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Meningeal Lymphoma

MedGen UID:
453225
•Concept ID:
C2213017
•
Neoplastic Process
Synonyms: Leptomeningeal Lymphoma; Lymphomatous Meningitis

Definition

Involvement of the meninges by Hodgkin or non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

The management of meningeal lymphoma in patients with HIV in the era of HAART: intrathecal depot cytarabine is effective and safe.
Mazhar D, Stebbing J, Lewis R, Nelson M, Gazzard BG, Bower M
Blood 2006 Apr 15;107(8):3412-4. doi: 10.1182/blood-2005-08-3119. PMID: 16597601

Recent clinical studies

Etiology

A dose-dense short-term therapy for human immunodeficiency virus/acquired immunodeficiency syndrome patients with high-risk Burkitt lymphoma or high-grade B-cell lymphoma: safety and efficacy results of the "CARMEN" phase II trial.
Ferreri AJM, Cattaneo C, Lleshi A, Verga L, Allione B, Facchetti F, Ponzoni M, Foppoli M, Ferrari D, Rigacci L, Pecciarini L, Donadoni G, Fumagalli L, Sassone M, Calimeri T, Rossi G, Spina M, Re A
Br J Haematol 2021 Jan;192(1):119-128. Epub 2020 Oct 21 doi: 10.1111/bjh.17188. PMID: 33085777
Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.
Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M
J Clin Oncol 2007 Apr 10;25(11):1350-6. Epub 2007 Feb 20 doi: 10.1200/JCO.2006.09.7311. PMID: 17312328
Role of magnetic resonance imaging in the diagnosis of bilateral facial paralysis.
Ramsey KL, Kaseff LG
Am J Otol 1993 Nov;14(6):605-9. PMID: 8296867
Burkitt's lymphoma in the Middle East. A study of 34 cases.
Anaissie E, Geha S, Allam C, Jabbour J, Khalyl M, Salem P
Cancer 1985 Nov 15;56(10):2539-43. doi: 10.1002/1097-0142(19851115)56:10<2539::aid-cncr2820561038>3.0.co;2-5. PMID: 4042076
CNS involvement in the non-Hodgkin's lymphomas.
Levitt LJ, Dawson DM, Rosenthal DS, Moloney WC
Cancer 1980 Feb;45(3):545-52. doi: 10.1002/1097-0142(19800201)45:3<545::aid-cncr2820450322>3.0.co;2-6. PMID: 6986199

Diagnosis

MRI restricted diffusion in lymphomatous optic neuropathy.
Sudhakar P, Rodriguez FR, Trobe JD
J Neuroophthalmol 2011 Dec;31(4):306-9. doi: 10.1097/WNO.0b013e31821ee581. PMID: 21623229
Borrelia meningitis mimicking meningeal lymphoma.
García-Moncó JC, Gómez Beldarrain M, Benach JL, Anda P, Alvarez J, Ojanguren J
Neurology 1994 Nov;44(11):2207. doi: 10.1212/wnl.44.11.2207. PMID: 7969989
Spontaneous remission of a third-nerve palsy in meningeal lymphoma.
Galetta SL, Sergott RC, Wells GB, Atlas SW, Bird SJ
Ann Neurol 1992 Jul;32(1):100-2. doi: 10.1002/ana.410320117. PMID: 1642461
CSF beta-glucuronidase assay in the diagnosis of neoplastic meningitis.
Shuttleworth E, Allen N
Arch Neurol 1980 Nov;37(11):684-7. doi: 10.1001/archneur.1980.00500600032003. PMID: 7436807
Cryptococcal meningitis with false-positive cytology in the CSF. Use of T-cell rosetting to exclude meningeal lymphoma.
Davies SF, Gormus BJ, Yarchoan R, Kaplan ME
JAMA 1978 Jun 2;239(22):2369-70. doi: 10.1001/jama.239.22.2369. PMID: 347115

