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Cerebellar degeneration-related autoantigen-3(CDR3)

MedGen UID:
355548
•Concept ID:
C1865782
•
Finding
Synonym: CDR3
 
Cytogenetic location: 17q25
 
OMIM®: 602197

Clinical features

From HPO
Abnormal cerebellum morphology
MedGen UID:
400925
•Concept ID:
C1866129
•
Anatomical Abnormality
Any structural abnormality of the cerebellum.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Changes in genotype and fluconazole susceptibility of isolates from patients with Candida glabrata in Tunisia.
Abbes S, Amouri I, Sellami H, Neji S, Trabelsi H, Cheikhrouhou F, Makni F, Ranque S, Ayadi A
Therapie 2014 Sep-Oct;69(5):449-55. Epub 2014 Oct 7 doi: 10.2515/therapie/2014059. PMID: 25285365

Recent clinical studies

Etiology

Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.
Yang H, Chen J, Liu S, Xue Y, Li Z, Wang T, Jiao L, An Q, Liu B, Wang J, Zhao H
Arterioscler Thromb Vasc Biol 2024 Mar;44(3):e99-e115. Epub 2024 Jan 18 doi: 10.1161/ATVBAHA.123.319756. PMID: 38235556
CDR2 and CDR2L line blot performance in PCA-1/anti-Yo paraneoplastic autoimmunity.
Vorasoot N, Scharf M, Miske R, Thakolwiboon S, Dubey D, Mills JR, Pittock SJ, Zekeridou A, Ott A, McKeon A
Front Immunol 2023;14:1265797. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1265797. PMID: 37841252Free PMC Article
CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.
Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
Eur J Pharmacol 2022 May 5;922:174915. Epub 2022 Mar 24 doi: 10.1016/j.ejphar.2022.174915. PMID: 35339477
Paraneoplastic Cerebellar Degeneration: The Importance of Including CDR2L as a Diagnostic Marker.
Herdlevær I, Haugen M, Mazengia K, Totland C, Vedeler C
Neurol Neuroimmunol Neuroinflamm 2021 Mar;8(2) Epub 2021 Feb 2 doi: 10.1212/NXI.0000000000000963. PMID: 33531379Free PMC Article
Mutation screening in Rett syndrome patients.
Xiang F, Buervenich S, Nicolao P, Bailey ME, Zhang Z, Anvret M
J Med Genet 2000 Apr;37(4):250-5. doi: 10.1136/jmg.37.4.250. PMID: 10745042Free PMC Article

Diagnosis

Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.
Yang H, Chen J, Liu S, Xue Y, Li Z, Wang T, Jiao L, An Q, Liu B, Wang J, Zhao H
Arterioscler Thromb Vasc Biol 2024 Mar;44(3):e99-e115. Epub 2024 Jan 18 doi: 10.1161/ATVBAHA.123.319756. PMID: 38235556
CDR2 and CDR2L line blot performance in PCA-1/anti-Yo paraneoplastic autoimmunity.
Vorasoot N, Scharf M, Miske R, Thakolwiboon S, Dubey D, Mills JR, Pittock SJ, Zekeridou A, Ott A, McKeon A
Front Immunol 2023;14:1265797. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1265797. PMID: 37841252Free PMC Article
A cerebellar degeneration-related protein 2-like cell-based assay for anti-Yo detection in patients with paraneoplastic cerebellar degeneration.
Erikstad KI, Herdlevaer I, Peter E, Haugen M, Totland C, Vedeler C
Eur J Neurol 2023 Jun;30(6):1727-1733. Epub 2023 Mar 26 doi: 10.1111/ene.15786. PMID: 36912432
Paraneoplastic Cerebellar Degeneration: The Importance of Including CDR2L as a Diagnostic Marker.
Herdlevær I, Haugen M, Mazengia K, Totland C, Vedeler C
Neurol Neuroimmunol Neuroinflamm 2021 Mar;8(2) Epub 2021 Feb 2 doi: 10.1212/NXI.0000000000000963. PMID: 33531379Free PMC Article
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Panja D, Vedeler CA, Schubert M
Neuropathol Appl Neurobiol 2019 Feb;45(2):141-156. Epub 2018 May 24 doi: 10.1111/nan.12492. PMID: 29679372Free PMC Article

