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Asymptomatic multiple myeloma

MedGen UID:
749367
•Concept ID:
C2585107
•
Neoplastic Process
Synonym: Asymptomatic myeloma
SNOMED CT: Asymptomatic myeloma (440422002); Asymptomatic multiple myeloma (440422002)

Professional guidelines

PubMed

Monoclonal gammopathies of unknown significance and smoldering myeloma: Assessment and management of the elderly patients.
González-Calle V, Mateos MV
Eur J Intern Med 2018 Dec;58:57-63. Epub 2018 Jun 12 doi: 10.1016/j.ejim.2018.05.029. PMID: 29907380
Is it time for preemptive drug treatment of asymptomatic (smoldering) multiple myeloma?
Fawole A, Abonour R, Stender M, Shatavi S, Gaikazian S, Anderson J, Jaiyesimi I
Leuk Lymphoma 2015 Jan;56(1):34-41. Epub 2014 Mar 25 doi: 10.3109/10428194.2014.897702. PMID: 24564573
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article

Recent clinical studies

Etiology

State of the science in smoldering myeloma: Should we be treating in the clinic?
Hill E, Dew A, Kazandjian D
Semin Oncol 2019 Apr;46(2):112-120. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.03.001. PMID: 31072611
Smoldering (asymptomatic) multiple myeloma: revisiting the clinical dilemma and looking into the future.
Waxman AJ, Kuehl M, Balakumaran A, Weiss B, Landgren O
Clin Lymphoma Myeloma Leuk 2010 Aug;10(4):248-57. doi: 10.3816/CLML.2010.n.053. PMID: 20709660Free PMC Article
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article
Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders.
Raja KR, Kovarova L, Hajek R
Br J Haematol 2010 May;149(3):334-51. Epub 2010 Mar 1 doi: 10.1111/j.1365-2141.2010.08121.x. PMID: 20201947
Smoldering (asymptomatic) multiple myeloma: current diagnostic criteria, new predictors of outcome, and follow-up recommendations.
Bladé J, Dimopoulos M, Rosiñol L, Rajkumar SV, Kyle RA
J Clin Oncol 2010 Feb 1;28(4):690-7. Epub 2009 Dec 21 doi: 10.1200/JCO.2009.22.2257. PMID: 20026810Free PMC Article

Diagnosis

State-of-the-Art Imaging and Staging of Plasma Cell Dyscrasias.
Amini B, Yellapragada S, Shah S, Rohren E, Vikram R
Radiol Clin North Am 2016 May;54(3):581-96. Epub 2016 Mar 21 doi: 10.1016/j.rcl.2015.12.008. PMID: 27153790
Extensive bone marrow infiltration and abnormal free light chain ratio identifies patients with asymptomatic myeloma at high risk for progression to symptomatic disease.
Kastritis E, Terpos E, Moulopoulos L, Spyropoulou-Vlachou M, Kanellias N, Eleftherakis-Papaiakovou E, Gkotzamanidou M, Migkou M, Gavriatopoulou M, Roussou M, Tasidou A, Dimopoulos MA
Leukemia 2013 Apr;27(4):947-53. Epub 2012 Nov 6 doi: 10.1038/leu.2012.309. PMID: 23183429
Smoldering (asymptomatic) multiple myeloma: revisiting the clinical dilemma and looking into the future.
Waxman AJ, Kuehl M, Balakumaran A, Weiss B, Landgren O
Clin Lymphoma Myeloma Leuk 2010 Aug;10(4):248-57. doi: 10.3816/CLML.2010.n.053. PMID: 20709660Free PMC Article
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article
Smoldering (asymptomatic) multiple myeloma: current diagnostic criteria, new predictors of outcome, and follow-up recommendations.
Bladé J, Dimopoulos M, Rosiñol L, Rajkumar SV, Kyle RA
J Clin Oncol 2010 Feb 1;28(4):690-7. Epub 2009 Dec 21 doi: 10.1200/JCO.2009.22.2257. PMID: 20026810Free PMC Article

