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Thyroid carcinoma, nonmedullary, with or without cell oxyphilia

MedGen UID:
400409
•Concept ID:
C1863925
•
Neoplastic Process
Synonym: TCO 1
 
Monarch Initiative: MONDO:0011312
OMIM®: 603386

Definition

The familial form of nonmedullary thyroid carcinoma (NMTC) is a complex genetic disorder characterized by multifocal neoplasia and a higher degree of aggressiveness than its sporadic counterpart. One peculiar form of thyroid tumors is characterized by the presence of cell oxyphilia. Oxophil cells are found in a minority of thyroid tumors, either benign or malignant. These cells show a large volume of granular eosinophilic cytoplasm and are very rich in mitochondria. The familial occurrence of thyroid tumors with cell oxyphilia was reported by Katoh et al. (1998). Canzian et al. (1998) reported such a family with affected members in 3 generations and by linkage analysis mapped the gene to 19p13. For general phenotypic information and a discussion of genetic heterogeneity of NMTC, see 188550. [from OMIM]

Professional guidelines

PubMed

Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2022 Mar 30;132(3) Epub 2022 Mar 3 doi: 10.20452/pamw.16222. PMID: 35243857Free PMC Article
Papillary microcarcinoma-Management issues.
Shaha AR, Tuttle RM
Indian J Cancer 2021 Apr-Jun;58(2):155-157. doi: 10.4103/ijc.IJC_281_21. PMID: 34100408
Contemporary Thyroid Nodule Evaluation and Management.
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article

Recent clinical studies

Etiology

A Nod to the Nodes: An Overview of the Role of Central Neck Dissection in the Management of Papillary Thyroid Carcinoma.
Mechera R, Maréchal-Ross I, Sidhu SB, Campbell P, Sywak MS
Surg Oncol Clin N Am 2023 Apr;32(2):383-398. doi: 10.1016/j.soc.2022.10.012. PMID: 36925192
Radioactive Iodine for Papillary Thyroid Carcinoma.
Chan WWL, Kwong DLW
Methods Mol Biol 2022;2534:225-241. doi: 10.1007/978-1-0716-2505-7_16. PMID: 35670979
Predicting nodal metastases in papillary thyroid carcinoma using artificial intelligence.
Esce AR, Redemann JP, Sanchez AC, Olson GT, Hanson JA, Agarwal S, Boyd NH, Martin DR
Am J Surg 2021 Nov;222(5):952-958. Epub 2021 May 13 doi: 10.1016/j.amjsurg.2021.05.002. PMID: 34030870
Is Less More? Adoption of Treatment Guidelines for Low-Risk Papillary Thyroid Cancer.
Beninato T, Laird AM
Ann Surg Oncol 2021 Jul;28(7):3461-3462. Epub 2021 Apr 15 doi: 10.1245/s10434-021-09996-8. PMID: 33860359
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998

Diagnosis

Cytology of mucoepidermoid carcinoma of thyroid.
Purkait S, Sethy M, Parida PK, Mitra S
Cytopathology 2021 Nov;32(6):836-839. Epub 2021 Jun 24 doi: 10.1111/cyt.13018. PMID: 34086373
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Cribriform-morular variant of thyroid carcinoma.
Cameselle-Teijeiro JM, Sobrinho-Simões M
Pathologica 2019 Mar;111(1):1-3. doi: 10.32074/1591-951X-66-18. PMID: 31217615Free PMC Article
Black Thyroid.
Yu NY, Gamez ME
Int J Surg Pathol 2019 Jun;27(4):401-402. Epub 2018 Sep 17 doi: 10.1177/1066896918800773. PMID: 30322317

