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Osteophyte of bone

MedGen UID:
363093
•Concept ID:
C1956089
•
Disease or Syndrome
Synonyms: Bone Spur; Bone Spurs; Osteophyte; Osteophytes; Spur, Bone; Spurs, Bone
SNOMED CT: Osteophyte (88998003); Bony spur (88998003); Osteophyma (88998003); Osteophyte of bone (235231000119100); Bone spur (235231000119100)

Definition

A bony projection that forms on the joints of the body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteophyte of bone

Professional guidelines

PubMed

Healthcare and Scientific Treatment of Knee Osteoarthritis.
Wang H, Ma B
J Healthc Eng 2022;2022:5919686. Epub 2022 Jan 28 doi: 10.1155/2022/5919686. PMID: 35126931Free PMC Article
Pathogenesis and management of pain in osteoarthritis.
Dieppe PA, Lohmander LS
Lancet 2005 Mar 12-18;365(9463):965-73. doi: 10.1016/S0140-6736(05)71086-2. PMID: 15766999
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.
Altman R, Alarcón G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Feldman D
Arthritis Rheum 1991 May;34(5):505-14. doi: 10.1002/art.1780340502. PMID: 2025304

Recent clinical studies

Etiology

Arthroscopic Treatment of Anterior Ankle Impingement.
Dujela MD, Houng BE
Clin Podiatr Med Surg 2023 Jul;40(3):397-411. Epub 2023 Feb 16 doi: 10.1016/j.cpm.2022.12.001. PMID: 37236678
Development of osteoarthritis in patients with degenerative meniscal tears treated with exercise therapy or surgery: a randomized controlled trial.
Berg B, Roos EM, Englund M, Kise NJ, Tiulpin A, Saarakkala S, Engebretsen L, Eftang CN, Holm I, Risberg MA
Osteoarthritis Cartilage 2020 Jul;28(7):897-906. Epub 2020 Mar 14 doi: 10.1016/j.joca.2020.01.020. PMID: 32184135
Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial.
Beard DJ, Rees JL, Cook JA, Rombach I, Cooper C, Merritt N, Shirkey BA, Donovan JL, Gwilym S, Savulescu J, Moser J, Gray A, Jepson M, Tracey I, Judge A, Wartolowska K, Carr AJ; CSAW Study Group
Lancet 2018 Jan 27;391(10118):329-338. Epub 2017 Nov 20 doi: 10.1016/S0140-6736(17)32457-1. PMID: 29169668Free PMC Article
Review Article: Osteophytes.
Wong SH, Chiu KY, Yan CH
J Orthop Surg (Hong Kong) 2016 Dec;24(3):403-410. doi: 10.1177/1602400327. PMID: 28031516
Atlas of radiographic features of osteoarthritis of the ankle and hindfoot.
Kraus VB, Kilfoil TM, Hash TW 2nd, McDaniel G, Renner JB, Carrino JA, Adams S
Osteoarthritis Cartilage 2015 Dec;23(12):2059-2085. Epub 2015 Aug 28 doi: 10.1016/j.joca.2015.08.008. PMID: 26318654Free PMC Article

Diagnosis

MRI of difficult discs.
Waindim F, Crim J
Clin Radiol 2023 Mar;78(3):201-208. Epub 2022 Dec 17 doi: 10.1016/j.crad.2022.11.009. PMID: 36535826
Myelopathy.
Oyinkan Marquis B, Capone PM
Handb Clin Neurol 2016;136:1015-26. doi: 10.1016/B978-0-444-53486-6.00052-1. PMID: 27430455
The olecranon spur.
Reilly D, Kamineni S
J Shoulder Elbow Surg 2015 Jun;24(6):980-7. doi: 10.1016/j.jse.2015.03.002. PMID: 25979555
Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score).
Hunter DJ, Guermazi A, Lo GH, Grainger AJ, Conaghan PG, Boudreau RM, Roemer FW
Osteoarthritis Cartilage 2011 Aug;19(8):990-1002. Epub 2011 May 23 doi: 10.1016/j.joca.2011.05.004. PMID: 21645627Free PMC Article
Pathogenesis and management of pain in osteoarthritis.
Dieppe PA, Lohmander LS
Lancet 2005 Mar 12-18;365(9463):965-73. doi: 10.1016/S0140-6736(05)71086-2. PMID: 15766999

