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Alzheimer disease 5

MedGen UID:
356103
Concept ID:
C1865868
Disease or Syndrome
Synonym: ALZHEIMER DISEASE, FAMILIAL, 5
 
Monarch Initiative: MONDO:0011194
OMIM®: 602096

Authors:
Thomas D Bird   view full author information

Clinical features

From HPO
Alzheimer disease
MedGen UID:
1853
Concept ID:
C0002395
Disease or Syndrome
Alzheimer's disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.\n\nMemory loss is the most common sign of Alzheimer's disease. Forgetfulness may be subtle at first, but the loss of memory worsens over time until it interferes with most aspects of daily living. Even in familiar settings, a person with Alzheimer's disease may get lost or become confused. Routine tasks such as preparing meals, doing laundry, and performing other household chores can be challenging. Additionally, it may become difficult to recognize people and name objects. Affected people increasingly require help with dressing, eating, and personal care.\n\nAs the disorder progresses, some people with Alzheimer's disease experience personality and behavioral changes and have trouble interacting in a socially appropriate manner. Other common symptoms include agitation, restlessness, withdrawal, and loss of language skills. People with Alzheimer's disease usually require total care during the advanced stages of the disease.\n\nIndividuals with Alzheimer's disease usually survive 8 to 10 years after the appearance of symptoms, but the course of the disease can range from 1 to 25 years. Survival is usually shorter in individuals diagnosed after age 80 than in those diagnosed at a younger age. In Alzheimer's disease, death usually results from pneumonia, malnutrition, or general body wasting (inanition).\n\nAlzheimer's disease can be classified as early-onset or late-onset. The signs and symptoms of the early-onset form appear between a person's thirties and mid-sixties, while the late-onset form appears during or after a person's mid-sixties. The early-onset form of Alzheimer's disease is much less common than the late-onset form, accounting for less than 10 percent of all cases of Alzheimer's disease.

Recent clinical studies

Etiology

Brendel M, Barthel H, van Eimeren T, Marek K, Beyer L, Song M, Palleis C, Gehmeyr M, Fietzek U, Respondek G, Sauerbeck J, Nitschmann A, Zach C, Hammes J, Barbe MT, Onur O, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens A, Roeber S, Herms J, Bötzel K, Classen J, Bartenstein P, Villemagne V, Levin J, Höglinger GU, Drzezga A, Seibyl J, Sabri O
JAMA Neurol 2020 Nov 1;77(11):1408-1419. doi: 10.1001/jamaneurol.2020.2526. PMID: 33165511Free PMC Article
Garibotto V, Montandon ML, Viaud CT, Allaoua M, Assal F, Burkhard PR, Ratib O, Zaidi H
Clin Nucl Med 2013 Mar;38(3):e112-7. doi: 10.1097/RLU.0b013e318279b991. PMID: 23357822
Rogers MA, Langa KM
Am J Epidemiol 2010 Mar 15;171(6):728-35. Epub 2010 Feb 11 doi: 10.1093/aje/kwp453. PMID: 20150357Free PMC Article
Halliday GM, Shepherd CE, McCann H, Reid WG, Grayson DA, Broe GA, Kril JJ
Arch Neurol 2000 Jun;57(6):831-6. doi: 10.1001/archneur.57.6.831. PMID: 10867780
Chu CT, Gray L, Goldstein LB, Hulette CM
J Neuropathol Exp Neurol 1998 Jan;57(1):30-8. doi: 10.1097/00005072-199801000-00005. PMID: 9600195

Diagnosis

Brendel M, Barthel H, van Eimeren T, Marek K, Beyer L, Song M, Palleis C, Gehmeyr M, Fietzek U, Respondek G, Sauerbeck J, Nitschmann A, Zach C, Hammes J, Barbe MT, Onur O, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens A, Roeber S, Herms J, Bötzel K, Classen J, Bartenstein P, Villemagne V, Levin J, Höglinger GU, Drzezga A, Seibyl J, Sabri O
JAMA Neurol 2020 Nov 1;77(11):1408-1419. doi: 10.1001/jamaneurol.2020.2526. PMID: 33165511Free PMC Article
Garibotto V, Montandon ML, Viaud CT, Allaoua M, Assal F, Burkhard PR, Ratib O, Zaidi H
Clin Nucl Med 2013 Mar;38(3):e112-7. doi: 10.1097/RLU.0b013e318279b991. PMID: 23357822
Rogers MA, Langa KM
Am J Epidemiol 2010 Mar 15;171(6):728-35. Epub 2010 Feb 11 doi: 10.1093/aje/kwp453. PMID: 20150357Free PMC Article
Halliday GM, Shepherd CE, McCann H, Reid WG, Grayson DA, Broe GA, Kril JJ
Arch Neurol 2000 Jun;57(6):831-6. doi: 10.1001/archneur.57.6.831. PMID: 10867780
Chu CT, Gray L, Goldstein LB, Hulette CM
J Neuropathol Exp Neurol 1998 Jan;57(1):30-8. doi: 10.1097/00005072-199801000-00005. PMID: 9600195

Therapy

Shin SJ, Jeong YO, Jeon SG, Kim S, Lee SK, Nam Y, Park YH, Kim D, Lee YS, Choi HS, Kim JI, Kim JJ, Moon M
Int J Mol Sci 2018 Dec 13;19(12) doi: 10.3390/ijms19124026. PMID: 30551564Free PMC Article
Halliday GM, Shepherd CE, McCann H, Reid WG, Grayson DA, Broe GA, Kril JJ
Arch Neurol 2000 Jun;57(6):831-6. doi: 10.1001/archneur.57.6.831. PMID: 10867780

Prognosis

Garibotto V, Montandon ML, Viaud CT, Allaoua M, Assal F, Burkhard PR, Ratib O, Zaidi H
Clin Nucl Med 2013 Mar;38(3):e112-7. doi: 10.1097/RLU.0b013e318279b991. PMID: 23357822
Chu CT, Gray L, Goldstein LB, Hulette CM
J Neuropathol Exp Neurol 1998 Jan;57(1):30-8. doi: 10.1097/00005072-199801000-00005. PMID: 9600195

Clinical prediction guides

Brendel M, Barthel H, van Eimeren T, Marek K, Beyer L, Song M, Palleis C, Gehmeyr M, Fietzek U, Respondek G, Sauerbeck J, Nitschmann A, Zach C, Hammes J, Barbe MT, Onur O, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens A, Roeber S, Herms J, Bötzel K, Classen J, Bartenstein P, Villemagne V, Levin J, Höglinger GU, Drzezga A, Seibyl J, Sabri O
JAMA Neurol 2020 Nov 1;77(11):1408-1419. doi: 10.1001/jamaneurol.2020.2526. PMID: 33165511Free PMC Article
Halliday GM, Shepherd CE, McCann H, Reid WG, Grayson DA, Broe GA, Kril JJ
Arch Neurol 2000 Jun;57(6):831-6. doi: 10.1001/archneur.57.6.831. PMID: 10867780
Chu CT, Gray L, Goldstein LB, Hulette CM
J Neuropathol Exp Neurol 1998 Jan;57(1):30-8. doi: 10.1097/00005072-199801000-00005. PMID: 9600195

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