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Decreased testosterone in males

MedGen UID:
395413
•Concept ID:
C1860121
•
Finding

Professional guidelines

PubMed

Treatment of Benign Prostatic Hyperplasia by Natural Drugs.
Csikós E, Horváth A, Ács K, Papp N, Balázs VL, Dolenc MS, Kenda M, Kočevar Glavač N, Nagy M, Protti M, Mercolini L, Horváth G, Farkas Á, On Behalf Of The Oemonom
Molecules 2021 Nov 25;26(23) doi: 10.3390/molecules26237141. PMID: 34885733Free PMC Article
Testosterone deficiency syndrome: Diagnosis and treatment.
García-Cruz E, Alcaraz A
Actas Urol Esp (Engl Ed) 2020 Jun;44(5):294-300. Epub 2020 May 15 doi: 10.1016/j.acuro.2019.10.009. PMID: 32423612
A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.
Lee SW, Juhasz M, Mobasher P, Ekelem C, Mesinkovska NA
J Drugs Dermatol 2018 Apr 1;17(4):457-463. PMID: 29601622Free PMC Article

Recent clinical studies

Etiology

The Role of Testosterone in the Elderly: What Do We Know?
Barone B, Napolitano L, Abate M, Cirillo L, Reccia P, Passaro F, Turco C, Morra S, Mastrangelo F, Scarpato A, Amicuzi U, Morgera V, Romano L, Calace FP, Pandolfo SD, De Luca L, Aveta A, Sicignano E, Trivellato M, Spena G, D'Alterio C, Fusco GM, Vitale R, Arcaniolo D, Crocetto F
Int J Mol Sci 2022 Mar 24;23(7) doi: 10.3390/ijms23073535. PMID: 35408895Free PMC Article
Low-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysis.
Whittaker J, Harris M
Nutr Health 2022 Dec;28(4):543-554. Epub 2022 Mar 7 doi: 10.1177/02601060221083079. PMID: 35254136Free PMC Article
Antidepressants' effects on testosterone and estrogens: What do we know?
Pavlidi P, Kokras N, Dalla C
Eur J Pharmacol 2021 May 15;899:173998. Epub 2021 Mar 4 doi: 10.1016/j.ejphar.2021.173998. PMID: 33676942
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Testosterone therapy for transgender men.
Irwig MS
Lancet Diabetes Endocrinol 2017 Apr;5(4):301-311. Epub 2016 Apr 12 doi: 10.1016/S2213-8587(16)00036-X. PMID: 27084565

Diagnosis

Hypertension in transgender individuals.
Irwig MS
J Hum Hypertens 2023 Aug;37(8):689-693. Epub 2022 Jul 13 doi: 10.1038/s41371-022-00721-w. PMID: 35831512
Obesity, type 2 diabetes, and testosterone in ageing men.
Wittert G, Grossmann M
Rev Endocr Metab Disord 2022 Dec;23(6):1233-1242. Epub 2022 Jul 14 doi: 10.1007/s11154-022-09746-5. PMID: 35834069Free PMC Article
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Aging and sex hormones in males.
Decaroli MC, Rochira V
Virulence 2017 Jul 4;8(5):545-570. Epub 2016 Nov 10 doi: 10.1080/21505594.2016.1259053. PMID: 27831823Free PMC Article
Osteoporosis in men.
Walsh JS, Eastell R
Nat Rev Endocrinol 2013 Nov;9(11):637-45. Epub 2013 Sep 10 doi: 10.1038/nrendo.2013.171. PMID: 24019112

Therapy

The Role of Testosterone in the Elderly: What Do We Know?
Barone B, Napolitano L, Abate M, Cirillo L, Reccia P, Passaro F, Turco C, Morra S, Mastrangelo F, Scarpato A, Amicuzi U, Morgera V, Romano L, Calace FP, Pandolfo SD, De Luca L, Aveta A, Sicignano E, Trivellato M, Spena G, D'Alterio C, Fusco GM, Vitale R, Arcaniolo D, Crocetto F
Int J Mol Sci 2022 Mar 24;23(7) doi: 10.3390/ijms23073535. PMID: 35408895Free PMC Article
Low-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysis.
Whittaker J, Harris M
Nutr Health 2022 Dec;28(4):543-554. Epub 2022 Mar 7 doi: 10.1177/02601060221083079. PMID: 35254136Free PMC Article
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Testosterone therapy for transgender men.
Irwig MS
Lancet Diabetes Endocrinol 2017 Apr;5(4):301-311. Epub 2016 Apr 12 doi: 10.1016/S2213-8587(16)00036-X. PMID: 27084565
Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study.
Rao A, Steels E, Inder WJ, Abraham S, Vitetta L
Aging Male 2016 Jun;19(2):134-42. Epub 2016 Jan 20 doi: 10.3109/13685538.2015.1135323. PMID: 26791805

