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Childhood Depression

MedGen UID:
473582
•Concept ID:
C2363919
•
Mental or Behavioral Dysfunction

Definition

Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Depression

Professional guidelines

PubMed

Screening for Depression in Pediatric Primary Care.
Forman-Hoffman VL, Viswanathan M
Curr Psychiatry Rep 2018 Jul 23;20(8):62. doi: 10.1007/s11920-018-0926-7. PMID: 30039275
Treatment of anxiety and depression in the preschool period.
Luby JL
J Am Acad Child Adolesc Psychiatry 2013 Apr;52(4):346-58. doi: 10.1016/j.jaac.2013.01.011. PMID: 23582866Free PMC Article
Diagnosis and treatment of dysthymia in children and adolescents.
Nobile M, Cataldo GM, Marino C, Molteni M
CNS Drugs 2003;17(13):927-46. doi: 10.2165/00023210-200317130-00001. PMID: 14533944

Recent clinical studies

Etiology

Childhood-onset depression and arterial stiffness in young adulthood.
Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M
J Psychosom Res 2021 Sep;148:110551. Epub 2021 Jun 17 doi: 10.1016/j.jpsychores.2021.110551. PMID: 34174712Free PMC Article
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article
Depression in children.
Kapornai K, Vetró A
Curr Opin Psychiatry 2008 Jan;21(1):1-7. doi: 10.1097/YCO.0b013e3282f25b01. PMID: 18281833
Understanding childhood depression.
Malhotra S, Das PP
Indian J Med Res 2007 Feb;125(2):115-28. PMID: 17431280
Childhood and adolescent depression.
Bhatia SK, Bhatia SC
Am Fam Physician 2007 Jan 1;75(1):73-80. PMID: 17225707

Diagnosis

Childhood-onset depression and arterial stiffness in young adulthood.
Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M
J Psychosom Res 2021 Sep;148:110551. Epub 2021 Jun 17 doi: 10.1016/j.jpsychores.2021.110551. PMID: 34174712Free PMC Article
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article
Childhood and adolescent depression.
Bhatia SK, Bhatia SC
Am Fam Physician 2007 Jan 1;75(1):73-80. PMID: 17225707
Childhood depression: Be on the alert.
Nelms BC
J Pediatr Health Care 2003 Jul-Aug;17(4):161-2. doi: 10.1067/mph.2003.57. PMID: 12847424
Childhood depression.
Kazdin AE
J Child Psychol Psychiatry 1990 Jan;31(1):121-60. doi: 10.1111/j.1469-7610.1990.tb02276.x. PMID: 2179245

Therapy

Adiposity and Smoking Mediate the Relationship Between Depression History and Inflammation Among Young Adults.
Yang X, Evans RW, George CJ, Matthews KA, Kovacs M
Int J Behav Med 2022 Dec;29(6):787-795. Epub 2022 Feb 9 doi: 10.1007/s12529-022-10060-2. PMID: 35141821
Development and efficacy of a family-focused treatment for depression in childhood.
Tompson MC, Langer DA, Asarnow JR
J Affect Disord 2020 Nov 1;276:686-695. Epub 2020 Jul 14 doi: 10.1016/j.jad.2020.06.057. PMID: 32871701Free PMC Article
Depression in children.
Kapornai K, Vetró A
Curr Opin Psychiatry 2008 Jan;21(1):1-7. doi: 10.1097/YCO.0b013e3282f25b01. PMID: 18281833
Childhood and adolescent depression.
Bhatia SK, Bhatia SC
Am Fam Physician 2007 Jan 1;75(1):73-80. PMID: 17225707
Childhood depression.
Kazdin AE
J Child Psychol Psychiatry 1990 Jan;31(1):121-60. doi: 10.1111/j.1469-7610.1990.tb02276.x. PMID: 2179245

