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Epidermal growth factor receptor positive non-small cell lung cancer

MedGen UID:
743681
•Concept ID:
C1960925
•
Neoplastic Process
Synonyms: EGF-R positive non-small cell lung cancer; EGFR positive non-small cell lung cancer; Non-small cell lung cancer, positive for epidermal growth factor receptor expression
SNOMED CT: Non-small cell lung cancer, positive for epidermal growth factor receptor expression (426964009); EGF-R positive non-small cell lung cancer (426964009); EGFR positive non-small cell lung cancer (426964009); Epidermal growth factor receptor positive non-small cell lung cancer (426964009)

Professional guidelines

PubMed

Small cell lung cancer transformation: From pathogenesis to treatment.
Yin X, Li Y, Wang H, Jia T, Wang E, Luo Y, Wei Y, Qin Z, Ma X
Semin Cancer Biol 2022 Nov;86(Pt 2):595-606. Epub 2022 Mar 8 doi: 10.1016/j.semcancer.2022.03.006. PMID: 35276343
Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review).
He J, Huang Z, Han L, Gong Y, Xie C
Int J Oncol 2021 Nov;59(5) Epub 2021 Sep 24 doi: 10.3892/ijo.2021.5270. PMID: 34558640Free PMC Article
Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer.
Wu SG, Shih JY
Mol Cancer 2018 Feb 19;17(1):38. doi: 10.1186/s12943-018-0777-1. PMID: 29455650Free PMC Article

Recent clinical studies

Etiology

Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Saw SPL, Zhou S, Chen J, Lai G, Ang MK, Chua K, Kanesvaran R, Ng QS, Jain A, Tan WL, Rajasekaran T, Lim DWT, Tan A, Fong KW, Takano A, Cheng XM, Lim KH, Koh T, Ong BH, Tan EH, Toh CK, Skanderup AJ, Tan SH, Tan DSW
JAMA Netw Open 2021 Nov 1;4(11):e2131892. doi: 10.1001/jamanetworkopen.2021.31892. PMID: 34739062Free PMC Article
Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment.
Provencio M, Serna-Blasco R, Franco F, Calvo V, Royuela A, Auglytė M, Sánchez-Hernández A, de Julián Campayo M, García-Girón C, Dómine M, Blasco A, Sánchez JM, Oramas J, Bosch-Barrera J, Sala MÁ, Sereno M, Ortega AL, Chara L, Hernández B, Padilla A, Coves J, Blanco R, Balsalobre J, Mielgo X, Bueno C, Jantus-Lewintre E, Molina-Vila MÁ, Romero A
Eur J Cancer 2021 May;149:61-72. Epub 2021 Apr 5 doi: 10.1016/j.ejca.2021.02.031. PMID: 33831609
Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Chen M, Xu Y, Zhao J, Zhong W, Zhang L, Bi Y, Wang M
EBioMedicine 2019 Apr;42:304-310. Epub 2019 Mar 14 doi: 10.1016/j.ebiom.2019.03.023. PMID: 30878600Free PMC Article
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.
Cappuzzo F, Varella-Garcia M, Shigematsu H, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Gregorc V, Toschi L, Franklin WA, Crino L, Gazdar AF, Bunn PA Jr, Hirsch FR
J Clin Oncol 2005 Aug 1;23(22):5007-18. doi: 10.1200/JCO.2005.09.111. PMID: 16051952

Diagnosis

Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Saw SPL, Zhou S, Chen J, Lai G, Ang MK, Chua K, Kanesvaran R, Ng QS, Jain A, Tan WL, Rajasekaran T, Lim DWT, Tan A, Fong KW, Takano A, Cheng XM, Lim KH, Koh T, Ong BH, Tan EH, Toh CK, Skanderup AJ, Tan SH, Tan DSW
JAMA Netw Open 2021 Nov 1;4(11):e2131892. doi: 10.1001/jamanetworkopen.2021.31892. PMID: 34739062Free PMC Article
Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment.
Provencio M, Serna-Blasco R, Franco F, Calvo V, Royuela A, Auglytė M, Sánchez-Hernández A, de Julián Campayo M, García-Girón C, Dómine M, Blasco A, Sánchez JM, Oramas J, Bosch-Barrera J, Sala MÁ, Sereno M, Ortega AL, Chara L, Hernández B, Padilla A, Coves J, Blanco R, Balsalobre J, Mielgo X, Bueno C, Jantus-Lewintre E, Molina-Vila MÁ, Romero A
Eur J Cancer 2021 May;149:61-72. Epub 2021 Apr 5 doi: 10.1016/j.ejca.2021.02.031. PMID: 33831609
Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Chen M, Xu Y, Zhao J, Zhong W, Zhang L, Bi Y, Wang M
EBioMedicine 2019 Apr;42:304-310. Epub 2019 Mar 14 doi: 10.1016/j.ebiom.2019.03.023. PMID: 30878600Free PMC Article
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.
Cappuzzo F, Varella-Garcia M, Shigematsu H, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Gregorc V, Toschi L, Franklin WA, Crino L, Gazdar AF, Bunn PA Jr, Hirsch FR
J Clin Oncol 2005 Aug 1;23(22):5007-18. doi: 10.1200/JCO.2005.09.111. PMID: 16051952