Therapy

A dose-dense short-term therapy for human immunodeficiency virus/acquired immunodeficiency syndrome patients with high-risk Burkitt lymphoma or high-grade B-cell lymphoma: safety and efficacy results of the "CARMEN" phase II trial.
Ferreri AJM, Cattaneo C, Lleshi A, Verga L, Allione B, Facchetti F, Ponzoni M, Foppoli M, Ferrari D, Rigacci L, Pecciarini L, Donadoni G, Fumagalli L, Sassone M, Calimeri T, Rossi G, Spina M, Re A
Br J Haematol 2021 Jan;192(1):119-128. Epub 2020 Oct 21 doi: 10.1111/bjh.17188. PMID: 33085777
MRI restricted diffusion in lymphomatous optic neuropathy.
Sudhakar P, Rodriguez FR, Trobe JD
J Neuroophthalmol 2011 Dec;31(4):306-9. doi: 10.1097/WNO.0b013e31821ee581. PMID: 21623229
Primary meningeal CNS lymphoma treated with intra-arterial chemotherapy and blood-brain barrier disruption.
Macnealy MW, Newton HB, McGregor JM, Bell SD, Ray Chaudhury A, Slone HW, Bourekas EC
J Neurooncol 2008 Dec;90(3):329-33. Epub 2008 Aug 30 doi: 10.1007/s11060-008-9667-5. PMID: 18758913
Low-grade primary meningeal lymphoma: case report and review of the literature.
Menniti A, Moschettoni L, Liccardo G, Lunardi P
Neurosurg Rev 2005 Jul;28(3):229-33. Epub 2005 Jan 29 doi: 10.1007/s10143-004-0373-2. PMID: 15682333
Difference in CDDP penetration into CSF between selective intraarterial chemotherapy in patients with malignant glioma and intravenous or intracarotid administration in patients with metastatic brain tumor.
Nakagawa H, Fujita T, Kubo S, Tokiyoshi K, Yamada M, Kanayama T, Hagiwara Y, Nakanomyo H, Hiraoka M
Cancer Chemother Pharmacol 1996;37(4):317-26. doi: 10.1007/s002800050391. PMID: 8548876

Prognosis

Primary meningeal lymphoma of T-cell origin: a rare presentation of primary central nervous system lymphomas.
Ponce J, Segura A, Gimenez A, Diaz R, Molina J, Palomar L, Codina JG
Clin Lymphoma Myeloma 2007 Sep;7(8):546-9. doi: 10.3816/clm.2007.n.041. PMID: 18021474
Spontaneous remission of a third-nerve palsy in meningeal lymphoma.
Galetta SL, Sergott RC, Wells GB, Atlas SW, Bird SJ
Ann Neurol 1992 Jul;32(1):100-2. doi: 10.1002/ana.410320117. PMID: 1642461
Measurements of CSF biochemical tumor markers in patients with meningeal carcinomatosis and brain tumors.
Nakagawa H, Kubo S, Murasawa A, Nakajima S, Nakajima Y, Izumoto S, Hayakawa T
J Neurooncol 1992 Feb;12(2):111-20. doi: 10.1007/BF00172659. PMID: 1560255
Burkitt's lymphoma in the Middle East. A study of 34 cases.
Anaissie E, Geha S, Allam C, Jabbour J, Khalyl M, Salem P
Cancer 1985 Nov 15;56(10):2539-43. doi: 10.1002/1097-0142(19851115)56:10<2539::aid-cncr2820561038>3.0.co;2-5. PMID: 4042076
CNS involvement in the non-Hodgkin's lymphomas.
Levitt LJ, Dawson DM, Rosenthal DS, Moloney WC
Cancer 1980 Feb;45(3):545-52. doi: 10.1002/1097-0142(19800201)45:3<545::aid-cncr2820450322>3.0.co;2-6. PMID: 6986199

Clinical prediction guides

Cytotoxic hepatosplenic gammadelta T-cell lymphoma following acute myeloid leukemia bearing two distinct gamma chains of the T-cell receptor. Biologic and clinical features.
Weidmann E, Hinz T, Klein S, Schui DK, Harder S, Kriener S, Kabelitz D, Hoelzer D, Mitrou PS
Haematologica 2000 Oct;85(10):1024-31. PMID: 11025592
Primary meningeal lymphoma presenting solely with blindness: a report of an autopsy case.
Sakai C, Takagi T, Wakatsuki S
Int J Hematol 1996 Jun;63(4):325-9. doi: 10.1016/0925-5710(96)00453-7. PMID: 8762816
Measurements of CSF biochemical tumor markers in patients with meningeal carcinomatosis and brain tumors.
Nakagawa H, Kubo S, Murasawa A, Nakajima S, Nakajima Y, Izumoto S, Hayakawa T
J Neurooncol 1992 Feb;12(2):111-20. doi: 10.1007/BF00172659. PMID: 1560255
Burkitt's lymphoma in the Middle East. A study of 34 cases.
Anaissie E, Geha S, Allam C, Jabbour J, Khalyl M, Salem P
Cancer 1985 Nov 15;56(10):2539-43. doi: 10.1002/1097-0142(19851115)56:10<2539::aid-cncr2820561038>3.0.co;2-5. PMID: 4042076
Pharmacokinetics of vincristine in the cerebrospinal fluid of humans.
Jackson DV Jr, Sethi VS, Spurr CL, McWhorter JM
Cancer Res 1981 Apr;41(4):1466-8. PMID: 6260340

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