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Colchicine resistance(CLCS)

MedGen UID:
396151
•Concept ID:
C1861502
•
Disease or Syndrome
Synonym: COLCHICINE SENSITIVITY
Drug:
colchicine
MedGen UID:
3148
•Concept ID:
C0009262
•
Pharmacologic Substance
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. [from NCI]
colchicine
 
Gene (location): ABCB1 (7q21.12)
 
OMIM®: 120080

Professional guidelines

PubMed

French protocol for the diagnosis and management of familial Mediterranean fever.
Georgin-Lavialle S, Savey L, Cuisset L, Boursier G, Boffa JJ, Delplanque M, Bourguiba R, Monfort JB, Touitou I, Grateau G; Collaborators, Kone-Paut I, Hentgen V
Rev Med Interne 2023 Nov;44(11):602-616. Epub 2023 Oct 29 doi: 10.1016/j.revmed.2023.10.441. PMID: 37903671
Treat-to-target strategies for the management of familial Mediterranean Fever in children.
Ehlers L, Rolfes E, Lieber M, Müller D, Lainka E, Gohar F, Klaus G, Girschick H, Hörstermann J, Kümmerle-Deschner J, Brunner J, Palm-Beden K, Tenbrock K, von Wrangel L, Faßhauer M, Blank N, Trauzeddel R, von Stuckrad ASL, Higgins S, Welzel T, Lutz T, Hentgen V, Foell D, Wittkowski H, Kallinich T
Pediatr Rheumatol Online J 2023 Sep 26;21(1):108. doi: 10.1186/s12969-023-00875-y. PMID: 37752496Free PMC Article
A survey of resistance to colchicine treatment for French patients with familial Mediterranean fever.
Corsia A, Georgin-Lavialle S, Hentgen V, Hachulla E, Grateau G, Faye A, Quartier P, Rossi-Semerano L, Koné-Paut I
Orphanet J Rare Dis 2017 Mar 16;12(1):54. doi: 10.1186/s13023-017-0609-1. PMID: 28302131Free PMC Article

Recent clinical studies

Etiology

Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis.
Collini V, Andreis A, De Biasio M, De Martino M, Isola M, Croatto N, Lepre V, Cantarini L, Merlo M, Sinagra G, Abbate A, Lazaros G, Brucato A, Klein AL, Imazio M
Open Heart 2024 Mar 15;11(1) doi: 10.1136/openhrt-2023-002599. PMID: 38490715Free PMC Article
Emerging Therapies for Recurrent Pericarditis: Interleukin-1 inhibitors.
Lo Presti S, Elajami TK, Reyaldeen R, Anthony C, Imazio M, Klein AL
J Am Heart Assoc 2021 Oct 5;10(19):e021685. Epub 2021 Sep 25 doi: 10.1161/JAHA.121.021685. PMID: 34569270Free PMC Article
Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments.
Ozen S, Kone-Paut I, Gül A
Semin Arthritis Rheum 2017 Aug;47(1):115-120. Epub 2017 Mar 20 doi: 10.1016/j.semarthrit.2017.03.006. PMID: 28413100
Recurrent Pericarditis.
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173
Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence: The AIRTRIP Randomized Clinical Trial.
Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, Finetti M, Cumetti D, Carobbio A, Ruperto N, Marcolongo R, Lorini M, Rimini A, Valenti A, Erre GL, Sormani MP, Belli R, Gaita F, Martini A
JAMA 2016 Nov 8;316(18):1906-1912. doi: 10.1001/jama.2016.15826. PMID: 27825009

Diagnosis

Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis.
Collini V, Andreis A, De Biasio M, De Martino M, Isola M, Croatto N, Lepre V, Cantarini L, Merlo M, Sinagra G, Abbate A, Lazaros G, Brucato A, Klein AL, Imazio M
Open Heart 2024 Mar 15;11(1) doi: 10.1136/openhrt-2023-002599. PMID: 38490715Free PMC Article
French protocol for the diagnosis and management of familial Mediterranean fever.
Georgin-Lavialle S, Savey L, Cuisset L, Boursier G, Boffa JJ, Delplanque M, Bourguiba R, Monfort JB, Touitou I, Grateau G; Collaborators, Kone-Paut I, Hentgen V
Rev Med Interne 2023 Nov;44(11):602-616. Epub 2023 Oct 29 doi: 10.1016/j.revmed.2023.10.441. PMID: 37903671
Treat-to-target strategies for the management of familial Mediterranean Fever in children.
Ehlers L, Rolfes E, Lieber M, Müller D, Lainka E, Gohar F, Klaus G, Girschick H, Hörstermann J, Kümmerle-Deschner J, Brunner J, Palm-Beden K, Tenbrock K, von Wrangel L, Faßhauer M, Blank N, Trauzeddel R, von Stuckrad ASL, Higgins S, Welzel T, Lutz T, Hentgen V, Foell D, Wittkowski H, Kallinich T
Pediatr Rheumatol Online J 2023 Sep 26;21(1):108. doi: 10.1186/s12969-023-00875-y. PMID: 37752496Free PMC Article
An Update on Familial Mediterranean Fever.
Lancieri M, Bustaffa M, Palmeri S, Prigione I, Penco F, Papa R, Volpi S, Caorsi R, Gattorno M
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119584. PMID: 37298536Free PMC Article
Recurrent Pericarditis.
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173