Therapy

Erlotinib with or without bevacizumab as a first-line therapy for patients with advanced nonsquamous epidermal growth factor receptor-positive non-small cell lung cancer: Exploratory subgroup analyses from the phase II JO25567 study.
Hosomi Y, Seto T, Nishio M, Goto K, Yamamoto N, Okamoto I, Tajima K, Kajihara Y, Yamamoto N
Thorac Cancer 2022 Aug;13(15):2192-2200. Epub 2022 Jun 29 doi: 10.1111/1759-7714.14541. PMID: 35768976Free PMC Article
Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Saw SPL, Zhou S, Chen J, Lai G, Ang MK, Chua K, Kanesvaran R, Ng QS, Jain A, Tan WL, Rajasekaran T, Lim DWT, Tan A, Fong KW, Takano A, Cheng XM, Lim KH, Koh T, Ong BH, Tan EH, Toh CK, Skanderup AJ, Tan SH, Tan DSW
JAMA Netw Open 2021 Nov 1;4(11):e2131892. doi: 10.1001/jamanetworkopen.2021.31892. PMID: 34739062Free PMC Article
Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment.
Provencio M, Serna-Blasco R, Franco F, Calvo V, Royuela A, Auglytė M, Sánchez-Hernández A, de Julián Campayo M, García-Girón C, Dómine M, Blasco A, Sánchez JM, Oramas J, Bosch-Barrera J, Sala MÁ, Sereno M, Ortega AL, Chara L, Hernández B, Padilla A, Coves J, Blanco R, Balsalobre J, Mielgo X, Bueno C, Jantus-Lewintre E, Molina-Vila MÁ, Romero A
Eur J Cancer 2021 May;149:61-72. Epub 2021 Apr 5 doi: 10.1016/j.ejca.2021.02.031. PMID: 33831609
Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Chen M, Xu Y, Zhao J, Zhong W, Zhang L, Bi Y, Wang M
EBioMedicine 2019 Apr;42:304-310. Epub 2019 Mar 14 doi: 10.1016/j.ebiom.2019.03.023. PMID: 30878600Free PMC Article
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients.
Cappuzzo F, Varella-Garcia M, Shigematsu H, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Gregorc V, Toschi L, Franklin WA, Crino L, Gazdar AF, Bunn PA Jr, Hirsch FR
J Clin Oncol 2005 Aug 1;23(22):5007-18. doi: 10.1200/JCO.2005.09.111. PMID: 16051952

Prognosis

Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment.
Provencio M, Serna-Blasco R, Franco F, Calvo V, Royuela A, Auglytė M, Sánchez-Hernández A, de Julián Campayo M, García-Girón C, Dómine M, Blasco A, Sánchez JM, Oramas J, Bosch-Barrera J, Sala MÁ, Sereno M, Ortega AL, Chara L, Hernández B, Padilla A, Coves J, Blanco R, Balsalobre J, Mielgo X, Bueno C, Jantus-Lewintre E, Molina-Vila MÁ, Romero A
Eur J Cancer 2021 May;149:61-72. Epub 2021 Apr 5 doi: 10.1016/j.ejca.2021.02.031. PMID: 33831609
Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Chen M, Xu Y, Zhao J, Zhong W, Zhang L, Bi Y, Wang M
EBioMedicine 2019 Apr;42:304-310. Epub 2019 Mar 14 doi: 10.1016/j.ebiom.2019.03.023. PMID: 30878600Free PMC Article

Clinical prediction guides

Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment.
Provencio M, Serna-Blasco R, Franco F, Calvo V, Royuela A, Auglytė M, Sánchez-Hernández A, de Julián Campayo M, García-Girón C, Dómine M, Blasco A, Sánchez JM, Oramas J, Bosch-Barrera J, Sala MÁ, Sereno M, Ortega AL, Chara L, Hernández B, Padilla A, Coves J, Blanco R, Balsalobre J, Mielgo X, Bueno C, Jantus-Lewintre E, Molina-Vila MÁ, Romero A
Eur J Cancer 2021 May;149:61-72. Epub 2021 Apr 5 doi: 10.1016/j.ejca.2021.02.031. PMID: 33831609
Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer.
Chen M, Xu Y, Zhao J, Zhong W, Zhang L, Bi Y, Wang M
EBioMedicine 2019 Apr;42:304-310. Epub 2019 Mar 14 doi: 10.1016/j.ebiom.2019.03.023. PMID: 30878600Free PMC Article

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