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Generalized muscle wasting

MedGen UID:
810989
•Concept ID:
C2219809
•
Sign or Symptom

Professional guidelines

PubMed

A Review of Sarcopenia Pathophysiology, Diagnosis, Treatment and Future Direction.
Cho MR, Lee S, Song SK
J Korean Med Sci 2022 May 9;37(18):e146. doi: 10.3346/jkms.2022.37.e146. PMID: 35535373Free PMC Article
Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment.
Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H
J Am Med Dir Assoc 2020 Mar;21(3):300-307.e2. Epub 2020 Feb 4 doi: 10.1016/j.jamda.2019.12.012. PMID: 32033882
ESPEN guidelines on definitions and terminology of clinical nutrition.
Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, Compher C, Correia I, Higashiguchi T, Holst M, Jensen GL, Malone A, Muscaritoli M, Nyulasi I, Pirlich M, Rothenberg E, Schindler K, Schneider SM, de van der Schueren MA, Sieber C, Valentini L, Yu JC, Van Gossum A, Singer P
Clin Nutr 2017 Feb;36(1):49-64. Epub 2016 Sep 14 doi: 10.1016/j.clnu.2016.09.004. PMID: 27642056

Recent clinical studies

Etiology

Advanced cancer is also a heart failure syndrome: a hypothesis.
Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, Coats AJS, Anker SD
J Cachexia Sarcopenia Muscle 2021 Jun;12(3):533-537. Epub 2021 Mar 18 doi: 10.1002/jcsm.12694. PMID: 33734609Free PMC Article
Advanced cancer is also a heart failure syndrome: a hypothesis.
Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, Coats AJS, Anker SD
Eur J Heart Fail 2021 Jan;23(1):140-144. doi: 10.1002/ejhf.2071. PMID: 33247608

Diagnosis

Expanding the clinical and metabolic phenotype of DPM2 deficient congenital disorders of glycosylation.
Radenkovic S, Fitzpatrick-Schmidt T, Byeon SK, Madugundu AK, Saraswat M, Lichty A, Wong SYW, McGee S, Kubiak K, Ligezka A, Ranatunga W, Zhang Y, Wood T, Friez MJ, Clarkson K, Pandey A, Jones JR, Morava E
Mol Genet Metab 2021 Jan;132(1):27-37. Epub 2020 Oct 17 doi: 10.1016/j.ymgme.2020.10.007. PMID: 33129689Free PMC Article
Presentation of parathyroid adenoma with genu valgum and thoracic deformities.
Zil-E-Ali A, Latif A, Rashid A, Malik A, Khan HA
J Pak Med Assoc 2016 Jan;66(1):101-3. PMID: 26712192
Budd-Chiari syndrome.
Bhuiyan MR, Ahmed M, Azad AK, Mostafa MG, Sultana A, Abdullah AM
Mymensingh Med J 2012 Oct;21(4):755-8. PMID: 23134931
Mitochondrial neurogastrointestinal encephalopathy in an Indian family with possible manifesting carriers of heterozygous TYMP mutation.
Nalini A, Gayathri N
J Neurol Sci 2011 Oct 15;309(1-2):131-5. Epub 2011 Jul 26 doi: 10.1016/j.jns.2011.06.052. PMID: 21794876
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Ochala J, Larsson L
Exp Physiol 2008 Apr;93(4):486-95. Epub 2008 Feb 1 doi: 10.1113/expphysiol.2007.041798. PMID: 18245202

Therapy

Hematin and propranolol in acute intermittent porphyria. Full recovery from quadriplegic coma and respiratory failure.
Brezis M, Ghanem J, Weiler-Ravell D, Epstein O, Morris D
Eur Neurol 1979;18(5):289-94. doi: 10.1159/000115092. PMID: 527604

Prognosis

Advanced cancer is also a heart failure syndrome: a hypothesis.
Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, Coats AJS, Anker SD
J Cachexia Sarcopenia Muscle 2021 Jun;12(3):533-537. Epub 2021 Mar 18 doi: 10.1002/jcsm.12694. PMID: 33734609Free PMC Article
Advanced cancer is also a heart failure syndrome: a hypothesis.
Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, Coats AJS, Anker SD
Eur J Heart Fail 2021 Jan;23(1):140-144. doi: 10.1002/ejhf.2071. PMID: 33247608
X-linked myotubular myopathy: a case report of prenatal and perinatal aspects.
Tyson RW, Ringel SP, Manchester DK, Shikes RH, Goodman SI
Pediatr Pathol 1992 Jul-Aug;12(4):535-43. doi: 10.3109/15513819209024203. PMID: 1409152

Clinical prediction guides

Advanced cancer is also a heart failure syndrome: a hypothesis.
Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, Coats AJS, Anker SD
J Cachexia Sarcopenia Muscle 2021 Jun;12(3):533-537. Epub 2021 Mar 18 doi: 10.1002/jcsm.12694. PMID: 33734609Free PMC Article
Advanced cancer is also a heart failure syndrome: a hypothesis.
Anker MS, Sanz AP, Zamorano JL, Mehra MR, Butler J, Riess H, Coats AJS, Anker SD
Eur J Heart Fail 2021 Jan;23(1):140-144. doi: 10.1002/ejhf.2071. PMID: 33247608
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Ochala J, Larsson L
Exp Physiol 2008 Apr;93(4):486-95. Epub 2008 Feb 1 doi: 10.1113/expphysiol.2007.041798. PMID: 18245202
Hyperinsulinism and neuromuscular disorders; a consideration of the association of pancreatic adenoma with wasting states.
BARRIS RW
Calif Med 1953 Mar;78(3):224-6. PMID: 13032800Free PMC Article

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