoadiponectinemia as a marker of adipocyte dysfunction--part II: the functional significance of low adiponectin secretion.
Stern N, Osher E, Greenman Y
J Cardiometab Syndr 2007 Fall;2(4):288-94. doi: 10.1111/j.1559-4564.2007.07297.x. PMID: 18059213
Cardioprotection by adiponectin.
Ouchi N, Shibata R, Walsh K
Trends Cardiovasc Med 2006 Jul;16(5):141-6. doi: 10.1016/j.tcm.2006.03.001. PMID: 16781946Free PMC Article
Adiponectin: protection of the endothelium.
Lam KS, Xu A
Curr Diab Rep 2005 Aug;5(4):254-9. doi: 10.1007/s11892-005-0019-y. PMID: 16033674

Diagnosis

Adiponectin Receptor Agonist Effectively Suppresses Hepatocellular Carcinoma Growth.
Nguyen MLT, Pham C, Pham VT, Nham PLT, Ta BT, Le DT, Le QV, Hoang XC, Bozko P, Nguyen LT, Bui KC
Cell Biochem Biophys 2024 Jun;82(2):687-695. Epub 2024 Jan 20 doi: 10.1007/s12013-024-01217-9. PMID: 38243102
Leptin: Master Regulator of Biological Functions that Affects Breathing.
Gauda EB, Conde S, Bassi M, Zoccal DB, Almeida Colombari DS, Colombari E, Despotovic N
Compr Physiol 2020 Jul 8;10(3):1047-1083. doi: 10.1002/cphy.c190031. PMID: 32941688
Adiponectin and reproduction.
Dos Santos E, Pecquery R, de Mazancourt P, Dieudonné MN
Vitam Horm 2012;90:187-209. doi: 10.1016/B978-0-12-398313-8.00008-7. PMID: 23017717
Nutritional and hormonal modulation of adiponectin and its receptors adipoR1 and adipoR2.
de Oliveira C, de Mattos AB, Silva CB, Mota JF, Zemdegs JC
Vitam Horm 2012;90:57-94. doi: 10.1016/B978-0-12-398313-8.00003-8. PMID: 23017712
Hypoadiponectinemia--cause or consequence of human "insulin resistance"?
Cook JR, Semple RK
J Clin Endocrinol Metab 2010 Apr;95(4):1544-54. Epub 2010 Feb 17 doi: 10.1210/jc.2009-2286. PMID: 20164291

Therapy

Adiponectin Receptor Agonist Effectively Suppresses Hepatocellular Carcinoma Growth.
Nguyen MLT, Pham C, Pham VT, Nham PLT, Ta BT, Le DT, Le QV, Hoang XC, Bozko P, Nguyen LT, Bui KC
Cell Biochem Biophys 2024 Jun;82(2):687-695. Epub 2024 Jan 20 doi: 10.1007/s12013-024-01217-9. PMID: 38243102
Adiponectin, Leptin and Cardiovascular Disorders.
Zhao S, Kusminski CM, Scherer PE
Circ Res 2021 Jan 8;128(1):136-149. Epub 2021 Jan 7 doi: 10.1161/CIRCRESAHA.120.314458. PMID: 33411633Free PMC Article
The prevention and treatment of hypoadiponectinemia-associated human diseases by up-regulation of plasma adiponectin.
Hossain MM, Mukheem A, Kamarul T
Life Sci 2015 Aug 15;135:55-67. Epub 2015 Mar 26 doi: 10.1016/j.lfs.2015.03.010. PMID: 25818192
Modulation of adiponectin as a potential therapeutic strategy.
Lim S, Quon MJ, Koh KK
Atherosclerosis 2014 Apr;233(2):721-728. Epub 2014 Feb 7 doi: 10.1016/j.atherosclerosis.2014.01.051. PMID: 24603219
Hypoadiponectinemia--cause or consequence of human "insulin resistance"?
Cook JR, Semple RK
J Clin Endocrinol Metab 2010 Apr;95(4):1544-54. Epub 2010 Feb 17 doi: 10.1210/jc.2009-2286. PMID: 20164291

