Caudal interpedicular narrowing

MedGen UID:: 350247
•Concept ID:: C1863734
•: Finding

Synonym:	Caudal narrowing of interpedicular distances

HPO:	HP:0008457

Definition

Narrowing (becoming gradually narrower) of the distance between vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column. Note that normally, the interpedicular distances get progressively wider as one proceeds down the spine. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCaudal interpedicular narrowing

Abnormal axial skeleton morphology
- Abnormality of the vertebral column
  - Abnormal vertebral morphology
    - Abnormal form of the vertebral bodies
      - Vertebral arch anomaly
        Narrow vertebral interpedicular distance
        Caudal interpedicular narrowing
        Lumbar interpedicular narrowing

Conditions with this feature

Spondyloepimetaphyseal dysplasia with multiple dislocations

MedGen UID:: 350960
•Concept ID:: C1863732
•: Disease or Syndrome

Spondyloepimetaphyseal dysplasia with joint laxity type 2 (SEMDJL2) is characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly (summary by Min et al., 2011). For a discussion of genetic heterogeneity of SEMD with joint laxity, see SEMDJL1 (271640).

See: Condition Record

Spondyloepimetaphyseal dysplasia with multiple dislocations

Professional guidelines

PubMed

Skeletal development of achondroplasia: analysis of genotyped patients.

Matsui Y, Kawabata H, Ozono K, Yasui N
Pediatr Int 2001 Aug;43(4):361-3. doi: 10.1046/j.1442-200x.2001.01416.x. PMID: 11472579

See all (1)

Recent clinical studies

Etiology

Radiographic assessment of lumbar facet distance spacing and pediatric spondylolysis.

Zehnder SW, Ward CV, Crow AJ, Alander D, Latimer B
Spine (Phila Pa 1976) 2009 Feb 1;34(3):285-90. doi: 10.1097/BRS.0b013e3181956053. PMID: 19179924

Abnormalities of the axial and proximal appendicular skeleton in adults with Laron syndrome (growth hormone insensitivity).

Kornreich L, Konen O, Schwarz M, Siegel Y, Horev G, Hershkovitz I, Laron Z
Skeletal Radiol 2008 Feb;37(2):153-60. Epub 2007 Nov 9 doi: 10.1007/s00256-007-0402-7. PMID: 17992526

See all (2)

Diagnosis

Abnormalities of the axial and proximal appendicular skeleton in adults with Laron syndrome (growth hormone insensitivity).

Kornreich L, Konen O, Schwarz M, Siegel Y, Horev G, Hershkovitz I, Laron Z
Skeletal Radiol 2008 Feb;37(2):153-60. Epub 2007 Nov 9 doi: 10.1007/s00256-007-0402-7. PMID: 17992526

Skeletal development of achondroplasia: analysis of genotyped patients.

Matsui Y, Kawabata H, Ozono K, Yasui N
Pediatr Int 2001 Aug;43(4):361-3. doi: 10.1046/j.1442-200x.2001.01416.x. PMID: 11472579

See all (2)