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High density lipoprotein cholesterol level quantitative trait locus 12(HDLCQ12)

MedGen UID:
382521
Concept ID:
C2675071
Finding
Synonym: HDLCQ12
 
Gene (location): LIPC (15q21.3)
 
OMIM®: 612797

Recent clinical studies

Etiology

Yu C, Bakshi A, Watts GF, Renton AE, Fulton-Howard B, Goate AM, Natarajan P, Chasman DI, Robman L, Woods RL, Guymer R, Wolfe R, Thao LTP, McNeil JJ, Tonkin AM, Nicholls SJ, Lacaze P
J Am Heart Assoc 2023 Nov 7;12(21):e031459. Epub 2023 Nov 6 doi: 10.1161/JAHA.123.031459. PMID: 37929782Free PMC Article
Shi LJ, Tang X, He J, Shi W
Int J Mol Sci 2022 May 31;23(11) doi: 10.3390/ijms23116184. PMID: 35682864Free PMC Article
Johnson MP, Keyho R, Blackburn NB, Laston S, Kumar S, Peralta J, Thapa SS, Towne B, Subedi J, Blangero J, Williams-Blangero S
J Diabetes Res 2019;2019:2310235. Epub 2019 Apr 4 doi: 10.1155/2019/2310235. PMID: 31089471Free PMC Article
Hong KW, Jeong SW, Chung M, Cho SB
PLoS One 2014;9(12):e114128. Epub 2014 Dec 10 doi: 10.1371/journal.pone.0114128. PMID: 25493549Free PMC Article
Tukiainen T, Kettunen J, Kangas AJ, Lyytikäinen LP, Soininen P, Sarin AP, Tikkanen E, O'Reilly PF, Savolainen MJ, Kaski K, Pouta A, Jula A, Lehtimäki T, Kähönen M, Viikari J, Taskinen MR, Jauhiainen M, Eriksson JG, Raitakari O, Salomaa V, Järvelin MR, Perola M, Palotie A, Ala-Korpela M, Ripatti S
Hum Mol Genet 2012 Mar 15;21(6):1444-55. Epub 2011 Dec 9 doi: 10.1093/hmg/ddr581. PMID: 22156771

Diagnosis

Johnson MP, Keyho R, Blackburn NB, Laston S, Kumar S, Peralta J, Thapa SS, Towne B, Subedi J, Blangero J, Williams-Blangero S
J Diabetes Res 2019;2019:2310235. Epub 2019 Apr 4 doi: 10.1155/2019/2310235. PMID: 31089471Free PMC Article
Grainger AT, Jones MB, Li J, Chen MH, Manichaikul A, Shi W
Atherosclerosis 2016 Nov;254:124-132. Epub 2016 Oct 6 doi: 10.1016/j.atherosclerosis.2016.10.011. PMID: 27736672Free PMC Article
Sarzynski MA, Loos RJ, Lucia A, Pérusse L, Roth SM, Wolfarth B, Rankinen T, Bouchard C
Med Sci Sports Exerc 2016 Oct;48(10):1906-16. doi: 10.1249/MSS.0000000000000982. PMID: 27183119
Zhang Y, Sonnenberg GE, Baye TM, Littrell J, Gunnell J, DeLaForest A, MacKinney E, Hillard CJ, Kissebah AH, Olivier M, Wilke RA
Pharmacogenomics 2009 Dec;10(12):1929-39. doi: 10.2217/pgs.09.122. PMID: 19958092Free PMC Article
Kullo IJ, Ding K, Boerwinkle E, Turner ST, de Andrade M
J Lipid Res 2006 Jul;47(7):1457-62. Epub 2006 Apr 19 doi: 10.1194/jlr.M600078-JLR200. PMID: 16625024