Therapy

Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis.
Collini V, Andreis A, De Biasio M, De Martino M, Isola M, Croatto N, Lepre V, Cantarini L, Merlo M, Sinagra G, Abbate A, Lazaros G, Brucato A, Klein AL, Imazio M
Open Heart 2024 Mar 15;11(1) doi: 10.1136/openhrt-2023-002599. PMID: 38490715Free PMC Article
An Update on Familial Mediterranean Fever.
Lancieri M, Bustaffa M, Palmeri S, Prigione I, Penco F, Papa R, Volpi S, Caorsi R, Gattorno M
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119584. PMID: 37298536Free PMC Article
Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments.
Ozen S, Kone-Paut I, Gül A
Semin Arthritis Rheum 2017 Aug;47(1):115-120. Epub 2017 Mar 20 doi: 10.1016/j.semarthrit.2017.03.006. PMID: 28413100
Recurrent Pericarditis.
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173
Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence: The AIRTRIP Randomized Clinical Trial.
Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, Finetti M, Cumetti D, Carobbio A, Ruperto N, Marcolongo R, Lorini M, Rimini A, Valenti A, Erre GL, Sormani MP, Belli R, Gaita F, Martini A
JAMA 2016 Nov 8;316(18):1906-1912. doi: 10.1001/jama.2016.15826. PMID: 27825009

Prognosis

Gray zone in the spectrum of autoinflammatory diseases: familial Mediterranean fever accompanying periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome: single-center experience.
Konte EK, Haslak F, Yildiz M, Gucuyener N, Ulkersoy I, Gunalp A, Aslan E, Adrovic A, Sahin S, Barut K, Kasapcopur O
Eur J Pediatr 2023 Dec;182(12):5473-5482. Epub 2023 Sep 30 doi: 10.1007/s00431-023-05209-4. PMID: 37777601
Early predictors of colchicine resistance in familial Mediterranean fever.
Mosad Mosa D, Shokry D, Ahmed DB, Sobh A
Mod Rheumatol 2023 Jul 4;33(4):830-835. doi: 10.1093/mr/roac068. PMID: 35789271
The remarkable characteristics of the children with colchicine-resistant familial Mediterranean fever in Turkey.
Sahin N, Ozdemir Cicek S, Pac Kisaarslan A, Poyrazoglu MH, Gunduz Z, Dusunsel R
Mod Rheumatol 2022 Jan 5;32(1):177-185. doi: 10.1080/14397595.2021.1908502. PMID: 33775204
Recurrent Pericarditis.
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173
Recurrent Pericarditis: Modern Approach in 2016.
Imazio M, Adler Y, Charron P
Curr Cardiol Rep 2016 Jun;18(6):50. doi: 10.1007/s11886-016-0727-8. PMID: 27108360

Clinical prediction guides

Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis.
Collini V, Andreis A, De Biasio M, De Martino M, Isola M, Croatto N, Lepre V, Cantarini L, Merlo M, Sinagra G, Abbate A, Lazaros G, Brucato A, Klein AL, Imazio M
Open Heart 2024 Mar 15;11(1) doi: 10.1136/openhrt-2023-002599. PMID: 38490715Free PMC Article
Efficacy and safety of anti-interleukin-1 treatment in familial Mediterranean fever patients: a systematic review and meta-analysis.
Kilic B, Guler Y, Azman FN, Bostanci E, Ugurlu S
Rheumatology (Oxford) 2024 Apr 2;63(4):925-935. doi: 10.1093/rheumatology/kead514. PMID: 37769252
Early predictors of colchicine resistance in familial Mediterranean fever.
Mosad Mosa D, Shokry D, Ahmed DB, Sobh A
Mod Rheumatol 2023 Jul 4;33(4):830-835. doi: 10.1093/mr/roac068. PMID: 35789271
Colchicine resistance: Associated factors and its effect on health-related quality of life in patients with familial Mediterranean fever.
Erdem Gürsoy D, Gezer HH, Öz N, Özer A, Acer Kasman S, Duruöz MT
Int J Rheum Dis 2022 Nov;25(11):1239-1245. Epub 2022 Jul 29 doi: 10.1111/1756-185X.14407. PMID: 35903906
A survey of resistance to colchicine treatment for French patients with familial Mediterranean fever.
Corsia A, Georgin-Lavialle S, Hentgen V, Hachulla E, Grateau G, Faye A, Quartier P, Rossi-Semerano L, Koné-Paut I
Orphanet J Rare Dis 2017 Mar 16;12(1):54. doi: 10.1186/s13023-017-0609-1. PMID: 28302131Free PMC Article

Recent systematic reviews

Efficacy and safety of anti-interleukin-1 treatment in familial Mediterranean fever patients: a systematic review and meta-analysis.
Kilic B, Guler Y, Azman FN, Bostanci E, Ugurlu S
Rheumatology (Oxford) 2024 Apr 2;63(4):925-935. doi: 10.1093/rheumatology/kead514. PMID: 37769252
"Helicobacter pylori in familial mediterranean fever: A series of 120 patients from literature and from france".
Lacout C, Savey L, Bourguiba R, Giurgea I, Amselem S, Hoyeau N, Galland J, Amiot X, Grateau G, Ducharme-Bénard S, Georgin-Lavialle S
Helicobacter 2021 Apr;26(2):e12789. Epub 2021 Feb 15 doi: 10.1111/hel.12789. PMID: 33586832
A systematic literature review of efficacy, effectiveness and safety of biologic therapies for treatment of familial Mediterranean fever.
Kuemmerle-Deschner JB, Gautam R, George AT, Raza S, Lomax KG, Hur P
Rheumatology (Oxford) 2020 Oct 1;59(10):2711-2724. doi: 10.1093/rheumatology/keaa205. PMID: 32533192

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