Therapy

Radioactive Iodine for Papillary Thyroid Carcinoma.
Chan WWL, Kwong DLW
Methods Mol Biol 2022;2534:225-241. doi: 10.1007/978-1-0716-2505-7_16. PMID: 35670979
Pralsetinib: First Approval.
Markham A
Drugs 2020 Nov;80(17):1865-1870. doi: 10.1007/s40265-020-01427-4. PMID: 33136236
Black Thyroid.
Yu NY, Gamez ME
Int J Surg Pathol 2019 Jun;27(4):401-402. Epub 2018 Sep 17 doi: 10.1177/1066896918800773. PMID: 30322317
30 years of the Chernobyl accident. Molecular genetic mechanisms of carcinogenesis of thyroid gland.
Tronko ND, Pushkarev VM
Tsitol Genet 2016 Nov-Dec;50(6):15-22. PMID: 30484597
Chornobyl thirty years later: evaluation of the consequence by biologists and medics Experience of thyroid gland status screening in postchernobyl period.
Blume YB, Grodzinsky DM
Tsitol Genet 2016 Nov-Dec;50(6):3-7. PMID: 30484595

Prognosis

Radioactive Iodine for Papillary Thyroid Carcinoma.
Chan WWL, Kwong DLW
Methods Mol Biol 2022;2534:225-241. doi: 10.1007/978-1-0716-2505-7_16. PMID: 35670979
Thyroid Cancer Incidence and Mortality Trends in the United States: 2000-2018.
Megwalu UC, Moon PK
Thyroid 2022 May;32(5):560-570. Epub 2022 Mar 15 doi: 10.1089/thy.2021.0662. PMID: 35132899
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Risk factors for local recurrence following lateral neck dissection for papillary thyroid carcinoma.
Raffaelli M, De Crea C, Sessa L, Tempera SE, Belluzzi A, Lombardi CP, Bellantone R
Endocrine 2019 Feb;63(2):310-315. Epub 2018 Oct 19 doi: 10.1007/s12020-018-1788-9. PMID: 30341706

Clinical prediction guides

Extranodal Extension Is an Independent Prognostic Factor in Papillary Thyroid Cancer: A Propensity Score Matching Analysis.
Zhou TH, Lin B, Wu F, Lu KN, Mao LL, Zhao LQ, Jiang KC, Zhang Y, Zheng WJ, Luo DC
Front Endocrinol (Lausanne) 2021;12:759049. Epub 2021 Nov 3 doi: 10.3389/fendo.2021.759049. PMID: 34803921Free PMC Article
Predicting nodal metastases in papillary thyroid carcinoma using artificial intelligence.
Esce AR, Redemann JP, Sanchez AC, Olson GT, Hanson JA, Agarwal S, Boyd NH, Martin DR
Am J Surg 2021 Nov;222(5):952-958. Epub 2021 May 13 doi: 10.1016/j.amjsurg.2021.05.002. PMID: 34030870
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.
Ibrahimpasic T, Ghossein R, Shah JP, Ganly I
Thyroid 2019 Mar;29(3):311-321. doi: 10.1089/thy.2018.0509. PMID: 30747050Free PMC Article
Persistent ST-Segment Elevation: A Pandora's Box.
Viscuse PV, Foley TA, Michelena HI
Circulation 2018 Sep 11;138(11):1166-1168. doi: 10.1161/CIRCULATIONAHA.118.036584. PMID: 30354381

Recent systematic reviews

Efficacy and safety of ultrasound-guided radiofrequency, microwave and laser ablation for the treatment of T1N0M0 papillary thyroid carcinoma on a large scale: a systematic review and meta-analysis.
Gao X, Yang Y, Wang Y, Huang Y
Int J Hyperthermia 2023 Dec;40(1):2244713. doi: 10.1080/02656736.2023.2244713. PMID: 37604507
Risk and Prognostic Factors for BRAF(V600E) Mutations in Papillary Thyroid Carcinoma.
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Active Surveillance Versus Thyroid Surgery for Differentiated Thyroid Cancer: A Systematic Review.
Chou R, Dana T, Haymart M, Leung AM, Tufano RP, Sosa JA, Ringel MD
Thyroid 2022 Apr;32(4):351-367. Epub 2022 Mar 17 doi: 10.1089/thy.2021.0539. PMID: 35081743Free PMC Article
Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
Differentiated Thyroid Cancer-Treatment: State of the Art.
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article

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