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Adult Erythroleukemia

MedGen UID:
389533
•Concept ID:
C2347748
•
Neoplastic Process

Definition

An erythroleukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Erythroleukemia

Professional guidelines

PubMed

Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases.
Reichard KK, Tefferi A, Abdelmagid M, Orazi A, Alexandres C, Haack J, Greipp PT
Blood Cancer J 2022 Nov 2;12(11):147. doi: 10.1038/s41408-022-00746-x. PMID: 36323674Free PMC Article
Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study.
Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Diez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L
Int J Mol Sci 2017 Apr 14;18(4) doi: 10.3390/ijms18040837. PMID: 28420120Free PMC Article
Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature.
Atkinson J, Hrisinko MA, Weil SC
Blood Rev 1992 Dec;6(4):204-14. doi: 10.1016/0268-960x(92)90016-j. PMID: 1486289

Recent clinical studies

Etiology

Effects of Ruxolitinib on Immune Checkpoint Molecule Expression in JAK2 V617F-Positive Cells.
Fu J, Cheng Z, Zhang L, Wen X, Hao J
Clin Lab 2024 Oct 1;70(10) doi: 10.7754/Clin.Lab.2024.240340. PMID: 39382932
Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia.
Kapralova K, Jahoda O, Koralkova P, Gursky J, Lanikova L, Pospisilova D, Divoky V, Horvathova M
Int J Mol Sci 2020 Dec 17;21(24) doi: 10.3390/ijms21249652. PMID: 33348919Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition.
Zerella JR, Homan CC, Arts P, Lin X, Spinelli SJ, Venugopal P, Babic M, Brautigan PJ, Truong L, Arriola-Martinez L, Moore S, Hollins R, Parker WT, Nguyen H, Kassahn KS, Branford S, Feurstein S, Larcher L, Sicre de Fontbrune F, Demirdas S, de Munnik S, Antoine-Poirel H, Brichard B, Mansour S, Gordon K, Wlodarski MW, Koppayi A, Dobbins S, Mutsaers PGNJ, Nichols KE, Oak N, DeMille D, Mao R, Crawford A, McCarrier J, Basel D, Flores-Daboub J, Drazer MW, Phillips K, Poplawski NK, Birdsey GM, Pirri D, Ostergaard P, Simons A, Godley LA, Ross DM, Hiwase DK, Soulier J, Brown AL, Carmichael CL, Scott HS, Hahn CN
Blood 2024 Oct 24;144(17):1765-1780. doi: 10.1182/blood.2024024607. PMID: 38991192Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Acute erythroleukemia--M6B.
Mohanty R, Dash B, Chawla SC, Paul HS
Indian J Pathol Microbiol 2001 Oct;44(4):461-2. PMID: 12035366
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440
The myeloproliferative disorders.
Gilbert HS, Dameshek W
Dis Mon 1970 Oct:1-52. doi: 10.1016/s0011-5029(70)80012-8. PMID: 4921953

Therapy

Effects of Ruxolitinib on Immune Checkpoint Molecule Expression in JAK2 V617F-Positive Cells.
Fu J, Cheng Z, Zhang L, Wen X, Hao J
Clin Lab 2024 Oct 1;70(10) doi: 10.7754/Clin.Lab.2024.240340. PMID: 39382932
Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria.
Blouin JM, Ged C, Lalanne M, Lamrissi-Garcia I, Morice-Picard F, Costet P, Daher R, Moreau-Gaudry F, Bedel A, Puy H, Gouya L, Karim Z, Richard E
Blood 2020 Nov 19;136(21):2457-2468. doi: 10.1182/blood.2020006037. PMID: 32678895
Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.
Briot T, Roger E, Bou Haidar N, Bejaud J, Lautram N, Guillet C, Thépot S, Legeay S, Lagarce F
Int J Nanomedicine 2019;14:2091-2102. Epub 2019 Mar 26 doi: 10.2147/IJN.S190482. PMID: 30988610Free PMC Article
Subacute anthracycline cardiotoxicity.
Hengel CL, Russell PA, Gould PA, Kaye DM
Heart Lung Circ 2006 Feb;15(1):59-61. Epub 2005 Nov 11 doi: 10.1016/j.hlc.2005.06.003. PMID: 16473794
Myeloproliferative diseases in childhood.
Nix WL, Fernbach DJ
Am J Pediatr Hematol Oncol 1981 Winter;3(4):397-407. PMID: 6174053

Prognosis

Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.
Briot T, Roger E, Bou Haidar N, Bejaud J, Lautram N, Guillet C, Thépot S, Legeay S, Lagarce F
Int J Nanomedicine 2019;14:2091-2102. Epub 2019 Mar 26 doi: 10.2147/IJN.S190482. PMID: 30988610Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Erythroleukemia: a need for a new definition.
Park S, Picard F, Dreyfus F
Leukemia 2002 Aug;16(8):1399-401. doi: 10.1038/sj.leu.2402549. PMID: 12145675
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457
Cytogenetic analysis in leukemia.
Meisner LF
CRC Crit Rev Clin Lab Sci 1975 Oct;6(3):157-200. doi: 10.3109/10408367509151570. PMID: 1104261

Clinical prediction guides

Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Cytogenetic study of 75 erythroleukemias.
Lessard M, Struski S, Leymarie V, Flandrin G, Lafage-Pochitaloff M, Mozziconacci MJ, Talmant P, Bastard C, Charrin C, Baranger L, Hélias C, Cornillet-Lefebvre P, Mugneret F, Cabrol C, Pagès MP, Fert-Ferret D, Nguyen-Khac F, Quilichini B, Barin C, Berger R; Groupe Francophone de Cytogénétique Hématologique (GFCH)
Cancer Genet Cytogenet 2005 Dec;163(2):113-22. doi: 10.1016/j.cancergencyto.2005.05.006. PMID: 16337853
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165
Transcription factor GATA-1 and erythroid development.
Simon MC
Proc Soc Exp Biol Med 1993 Feb;202(2):115-21. doi: 10.3181/00379727-202-43519a. PMID: 8424101
Erythroid cell differentiation.
Forget BG, Glass J, Housman D
Hamatol Bluttransfus 1976;19:109-24. doi: 10.1007/978-3-642-87524-3_12. PMID: 1070457

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