Prognosis

Childhood-onset depression and arterial stiffness in young adulthood.
Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M
J Psychosom Res 2021 Sep;148:110551. Epub 2021 Jun 17 doi: 10.1016/j.jpsychores.2021.110551. PMID: 34174712Free PMC Article
Development and efficacy of a family-focused treatment for depression in childhood.
Tompson MC, Langer DA, Asarnow JR
J Affect Disord 2020 Nov 1;276:686-695. Epub 2020 Jul 14 doi: 10.1016/j.jad.2020.06.057. PMID: 32871701Free PMC Article
Early childhood depression, emotion regulation, episodic memory, and hippocampal development.
Barch DM, Harms MP, Tillman R, Hawkey E, Luby JL
J Abnorm Psychol 2019 Jan;128(1):81-95. doi: 10.1037/abn0000392. PMID: 30628810Free PMC Article
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article
Childhood depression.
Wiener JM, Hendren RL
J Dev Behav Pediatr 1983 Mar;4(1):43-9. doi: 10.1097/00004703-198303000-00009. PMID: 6833504

Clinical prediction guides

Functional connectivity analysis of childhood depressive symptoms.
Huang P, Chan SY, Ngoh ZM, Nadarajan R, Chong YS, Gluckman PD, Chen H, Fortier MV, Tan AP, Meaney MJ
Neuroimage Clin 2023;38:103395. Epub 2023 Apr 6 doi: 10.1016/j.nicl.2023.103395. PMID: 37031637Free PMC Article
Depression in 3/6-year-old children: clinical and psychosocial outcomes in later childhood and adolescence.
Silver J, Olino TM, Carlson GA, Dougherty LR, Bufferd SJ, Klein DN
J Child Psychol Psychiatry 2022 Sep;63(9):984-991. Epub 2021 Dec 2 doi: 10.1111/jcpp.13553. PMID: 34859433
Childhood-onset depression and arterial stiffness in young adulthood.
Barinas-Mitchell E, Yang X, Matthews KA, Columbus ML, George CJ, Dósa E, Kiss E, Kapornai K, Evans R, Kovacs M
J Psychosom Res 2021 Sep;148:110551. Epub 2021 Jun 17 doi: 10.1016/j.jpsychores.2021.110551. PMID: 34174712Free PMC Article
Development and efficacy of a family-focused treatment for depression in childhood.
Tompson MC, Langer DA, Asarnow JR
J Affect Disord 2020 Nov 1;276:686-695. Epub 2020 Jul 14 doi: 10.1016/j.jad.2020.06.057. PMID: 32871701Free PMC Article
Developmental risk factors in generalized anxiety disorder and panic disorder.
Newman MG, Shin KE, Zuellig AR
J Affect Disord 2016 Dec;206:94-102. Epub 2016 Jul 5 doi: 10.1016/j.jad.2016.07.008. PMID: 27466747Free PMC Article

Recent systematic reviews

Review: What Outcomes Count? A Review of Outcomes Measured for Adolescent Depression Between 2007 and 2017.
Krause KR, Bear HA, Edbrooke-Childs J, Wolpert M
J Am Acad Child Adolesc Psychiatry 2019 Jan;58(1):61-71. Epub 2018 Oct 29 doi: 10.1016/j.jaac.2018.07.893. PMID: 30577940
Exposure to violence in breast cancer patients: systematic review.
Aygin D, Bozdemir H
Breast Cancer 2019 Jan;26(1):29-38. Epub 2018 Aug 22 doi: 10.1007/s12282-018-0900-6. PMID: 30136077
Preventing depression in the offspring of parents with depression: A systematic review and meta-analysis of randomized controlled trials.
Loechner J, Starman K, Galuschka K, Tamm J, Schulte-Körne G, Rubel J, Platt B
Clin Psychol Rev 2018 Mar;60:1-14. Epub 2017 Nov 29 doi: 10.1016/j.cpr.2017.11.009. PMID: 29305152
Retinal vascular imaging in early life: insights into processes and risk of cardiovascular disease.
Li LJ, Ikram MK, Wong TY
J Physiol 2016 Apr 15;594(8):2175-203. Epub 2015 Nov 23 doi: 10.1113/JP270947. PMID: 26435039Free PMC Article
Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data.
Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E
Lancet 2004 Apr 24;363(9418):1341-5. doi: 10.1016/S0140-6736(04)16043-1. PMID: 15110490

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