Prognosis

Body composition and testosterone in men: a Mendelian randomization study.
Ikehata Y, Hachiya T, Kobayashi T, Ide H, Horie S
Front Endocrinol (Lausanne) 2023;14:1277393. Epub 2023 Nov 27 doi: 10.3389/fendo.2023.1277393. PMID: 38089610Free PMC Article
Psychosocial Functioning in Transgender Youth after 2 Years of Hormones.
Chen D, Berona J, Chan YM, Ehrensaft D, Garofalo R, Hidalgo MA, Rosenthal SM, Tishelman AC, Olson-Kennedy J
N Engl J Med 2023 Jan 19;388(3):240-250. doi: 10.1056/NEJMoa2206297. PMID: 36652355Free PMC Article
Late-onset hypogonadism: Prostate safety.
Miranda EP, Torres LO
Andrology 2020 Nov;8(6):1606-1613. Epub 2020 Feb 28 doi: 10.1111/andr.12772. PMID: 32056383
Testosterone and the Heart.
Goodale T, Sadhu A, Petak S, Robbins R
Methodist Debakey Cardiovasc J 2017 Apr-Jun;13(2):68-72. doi: 10.14797/mdcj-13-2-68. PMID: 28740585Free PMC Article
Power posing: brief nonverbal displays affect neuroendocrine levels and risk tolerance.
Carney DR, Cuddy AJ, Yap AJ
Psychol Sci 2010 Oct;21(10):1363-8. Epub 2010 Sep 20 doi: 10.1177/0956797610383437. PMID: 20855902

Clinical prediction guides

The Impact of Gender-Affirming Hormone Therapy on Physical Performance.
Cheung AS, Zwickl S, Miller K, Nolan BJ, Wong AFQ, Jones P, Eynon N
J Clin Endocrinol Metab 2024 Jan 18;109(2):e455-e465. doi: 10.1210/clinem/dgad414. PMID: 37437247Free PMC Article
Psychosocial Functioning in Transgender Youth after 2 Years of Hormones.
Chen D, Berona J, Chan YM, Ehrensaft D, Garofalo R, Hidalgo MA, Rosenthal SM, Tishelman AC, Olson-Kennedy J
N Engl J Med 2023 Jan 19;388(3):240-250. doi: 10.1056/NEJMoa2206297. PMID: 36652355Free PMC Article
Effects of lifelong testosterone exposure on health and disease using Mendelian randomization.
Mohammadi-Shemirani P, Chong M, Pigeyre M, Morton RW, Gerstein HC, Paré G
Elife 2020 Oct 16;9 doi: 10.7554/eLife.58914. PMID: 33063668Free PMC Article
Testosterone replacement therapy.
Barbonetti A, D'Andrea S, Francavilla S
Andrology 2020 Nov;8(6):1551-1566. Epub 2020 Mar 9 doi: 10.1111/andr.12774. PMID: 32068334
Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study.
Rao A, Steels E, Inder WJ, Abraham S, Vitetta L
Aging Male 2016 Jun;19(2):134-42. Epub 2016 Jan 20 doi: 10.3109/13685538.2015.1135323. PMID: 26791805

Recent systematic reviews

High-protein diets and testosterone.
Whittaker J
Nutr Health 2023 Jun;29(2):185-191. Epub 2022 Oct 20 doi: 10.1177/02601060221132922. PMID: 36266956Free PMC Article
Low-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysis.
Whittaker J, Harris M
Nutr Health 2022 Dec;28(4):543-554. Epub 2022 Mar 7 doi: 10.1177/02601060221083079. PMID: 35254136Free PMC Article
Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies.
Whittaker J, Wu K
J Steroid Biochem Mol Biol 2021 Jun;210:105878. Epub 2021 Mar 16 doi: 10.1016/j.jsbmb.2021.105878. PMID: 33741447
How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation.
Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL
Br J Sports Med 2021 Aug;55(15):865-872. Epub 2021 Mar 1 doi: 10.1136/bjsports-2020-103106. PMID: 33648944Free PMC Article
A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.
Lee SW, Juhasz M, Mobasher P, Ekelem C, Mesinkovska NA
J Drugs Dermatol 2018 Apr 1;17(4):457-463. PMID: 29601622Free PMC Article

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