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Trilateral retinoblastoma

MedGen UID:
392856
•Concept ID:
C2608045
•
Neoplastic Process
Synonym: RETINOBLASTOMA, TRILATERAL
 
Monarch Initiative: MONDO:0003073
OMIM®: 614041

Definition

Trilateral retinoblastoma refers to bilateral (or less often unilateral) retinoblastoma associated with an intracranial primitive neuroectodermal tumor in the pineal or suprasellar region. This syndrome is often associated with a increased familial incidence of retinoblastoma. (From Cancer 86(1): 135-141, 1999). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrilateral retinoblastoma

Professional guidelines

PubMed

Clinical audit of retinoblastoma management: a retrospective single-institution study.
Selvarajah A, Flegg K, Sim W, Hu JB, Gallie BL, Shaikh F, Soliman SE, Dimaras H
Can J Ophthalmol 2022 Aug;57(4):257-269. Epub 2021 May 30 doi: 10.1016/j.jcjo.2021.04.019. PMID: 34077747
Current Treatment of Bilateral Retinoblastoma: The Impact of Intraarterial and Intravitreous Chemotherapy.
Francis JH, Roosipu N, Levin AM, Brodie SE, Dunkel IJ, Gobin YP, Abramson DH
Neoplasia 2018 Aug;20(8):757-763. Epub 2018 Jun 22 doi: 10.1016/j.neo.2018.05.007. PMID: 29940303Free PMC Article
Trilateral retinoblastoma: insights into histogenesis and management.
Marcus DM, Brooks SE, Leff G, McCormick R, Thompson T, Anfinson S, Lasudry J, Albert DM
Surv Ophthalmol 1998 Jul-Aug;43(1):59-70. doi: 10.1016/s0039-6257(98)00019-8. PMID: 9716194

Recent clinical studies

Etiology

Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321).
Dunkel IJ, Piao J, Chantada GL, Banerjee A, Abouelnaga S, Buchsbaum JC, Merchant TE, Granger MM, Jubran RF, Weinstein JL, Saguilig L, Abramson DH, Krailo MD, Rodriguez-Galindo C, Chintagumpala MM
J Clin Oncol 2022 Nov 20;40(33):3839-3847. Epub 2022 Jul 12 doi: 10.1200/JCO.21.02337. PMID: 35820112Free PMC Article
Retinoblastoma.
Ortiz MV, Dunkel IJ
J Child Neurol 2016 Feb;31(2):227-36. Epub 2015 May 28 doi: 10.1177/0883073815587943. PMID: 26023180
The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivelä T
Am J Ophthalmol 2015 Dec;160(6):1116-1126.e5. Epub 2015 Sep 12 doi: 10.1016/j.ajo.2015.09.009. PMID: 26374932
Trilateral retinoblastoma: a systematic review and meta-analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivelä T, Moll AC
Lancet Oncol 2014 Sep;15(10):1157-67. Epub 2014 Aug 7 doi: 10.1016/S1470-2045(14)70336-5. PMID: 25126964
Neonatal neoplasms.
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Diagnosis

Retinoblastoma.
Ortiz MV, Dunkel IJ
J Child Neurol 2016 Feb;31(2):227-36. Epub 2015 May 28 doi: 10.1177/0883073815587943. PMID: 26023180
The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivelä T
Am J Ophthalmol 2015 Dec;160(6):1116-1126.e5. Epub 2015 Sep 12 doi: 10.1016/j.ajo.2015.09.009. PMID: 26374932
Trilateral retinoblastoma: a systematic review and meta-analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivelä T, Moll AC
Lancet Oncol 2014 Sep;15(10):1157-67. Epub 2014 Aug 7 doi: 10.1016/S1470-2045(14)70336-5. PMID: 25126964
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703
Trilateral retinoblastoma.
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Therapy

Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321).
Dunkel IJ, Piao J, Chantada GL, Banerjee A, Abouelnaga S, Buchsbaum JC, Merchant TE, Granger MM, Jubran RF, Weinstein JL, Saguilig L, Abramson DH, Krailo MD, Rodriguez-Galindo C, Chintagumpala MM
J Clin Oncol 2022 Nov 20;40(33):3839-3847. Epub 2022 Jul 12 doi: 10.1200/JCO.21.02337. PMID: 35820112Free PMC Article
Minimal disseminated disease evaluation and outcome in trilateral retinoblastoma.
Torbidoni AV, Sampor C, Laurent VE, Aschero R, Iyer S, Rossi J, Alderete D, Alonso DF, Szijan I, Chantada GL
Br J Ophthalmol 2018 Nov;102(11):1597-1601. Epub 2018 Aug 27 doi: 10.1136/bjophthalmol-2018-312263. PMID: 30150278
The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivelä T
Am J Ophthalmol 2015 Dec;160(6):1116-1126.e5. Epub 2015 Sep 12 doi: 10.1016/j.ajo.2015.09.009. PMID: 26374932
Trilateral retinoblastoma: a systematic review and meta-analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivelä T, Moll AC
Lancet Oncol 2014 Sep;15(10):1157-67. Epub 2014 Aug 7 doi: 10.1016/S1470-2045(14)70336-5. PMID: 25126964
Trilateral retinoblastoma.
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Prognosis