Therapy

Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer.
Bar N, Costa F, Das R, Duffy A, Samur M, McCachren S, Gettinger SN, Neparidze N, Parker TL, Bailur JK, Pendleton K, Bajpai R, Zhang L, Xu ML, Anderson T, Giuliani N, Nooka A, Cho HJ, Raval A, Shanmugam M, Dhodapkar KM, Dhodapkar MV
JCI Insight 2020 Jun 18;5(12) doi: 10.1172/jci.insight.129353. PMID: 32427579Free PMC Article
State of the science in smoldering myeloma: Should we be treating in the clinic?
Hill E, Dew A, Kazandjian D
Semin Oncol 2019 Apr;46(2):112-120. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.03.001. PMID: 31072611
Monoclonal gammopathies of unknown significance and smoldering myeloma: Assessment and management of the elderly patients.
González-Calle V, Mateos MV
Eur J Intern Med 2018 Dec;58:57-63. Epub 2018 Jun 12 doi: 10.1016/j.ejim.2018.05.029. PMID: 29907380
Recurrent extramedullary plasmacytoma in asymptomatic multiple myeloma: a case report.
Schols SE, Tick LL
J Med Case Rep 2015 Feb 19;9:37. doi: 10.1186/s13256-014-0506-3. PMID: 25880694Free PMC Article
Is it time for preemptive drug treatment of asymptomatic (smoldering) multiple myeloma?
Fawole A, Abonour R, Stender M, Shatavi S, Gaikazian S, Anderson J, Jaiyesimi I
Leuk Lymphoma 2015 Jan;56(1):34-41. Epub 2014 Mar 25 doi: 10.3109/10428194.2014.897702. PMID: 24564573

Prognosis

State of the science in smoldering myeloma: Should we be treating in the clinic?
Hill E, Dew A, Kazandjian D
Semin Oncol 2019 Apr;46(2):112-120. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.03.001. PMID: 31072611
Smoldering (asymptomatic) multiple myeloma: revisiting the clinical dilemma and looking into the future.
Waxman AJ, Kuehl M, Balakumaran A, Weiss B, Landgren O
Clin Lymphoma Myeloma Leuk 2010 Aug;10(4):248-57. doi: 10.3816/CLML.2010.n.053. PMID: 20709660Free PMC Article
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management.
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article
Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders.
Raja KR, Kovarova L, Hajek R
Br J Haematol 2010 May;149(3):334-51. Epub 2010 Mar 1 doi: 10.1111/j.1365-2141.2010.08121.x. PMID: 20201947
Smoldering (asymptomatic) multiple myeloma: current diagnostic criteria, new predictors of outcome, and follow-up recommendations.
Bladé J, Dimopoulos M, Rosiñol L, Rajkumar SV, Kyle RA
J Clin Oncol 2010 Feb 1;28(4):690-7. Epub 2009 Dec 21 doi: 10.1200/JCO.2009.22.2257. PMID: 20026810Free PMC Article

Clinical prediction guides

Defining genomic events involved in the evolutionary trajectories of myeloma and its precursor conditions.
Chojnacka M, Diamond B, Landgren O, Maura F
Semin Oncol 2022 Feb;49(1):11-18. Epub 2022 Jan 31 doi: 10.1053/j.seminoncol.2022.01.006. PMID: 35168813Free PMC Article
Monoclonal gammopathies of unknown significance and smoldering myeloma: Assessment and management of the elderly patients.
González-Calle V, Mateos MV
Eur J Intern Med 2018 Dec;58:57-63. Epub 2018 Jun 12 doi: 10.1016/j.ejim.2018.05.029. PMID: 29907380
Smoldering (asymptomatic) multiple myeloma: revisiting the clinical dilemma and looking into the future.
Waxman AJ, Kuehl M, Balakumaran A, Weiss B, Landgren O
Clin Lymphoma Myeloma Leuk 2010 Aug;10(4):248-57. doi: 10.3816/CLML.2010.n.053. PMID: 20709660Free PMC Article
Smoldering (asymptomatic) multiple myeloma: current diagnostic criteria, new predictors of outcome, and follow-up recommendations.
Bladé J, Dimopoulos M, Rosiñol L, Rajkumar SV, Kyle RA
J Clin Oncol 2010 Feb 1;28(4):690-7. Epub 2009 Dec 21 doi: 10.1200/JCO.2009.22.2257. PMID: 20026810Free PMC Article
Incidence and follow-up of asymptomatic multiple myeloma. The myeloma project of health region I in Norway. II.
Wisløff F, Andersen P, Andersson TR, Brandt E, Eika C, Fjaestad K, Grønvold T, Holm B, Løvåsen K, Tjønnfjord GE
Eur J Haematol 1991 Nov;47(5):338-41. doi: 10.1111/j.1600-0609.1991.tb01857.x. PMID: 1761119

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