Therapy

Li B, Veturi Y, Verma A, Bradford Y, Daar ES, Gulick RM, Riddler SA, Robbins GK, Lennox JL, Haas DW, Ritchie MD
PLoS Genet 2021 Apr;17(4):e1009464. Epub 2021 Apr 26 doi: 10.1371/journal.pgen.1009464. PMID: 33901188Free PMC Article
van der Graaf A, Claringbould A, Rimbert A; BIOS Consortium, Westra HJ, Li Y, Wijmenga C, Sanna S
Nat Commun 2020 Oct 1;11(1):4930. doi: 10.1038/s41467-020-18716-x. PMID: 33004804Free PMC Article
Grainger AT, Jones MB, Chen MH, Shi W
G3 (Bethesda) 2017 Feb 9;7(2):731-739. doi: 10.1534/g3.116.037879. PMID: 28040783Free PMC Article
Feitosa ME, Rice T, Borecki IB, Rankinen T, Leon AS, Skinner JS, Després JP, Blangero J, Bouchard C, Rao DC
Hum Biol 2006 Jun;78(3):317-27. doi: 10.1353/hub.2006.0043. PMID: 17216804

Prognosis

Yu C, Bakshi A, Watts GF, Renton AE, Fulton-Howard B, Goate AM, Natarajan P, Chasman DI, Robman L, Woods RL, Guymer R, Wolfe R, Thao LTP, McNeil JJ, Tonkin AM, Nicholls SJ, Lacaze P
J Am Heart Assoc 2023 Nov 7;12(21):e031459. Epub 2023 Nov 6 doi: 10.1161/JAHA.123.031459. PMID: 37929782Free PMC Article
Sarzynski MA, Loos RJ, Lucia A, Pérusse L, Roth SM, Wolfarth B, Rankinen T, Bouchard C
Med Sci Sports Exerc 2016 Oct;48(10):1906-16. doi: 10.1249/MSS.0000000000000982. PMID: 27183119
Agirbasli M, Eren F, Agirbasli D, White MJ, Williams SM
OMICS 2013 Dec;17(12):636-45. Epub 2013 Aug 29 doi: 10.1089/omi.2013.0066. PMID: 23988150Free PMC Article
Tukiainen T, Kettunen J, Kangas AJ, Lyytikäinen LP, Soininen P, Sarin AP, Tikkanen E, O'Reilly PF, Savolainen MJ, Kaski K, Pouta A, Jula A, Lehtimäki T, Kähönen M, Viikari J, Taskinen MR, Jauhiainen M, Eriksson JG, Raitakari O, Salomaa V, Järvelin MR, Perola M, Palotie A, Ala-Korpela M, Ripatti S
Hum Mol Genet 2012 Mar 15;21(6):1444-55. Epub 2011 Dec 9 doi: 10.1093/hmg/ddr581. PMID: 22156771
Herrera VL, Didishvili T, Lopez LV, Myers RH, Ruiz-Opazo N
Circ Res 2004 Mar 5;94(4):446-52. Epub 2004 Jan 22 doi: 10.1161/01.RES.0000117770.03168.E7. PMID: 14739155

Clinical prediction guides

Lee S, Kim J, Ohn JH
BMC Genomics 2023 Dec 18;24(1):787. doi: 10.1186/s12864-023-09903-3. PMID: 38110883Free PMC Article
Yu C, Bakshi A, Watts GF, Renton AE, Fulton-Howard B, Goate AM, Natarajan P, Chasman DI, Robman L, Woods RL, Guymer R, Wolfe R, Thao LTP, McNeil JJ, Tonkin AM, Nicholls SJ, Lacaze P
J Am Heart Assoc 2023 Nov 7;12(21):e031459. Epub 2023 Nov 6 doi: 10.1161/JAHA.123.031459. PMID: 37929782Free PMC Article
Johnson MP, Keyho R, Blackburn NB, Laston S, Kumar S, Peralta J, Thapa SS, Towne B, Subedi J, Blangero J, Williams-Blangero S
J Diabetes Res 2019;2019:2310235. Epub 2019 Apr 4 doi: 10.1155/2019/2310235. PMID: 31089471Free PMC Article
Sarzynski MA, Loos RJ, Lucia A, Pérusse L, Roth SM, Wolfarth B, Rankinen T, Bouchard C
Med Sci Sports Exerc 2016 Oct;48(10):1906-16. doi: 10.1249/MSS.0000000000000982. PMID: 27183119
Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL
Am J Hum Genet 2015 Dec 3;97(6):801-15. doi: 10.1016/j.ajhg.2015.10.016. PMID: 26637976Free PMC Article

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