Intensive Multimodality Therapy for Extraocular Retinoblastoma: A Children's Oncology Group Trial (ARET0321).
Dunkel IJ, Piao J, Chantada GL, Banerjee A, Abouelnaga S, Buchsbaum JC, Merchant TE, Granger MM, Jubran RF, Weinstein JL, Saguilig L, Abramson DH, Krailo MD, Rodriguez-Galindo C, Chintagumpala MM
J Clin Oncol 2022 Nov 20;40(33):3839-3847. Epub 2022 Jul 12 doi: 10.1200/JCO.21.02337. PMID: 35820112Free PMC Article
Retinoblastoma.
Ortiz MV, Dunkel IJ
J Child Neurol 2016 Feb;31(2):227-36. Epub 2015 May 28 doi: 10.1177/0883073815587943. PMID: 26023180
The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivelä T
Am J Ophthalmol 2015 Dec;160(6):1116-1126.e5. Epub 2015 Sep 12 doi: 10.1016/j.ajo.2015.09.009. PMID: 26374932
Trilateral retinoblastoma: a systematic review and meta-analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivelä T, Moll AC
Lancet Oncol 2014 Sep;15(10):1157-67. Epub 2014 Aug 7 doi: 10.1016/S1470-2045(14)70336-5. PMID: 25126964
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703

Clinical prediction guides

Screening for Pineal Trilateral Retinoblastoma Revisited: A Meta-analysis.
de Jong MC, Kors WA, Moll AC, de Graaf P, Castelijns JA, Jansen RW, Gallie B, Soliman SE, Shaikh F, Dimaras H, Kivelä TT
Ophthalmology 2020 May;127(5):601-607. Epub 2019 Nov 9 doi: 10.1016/j.ophtha.2019.10.040. PMID: 32061409
Retinoblastoma, the visible CNS tumor: A review.
Dimaras H, Corson TW
J Neurosci Res 2019 Jan;97(1):29-44. Epub 2018 Jan 3 doi: 10.1002/jnr.24213. PMID: 29314142Free PMC Article
Minimal disseminated disease evaluation and outcome in trilateral retinoblastoma.
Torbidoni AV, Sampor C, Laurent VE, Aschero R, Iyer S, Rossi J, Alderete D, Alonso DF, Szijan I, Chantada GL
Br J Ophthalmol 2018 Nov;102(11):1597-1601. Epub 2018 Aug 27 doi: 10.1136/bjophthalmol-2018-312263. PMID: 30150278
Retinoblastoma.
Helveston EM, Knuth KR, Ellis FD
J Pediatr Ophthalmol Strabismus 1987 Nov-Dec;24(6):296-300. doi: 10.3928/0191-3913-19871101-07. PMID: 3694385
Bilateral retinoblastoma with ectopic intracranial retinoblastoma: trilateral retinoblastoma.
Bader JL, Meadows AT, Zimmerman LE, Rorke LB, Voute PA, Champion LA, Miller RW
Cancer Genet Cytogenet 1982 Mar;5(3):203-13. doi: 10.1016/0165-4608(82)90026-7. PMID: 7066879

Recent systematic reviews

Trilateral retinoblastoma: A systematic review of 211 cases.
Yamanaka R, Hayano A, Takashima Y
Neurosurg Rev 2019 Mar;42(1):39-48. Epub 2017 Aug 16 doi: 10.1007/s10143-017-0890-4. PMID: 28815312
The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivelä T
Am J Ophthalmol 2015 Dec;160(6):1116-1126.e5. Epub 2015 Sep 12 doi: 10.1016/j.ajo.2015.09.009. PMID: 26374932
Trilateral retinoblastoma: a systematic review and meta-analysis.
de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivelä T, Moll AC
Lancet Oncol 2014 Sep;15(10):1157-67. Epub 2014 Aug 7 doi: 10.1016/S1470-2045(14)70336-5. PMID: 25126964
Retinoblastoma associated with chromosomal 13q14 deletion mosaicism.
Kivelä T, Tuppurainen K, Riikonen P, Vapalahti M
Ophthalmology 2003 Oct;110(10):1983-8. doi: 10.1016/S0161-6420(03)00484-6. PMID: 14522775
Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma.
Kivelä T
J Clin Oncol 1999 Jun;17(6):1829-37. doi: 10.1200/JCO.1999.17.6.1829. PMID: 10561222

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