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Bile duct papillary neoplasm

MedGen UID:
360303
•Concept ID:
C1879344
•
Neoplastic Process
Synonyms: Bile Duct Intraductal Papillary Neoplasm; Bile Duct IPN; bile duct papillary epithelial neoplasm; bile duct papillary neoplasm; Bile Duct Papillomatosis; bile duct papillomatosis; Biliary papillomatosis; Biliary Papillomatosis; biliary papillomatosis; intraductal papillary neoplasm; IPN
SNOMED CT: Biliary papillomatosis (128663007); Biliary papillomatosis (1187632006)
 
Monarch Initiative: MONDO:0003455

Definition

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. [from NCI]

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
Primary Liver Cancers-Part 1: Histopathology, Differential Diagnoses, and Risk Stratification.
Jiang K, Al-Diffhala S, Centeno BA
Cancer Control 2018 Jan-Mar;25(1):1073274817744625. doi: 10.1177/1073274817744625. PMID: 29350068Free PMC Article

Recent clinical studies

Etiology

Biliary papillomatosis.
Gelders F, Struyve M, van Malenstein H
Acta Gastroenterol Belg 2023 Jul-Sep;86(3):483-485. doi: 10.51821/86.3.11733. PMID: 37814564
The World Health Organization Reporting System for Pancreaticobiliary Cytopathology.
Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G
Cancer Cytopathol 2023 Jan;131(1):37-49. Epub 2022 Aug 30 doi: 10.1002/cncy.22637. PMID: 36041224Free PMC Article
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.
Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996
Premalignant Lesions of the Biliary Tract.
Kanji ZS, Rocha FG
Surg Clin North Am 2019 Apr;99(2):301-314. Epub 2019 Feb 10 doi: 10.1016/j.suc.2018.11.007. PMID: 30846036

Diagnosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G
Cancer Cytopathol 2023 Jan;131(1):37-49. Epub 2022 Aug 30 doi: 10.1002/cncy.22637. PMID: 36041224Free PMC Article
Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct.
Sakai Y, Ohtsuka M, Sugiyama H, Mikata R, Yasui S, Ohno I, Iino Y, Kato J, Tsuyuguchi T, Kato N
World J Gastroenterol 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569. PMID: 33958844Free PMC Article
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.
Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996

Therapy

Endoscopic ampullectomy: a technical review.
Espinel J, Pinedo E, Ojeda V, Guerra Del Río M
Rev Esp Enferm Dig 2016 May;108(5):271-8. doi: 10.17235/reed.2016.3867/2015. PMID: 27187501
Per oral cholangiopancreatoscopy in pancreatico biliary diseases--expert consensus statements.
Ramchandani M, Reddy DN, Lakhtakia S, Tandan M, Maydeo A, Chandrashekhar TS, Kumar A, Sud R, Rerknimitr R, Makmun D, Khor C
World J Gastroenterol 2015 Apr 21;21(15):4722-34. doi: 10.3748/wjg.v21.i15.4722. PMID: 25914484Free PMC Article
Endoscopic papillectomy: indications, techniques, and results.
De Palma GD
World J Gastroenterol 2014 Feb 14;20(6):1537-43. doi: 10.3748/wjg.v20.i6.1537. PMID: 24587629Free PMC Article
Secretin-enhanced MR cholangiopancreatography: spectrum of findings.
Tirkes T, Sandrasegaran K, Sanyal R, Sherman S, Schmidt CM, Cote GA, Akisik F
Radiographics 2013 Nov-Dec;33(7):1889-906. doi: 10.1148/rg.337125014. PMID: 24224585
ERCP.
Cotton PB
Gut 1977 Apr;18(4):316-41. doi: 10.1136/gut.18.4.316. PMID: 324875Free PMC Article

Prognosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
The World Health Organization Reporting System for Pancreaticobiliary Cytopathology.
Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Intraductal papillary neoplasm of the bile duct - A comprehensive review.
Krawczyk M, Ziarkiewicz-Wróblewska B, Podgórska J, Grzybowski J, Gierej B, Krawczyk P, Grąt M, Kornasiewicz O, Skalski M, Wróblewski T
Adv Med Sci 2021 Mar;66(1):138-147. Epub 2021 Feb 6 doi: 10.1016/j.advms.2021.01.005. PMID: 33556909
Intraductal papillary neoplasm of the bile duct.
Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576Free PMC Article

Clinical prediction guides

Development of intraductal papillary neoplasm of the bile duct in patients with occupational cholangiocarcinoma.
Kubo S, Tanaka S, Kinoshita M, Shinkawa H, Ishizawa T, Sato Y
Virchows Arch 2023 Apr;482(4):745-753. Epub 2023 Jan 30 doi: 10.1007/s00428-023-03499-5. PMID: 36715769
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
"Biliary Diseases with Pancreatic Counterparts": Cross-sectional Imaging Findings.
Katabathina VS, Flaherty EM, Dasyam AK, Menias CO, Riddle ND, Lath N, Kozaka K, Matsui O, Nakanuma Y, Prasad SR
Radiographics 2016 Mar-Apr;36(2):374-92. Epub 2016 Feb 1 doi: 10.1148/rg.2016150071. PMID: 26824512
Intraductal papillary neoplasm of the bile duct.
Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576Free PMC Article
Imaging bile duct tumors: pathologic concepts, classification, and early tumor detection.
Joo I, Lee JM
Abdom Imaging 2013 Dec;38(6):1334-50. doi: 10.1007/s00261-013-0027-3. PMID: 23925840

Recent systematic reviews

Pancreatic ductal adenocarcinomas associated with intraductal papillary mucinous neoplasms (IPMNs) versus pseudo-IPMNs: relative frequency, clinicopathologic characteristics and differential diagnosis.
Muraki T, Jang KT, Reid MD, Pehlivanoglu B, Memis B, Basturk O, Mittal P, Kooby D, Maithel SK, Sarmiento JM, Christians K, Tsai S, Evans D, Adsay V
Mod Pathol 2022 Jan;35(1):96-105. Epub 2021 Sep 13 doi: 10.1038/s41379-021-00902-x. PMID: 34518632
Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Systematic Review and Meta-analysis of Current Experience in Treating IPNB: Clinical and Pathological Correlates.
Gordon-Weeks AN, Jones K, Harriss E, Smith A, Silva M
Ann Surg 2016 Apr;263(4):656-63. doi: 10.1097/SLA.0000000000001426. PMID: 26501712
Current therapy of hilar cholangiocarcinoma.
Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465
Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature.
Liszka L, Pajak J, Zielińska-Pajak E, Krzych L, Gołka D, Mrowiec S, Lampe P
J Hepatobiliary Pancreat Sci 2010 May;17(3):246-61. Epub 2010 Mar 4 doi: 10.1007/s00534-010-0268-2. PMID: 20464560

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