Therapy

5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis.
Kim J, Ryu G, Seo J, Go M, Kim G, Yi S, Kim S, Lee H, Lee JY, Kim HS, Park MC, Shin DH, Shim H, Kim W, Lee SY
Nat Commun 2024 Feb 3;15(1):1024. doi: 10.1038/s41467-024-45174-6. PMID: 38310093Free PMC Article
Development of osteoarthritis in patients with degenerative meniscal tears treated with exercise therapy or surgery: a randomized controlled trial.
Berg B, Roos EM, Englund M, Kise NJ, Tiulpin A, Saarakkala S, Engebretsen L, Eftang CN, Holm I, Risberg MA
Osteoarthritis Cartilage 2020 Jul;28(7):897-906. Epub 2020 Mar 14 doi: 10.1016/j.joca.2020.01.020. PMID: 32184135
Metformin limits osteoarthritis development and progression through activation of AMPK signalling.
Li J, Zhang B, Liu WX, Lu K, Pan H, Wang T, Oh CD, Yi D, Huang J, Zhao L, Ning G, Xing C, Xiao G, Liu-Bryan R, Feng S, Chen D
Ann Rheum Dis 2020 May;79(5):635-645. Epub 2020 Mar 10 doi: 10.1136/annrheumdis-2019-216713. PMID: 32156705Free PMC Article
Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial.
Beard DJ, Rees JL, Cook JA, Rombach I, Cooper C, Merritt N, Shirkey BA, Donovan JL, Gwilym S, Savulescu J, Moser J, Gray A, Jepson M, Tracey I, Judge A, Wartolowska K, Carr AJ; CSAW Study Group
Lancet 2018 Jan 27;391(10118):329-338. Epub 2017 Nov 20 doi: 10.1016/S0140-6736(17)32457-1. PMID: 29169668Free PMC Article
Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score).
Hunter DJ, Guermazi A, Lo GH, Grainger AJ, Conaghan PG, Boudreau RM, Roemer FW
Osteoarthritis Cartilage 2011 Aug;19(8):990-1002. Epub 2011 May 23 doi: 10.1016/j.joca.2011.05.004. PMID: 21645627Free PMC Article

Prognosis

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers.
Zeng J, Jiang X, Jiang M, Cao Y, Jiang Y
Sci Rep 2023 Dec 21;13(1):22894. doi: 10.1038/s41598-023-48446-1. PMID: 38129488Free PMC Article
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.
Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D
Cell Death Dis 2021 May 18;12(6):504. doi: 10.1038/s41419-021-03792-8. PMID: 34006826Free PMC Article
Arthroscopic partial meniscectomy for a degenerative meniscus tear: a 5 year follow-up of the placebo-surgery controlled FIDELITY (Finnish Degenerative Meniscus Lesion Study) trial.
Sihvonen R, Paavola M, Malmivaara A, Itälä A, Joukainen A, Kalske J, Nurmi H, Kumm J, Sillanpää N, Kiekara T, Turkiewicz A, Toivonen P, Englund M, Taimela S, Järvinen TLN; FIDELITY (Finnish Degenerative Meniscus Lesion Study) Investigators
Br J Sports Med 2020 Nov;54(22):1332-1339. Epub 2020 Aug 27 doi: 10.1136/bjsports-2020-102813. PMID: 32855201Free PMC Article
Development of osteoarthritis in patients with degenerative meniscal tears treated with exercise therapy or surgery: a randomized controlled trial.
Berg B, Roos EM, Englund M, Kise NJ, Tiulpin A, Saarakkala S, Engebretsen L, Eftang CN, Holm I, Risberg MA
Osteoarthritis Cartilage 2020 Jul;28(7):897-906. Epub 2020 Mar 14 doi: 10.1016/j.joca.2020.01.020. PMID: 32184135
Postvertebroplasty instability.
Nagad P, Rawall S, Kundnani V, Mohan K, Patil SS, Nene A
J Neurosurg Spine 2012 Apr;16(4):387-93. Epub 2012 Jan 6 doi: 10.3171/2011.12.SPINE11671. PMID: 22225486

