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Multiple palmar creases

MedGen UID:
354610
Concept ID:
C1861872
Finding
Synonym: Multiple palm lines
 
HPO: HP:0006114

Definition

The presence of multiple creases on the palm of the hand (more than the normal three major creases (distal transverse crease, proximal transverse crease, and thenar crease). [from HPO]

Term Hierarchy

Conditions with this feature

Chromosome 3q29 microduplication syndrome
MedGen UID:
440897
Concept ID:
C2749873
Disease or Syndrome
3q29 microduplication syndrome (also known as 3q29 duplication syndrome) is a condition that results from the copying (duplication) of a small piece of chromosome 3 in each cell. The duplication occurs on the long (q) arm of the chromosome at a position designated q29.\n\nThe features associated with 3q29 microduplication syndrome vary widely. Some individuals with this chromosomal change have very mild or no related signs and symptoms, and the duplication is discovered because they undergo genetic testing only after a family member is diagnosed. Other people with a 3q29 microduplication have delayed development (particularly speech delay) and intellectual disability or learning difficulties. Although most affected individuals have no major birth defects, eye abnormalities, heart defects, and an unusually small head (microcephaly) can occur. 3q29 microduplication syndrome may increase the likelihood of being overweight or having obesity, although it is hard to determine whether these weight issues are caused by the duplication.

Professional guidelines

PubMed

Chatron N, Haddad V, Andrieux J, Désir J, Boute O, Dieux A, Baumann C, Drunat S, Gérard M, Bonnet C, Leheup B, Till M, Rossi M, Flori E, Alembik Y, Stewart H, McParland J, Bernardini L, Castelluccio P, Roos L, Tümer Z, Fagan K, Hackett A, Bain N, van Haeringen A, Ruivenkamp C, Benzacken B, Sanlaville D, Edery P, Aboura A, Schluth-Bolard C
Am J Med Genet A 2015 May;167A(5):1008-17. Epub 2015 Feb 25 doi: 10.1002/ajmg.a.36856. PMID: 25728055
Lumenta DB, Kitzinger HB, Beck H, Frey M
J Hand Surg Am 2010 Aug;35(8):1323-9. Epub 2010 Jul 16 doi: 10.1016/j.jhsa.2010.04.033. PMID: 20638200

Recent clinical studies

Etiology

Kaya G, Alavanda C
Skin Res Technol 2024 Oct;30(10):e70077. doi: 10.1111/srt.70077. PMID: 39373295Free PMC Article
Özkan S, Teunis T, Ring DC, Chen NC
Clin Orthop Relat Res 2019 Oct;477(10):2278-2286. doi: 10.1097/CORR.0000000000000807. PMID: 32142501Free PMC Article
McPherson E, Cold C
Am J Med Genet A 2016 Jan;170A(1):52-9. Epub 2015 Sep 16 doi: 10.1002/ajmg.a.37386. PMID: 26373818
Lumenta DB, Kitzinger HB, Beck H, Frey M
J Hand Surg Am 2010 Aug;35(8):1323-9. Epub 2010 Jul 16 doi: 10.1016/j.jhsa.2010.04.033. PMID: 20638200
Antevy PM, Zuckerbraun NS, Saladino RA, Pitetti RD
Pediatr Emerg Care 2010 Mar;26(3):177-80. doi: 10.1097/PEC.0b013e3181d1dfaf. PMID: 20179662

Diagnosis

Saraswat N, Tripathy DM, Kumar S
JAMA Dermatol 2022 Dec 1;158(12):1439. doi: 10.1001/jamadermatol.2022.4442. PMID: 36287580
Fölster-Holst R, Rohrer T, Jung AM
J Dtsch Dermatol Ges 2018 Oct;16(10):1289-1295. doi: 10.1111/ddg.13665. PMID: 30300491
Salo-Mullen EE, Lynn PB, Wang L, Walsh M, Gopalan A, Shia J, Tran C, Man FY, McBride S, Schattner M, Zhang L, Weiser MR, Stadler ZK
Fam Cancer 2018 Jan;17(1):71-77. doi: 10.1007/s10689-017-0006-x. PMID: 28555354Free PMC Article
Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. PMID: 27900361Free PMC Article
Madhukara J, Kumaran MS
Indian J Dermatol Venereol Leprol 2007 Nov-Dec;73(6):406-8. doi: 10.4103/0378-6323.37059. PMID: 18032860