Prognosis

Adiponectin Receptor Agonist Effectively Suppresses Hepatocellular Carcinoma Growth.
Nguyen MLT, Pham C, Pham VT, Nham PLT, Ta BT, Le DT, Le QV, Hoang XC, Bozko P, Nguyen LT, Bui KC
Cell Biochem Biophys 2024 Jun;82(2):687-695. Epub 2024 Jan 20 doi: 10.1007/s12013-024-01217-9. PMID: 38243102
Remodeling and Fibrosis of the Cardiac Muscle in the Course of Obesity-Pathogenesis and Involvement of the Extracellular Matrix.
Kruszewska J, Cudnoch-Jedrzejewska A, Czarzasta K
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084195. PMID: 35457013Free PMC Article
Adiponectin, Leptin and Cardiovascular Disorders.
Zhao S, Kusminski CM, Scherer PE
Circ Res 2021 Jan 8;128(1):136-149. Epub 2021 Jan 7 doi: 10.1161/CIRCRESAHA.120.314458. PMID: 33411633Free PMC Article
The role of adiponectin in placentation and preeclampsia.
Adu-Gyamfi EA, Fondjo LA, Owiredu WKBA, Czika A, Nelson W, Lamptey J, Wang YX, Ding YB
Cell Biochem Funct 2020 Jan;38(1):106-117. Epub 2019 Nov 19 doi: 10.1002/cbf.3458. PMID: 31746004
Adiponectin: protection of the endothelium.
Lam KS, Xu A
Curr Diab Rep 2005 Aug;5(4):254-9. doi: 10.1007/s11892-005-0019-y. PMID: 16033674

Clinical prediction guides

Adiponectin, Leptin and Cardiovascular Disorders.
Zhao S, Kusminski CM, Scherer PE
Circ Res 2021 Jan 8;128(1):136-149. Epub 2021 Jan 7 doi: 10.1161/CIRCRESAHA.120.314458. PMID: 33411633Free PMC Article
Modulation of adiponectin as a potential therapeutic strategy.
Lim S, Quon MJ, Koh KK
Atherosclerosis 2014 Apr;233(2):721-728. Epub 2014 Feb 7 doi: 10.1016/j.atherosclerosis.2014.01.051. PMID: 24603219
Adiponectin in diabetes mellitus.
Xita N, Tsatsoulis A
Curr Med Chem 2012;19(32):5451-8. doi: 10.2174/092986712803833182. PMID: 22876922
Obesity-hypertension: an ongoing pandemic.
Francischetti EA, Genelhu VA
Int J Clin Pract 2007 Feb;61(2):269-80. doi: 10.1111/j.1742-1241.2006.01262.x. PMID: 17263714
Adiponectin: protection of the endothelium.
Lam KS, Xu A
Curr Diab Rep 2005 Aug;5(4):254-9. doi: 10.1007/s11892-005-0019-y. PMID: 16033674

Recent systematic reviews

Circulating adiponectin and carotid intima-media thickness: A systematic review and meta-analysis.
Gasbarrino K, Gorgui J, Nauche B, Côté R, Daskalopoulou SS
Metabolism 2016 Jul;65(7):968-86. Epub 2016 Mar 18 doi: 10.1016/j.metabol.2016.03.008. PMID: 27282868
Plasma adiponectin levels in schizophrenia and role of second-generation antipsychotics: a meta-analysis.
Bartoli F, Lax A, Crocamo C, Clerici M, Carrà G
Psychoneuroendocrinology 2015 Jun;56:179-89. Epub 2015 Mar 14 doi: 10.1016/j.psyneuen.2015.03.012. PMID: 25827962
Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Polyzos SA, Toulis KA, Goulis DG, Zavos C, Kountouras J
Metabolism 2011 Mar;60(3):313-26. Epub 2010 Oct 30 doi: 10.1016/j.metabol.2010.09.003. PMID: 21040935

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