Therapy

A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking.
Harrison EB, Porrello A, Bowman BM, Belanger AR, Yacovone G, Azam SH, Windham IA, Ghosh SK, Wang M, Mckenzie N, Waugh TA, Van Swearingen AED, Cohen SM, Allen DG, Goodwin TJ, Mascenik T, Bear JE, Cohen S, Randell SH, Massion PP, Major MB, Huang L, Pecot CV
Cancer Res 2020 Nov 15;80(22):4972-4985. Epub 2020 Sep 25 doi: 10.1158/0008-5472.CAN-20-1162. PMID: 32978168Free PMC Article
Changes in genotype and fluconazole susceptibility of isolates from patients with Candida glabrata in Tunisia.
Abbes S, Amouri I, Sellami H, Neji S, Trabelsi H, Cheikhrouhou F, Makni F, Ranque S, Ayadi A
Therapie 2014 Sep-Oct;69(5):449-55. Epub 2014 Oct 7 doi: 10.2515/therapie/2014059. PMID: 25285365

Prognosis

CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.
Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
Eur J Pharmacol 2022 May 5;922:174915. Epub 2022 Mar 24 doi: 10.1016/j.ejphar.2022.174915. PMID: 35339477
A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking.
Harrison EB, Porrello A, Bowman BM, Belanger AR, Yacovone G, Azam SH, Windham IA, Ghosh SK, Wang M, Mckenzie N, Waugh TA, Van Swearingen AED, Cohen SM, Allen DG, Goodwin TJ, Mascenik T, Bear JE, Cohen S, Randell SH, Massion PP, Major MB, Huang L, Pecot CV
Cancer Res 2020 Nov 15;80(22):4972-4985. Epub 2020 Sep 25 doi: 10.1158/0008-5472.CAN-20-1162. PMID: 32978168Free PMC Article
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E
Cancer Cell 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. PMID: 31935372Free PMC Article
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.
Jarius S, Wildemann B
J Neuroinflammation 2015 Sep 17;12:168. doi: 10.1186/s12974-015-0358-9. PMID: 26377319Free PMC Article
'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII.
Jarius S, Wildemann B
J Neuroinflammation 2015 Sep 17;12:166. doi: 10.1186/s12974-015-0356-y. PMID: 26377085Free PMC Article

Clinical prediction guides

A cerebellar degeneration-related protein 2-like cell-based assay for anti-Yo detection in patients with paraneoplastic cerebellar degeneration.
Erikstad KI, Herdlevaer I, Peter E, Haugen M, Totland C, Vedeler C
Eur J Neurol 2023 Jun;30(6):1727-1733. Epub 2023 Mar 26 doi: 10.1111/ene.15786. PMID: 36912432
CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.
Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
Eur J Pharmacol 2022 May 5;922:174915. Epub 2022 Mar 24 doi: 10.1016/j.ejphar.2022.174915. PMID: 35339477
Expression of cerebellar degeneration-related proteins CDR2 and CDR2L in human and rat brain tissue.
Raspotnig M, Kråkenes T, Herdlevær I, Haugen M, Vedeler C
J Neuroimmunol 2022 Jan 15;362:577766. Epub 2021 Nov 11 doi: 10.1016/j.jneuroim.2021.577766. PMID: 34823119
Paraneoplastic Cerebellar Degeneration: The Importance of Including CDR2L as a Diagnostic Marker.
Herdlevær I, Haugen M, Mazengia K, Totland C, Vedeler C
Neurol Neuroimmunol Neuroinflamm 2021 Mar;8(2) Epub 2021 Feb 2 doi: 10.1212/NXI.0000000000000963. PMID: 33531379Free PMC Article
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E
Cancer Cell 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. PMID: 31935372Free PMC Article

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