Therapy

Özkan S, Teunis T, Ring DC, Chen NC
Clin Orthop Relat Res 2019 Oct;477(10):2278-2286. doi: 10.1097/CORR.0000000000000807. PMID: 32142501Free PMC Article
Antevy PM, Zuckerbraun NS, Saladino RA, Pitetti RD
Pediatr Emerg Care 2010 Mar;26(3):177-80. doi: 10.1097/PEC.0b013e3181d1dfaf. PMID: 20179662
Misselwitz B, Goede JS, Pestalozzi BC, Schanz U, Seebach JD
Ann Hematol 2010 Jun;89(6):569-77. Epub 2009 Nov 17 doi: 10.1007/s00277-009-0849-9. PMID: 19921193
Autti-Rämö I, Fagerlund A, Ervalahti N, Loimu L, Korkman M, Hoyme HE
Am J Med Genet A 2006 Jan 15;140(2):137-43. doi: 10.1002/ajmg.a.31037. PMID: 16353236
Burnside NJ, Alberta L, Robinson-Bostom L, Bostom A
J Am Acad Dermatol 2005 Nov;53(5 Suppl 1):S281-4. doi: 10.1016/j.jaad.2005.04.009. PMID: 16227109

Prognosis

Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. PMID: 27900361Free PMC Article
McPherson E, Cold C
Am J Med Genet A 2016 Jan;170A(1):52-9. Epub 2015 Sep 16 doi: 10.1002/ajmg.a.37386. PMID: 26373818
Basaran SY, Sensoy V, Kiroglu K, Messiaen L, Tuysuz B
Genet Couns 2010;21(3):307-16. PMID: 20964122
Pollono D, Drut R, Cecotti N, Pollono A
Fetal Pediatr Pathol 2009;28(4):185-91. doi: 10.1080/15513810902984129. PMID: 19842870
Gourion D, Goldberger C, Bourdel MC, Jean Bayle F, Lôo H, Krebs MO
Psychiatry Res 2004 Jan 30;125(1):21-8. doi: 10.1016/j.psychres.2003.06.001. PMID: 14967549

Clinical prediction guides

Minatogawa M, Unzaki A, Morisaki H, Syx D, Sonoda T, Janecke AR, Slavotinek A, Voermans NC, Lacassie Y, Mendoza-Londono R, Wierenga KJ, Jayakar P, Gahl WA, Tifft CJ, Figuera LE, Hilhorst-Hofstee Y, Maugeri A, Ishikawa K, Kobayashi T, Aoki Y, Ohura T, Kawame H, Kono M, Mochida K, Tokorodani C, Kikkawa K, Morisaki T, Kobayashi T, Nakane T, Kubo A, Ranells JD, Migita O, Sobey G, Kaur A, Ishikawa M, Yamaguchi T, Matsumoto N, Malfait F, Miyake N, Kosho T
J Med Genet 2022 Sep;59(9):865-877. Epub 2021 Nov 23 doi: 10.1136/jmedgenet-2020-107623. PMID: 34815299Free PMC Article
Özkan S, Teunis T, Ring DC, Chen NC
Clin Orthop Relat Res 2019 Oct;477(10):2278-2286. doi: 10.1097/CORR.0000000000000807. PMID: 32142501Free PMC Article
Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, Wang L, Fan Y, Gu X, Yu Y
Am J Med Genet A 2017 Feb;173(2):510-514. Epub 2016 Oct 19 doi: 10.1002/ajmg.a.38025. PMID: 27759909
Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. PMID: 27900361Free PMC Article
Wijerathne BT, Meier RJ, Agampodi SB
J Med Case Rep 2016 Sep 20;10(1):258. doi: 10.1186/s13256-016-1048-7. PMID: 27650795Free PMC Article

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