Clinical prediction guides

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Brylka LJ, Alimy AR, Tschaffon-Müller MEA, Jiang S, Ballhause TM, Baranowsky A, von Kroge S, Delsmann J, Pawlus E, Eghbalian K, Püschel K, Schoppa A, Haffner-Luntzer M, Beech DJ, Beil FT, Amling M, Keller J, Ignatius A, Yorgan TA, Rolvien T, Schinke T
Bone Res 2024 Feb 23;12(1):12. doi: 10.1038/s41413-024-00315-x. PMID: 38395992Free PMC Article
Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial.
Beard DJ, Rees JL, Cook JA, Rombach I, Cooper C, Merritt N, Shirkey BA, Donovan JL, Gwilym S, Savulescu J, Moser J, Gray A, Jepson M, Tracey I, Judge A, Wartolowska K, Carr AJ; CSAW Study Group
Lancet 2018 Jan 27;391(10118):329-338. Epub 2017 Nov 20 doi: 10.1016/S0140-6736(17)32457-1. PMID: 29169668Free PMC Article
Atlas of radiographic features of osteoarthritis of the ankle and hindfoot.
Kraus VB, Kilfoil TM, Hash TW 2nd, McDaniel G, Renner JB, Carrino JA, Adams S
Osteoarthritis Cartilage 2015 Dec;23(12):2059-2085. Epub 2015 Aug 28 doi: 10.1016/j.joca.2015.08.008. PMID: 26318654Free PMC Article
Hand osteoarthritis--a heterogeneous disorder.
Kloppenburg M, Kwok WY
Nat Rev Rheumatol 2011 Nov 22;8(1):22-31. doi: 10.1038/nrrheum.2011.170. PMID: 22105244
Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score).
Hunter DJ, Guermazi A, Lo GH, Grainger AJ, Conaghan PG, Boudreau RM, Roemer FW
Osteoarthritis Cartilage 2011 Aug;19(8):990-1002. Epub 2011 May 23 doi: 10.1016/j.joca.2011.05.004. PMID: 21645627Free PMC Article

Recent systematic reviews

Vertebral artery stenosis from osteophyte: A systematic review and case series.
Ndongo Sonfack DJ, Bojanowski MW, Tarabay B, Gennari A, Shédid D, Yuh SJ
Neurochirurgie 2024 May;70(3):101525. Epub 2024 Jan 29 doi: 10.1016/j.neuchi.2023.101525. PMID: 38277863
Functional manifestations of early knee osteoarthritis: a systematic review and meta-analysis.
Shimizu H, Shimoura K, Iijima H, Suzuki Y, Aoyama T
Clin Rheumatol 2022 Sep;41(9):2625-2634. Epub 2022 May 12 doi: 10.1007/s10067-022-06150-x. PMID: 35554743
The role of patelloplasty in total knee arthroplasty.
Cerciello S, Robin J, Lustig S, Maccauro G, Heyse TJ, Neyret P
Arch Orthop Trauma Surg 2016 Nov;136(11):1607-1613. Epub 2016 Sep 29 doi: 10.1007/s00402-016-2577-7. PMID: 27687176
A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis.
Barr AJ, Campbell TM, Hopkinson D, Kingsbury SR, Bowes MA, Conaghan PG
Arthritis Res Ther 2015 Aug 25;17(1):228. doi: 10.1186/s13075-015-0735-x. PMID: 26303219Free PMC Article
Defining the inherent stability of degenerative spondylolisthesis: a systematic review.
Simmonds AM, Rampersaud YR, Dvorak MF, Dea N, Melnyk AD, Fisher CG
J Neurosurg Spine 2015 Aug;23(2):178-89. Epub 2015 May 15 doi: 10.3171/2014.11.SPINE1426. PMID: 25978079

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