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Susceptibility to neovascular type of age-related macular degeneration

MedGen UID:
347555
•Concept ID:
C1857814
•
Finding
Synonym: MACULAR DEGENERATION, AGE-RELATED, NEOVASCULAR TYPE, SUSCEPTIBILITY TO
 
OMIM®: 602194; 610149

Professional guidelines

PubMed

Short-term outcomes of intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 choroidal neovascularization including polypoidal choroidal vasculopathy.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Akiyama H
Sci Rep 2021 Mar 24;11(1):6759. doi: 10.1038/s41598-021-86014-7. PMID: 33762600Free PMC Article
Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes.
Leveziel N, Zerbib J, Richard F, Querques G, Morineau G, Fremeaux-Bacchi V, Coscas G, Soubrane G, Benlian P, Souied EH
Invest Ophthalmol Vis Sci 2008 Jul;49(7):3090-4. Epub 2008 Mar 24 doi: 10.1167/iovs.07-1540. PMID: 18362109

Recent clinical studies

Etiology

Complement System and Potential Therapeutics in Age-Related Macular Degeneration.
Park YG, Park YS, Kim IB
Int J Mol Sci 2021 Jun 25;22(13) doi: 10.3390/ijms22136851. PMID: 34202223Free PMC Article
Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis.
Jabbarpoor Bonyadi MH, Yaseri M, Nikkhah H, Bonyadi M, Nazari R, Soheilian M
Int Ophthalmol 2019 Apr;39(4):949-956. Epub 2018 Feb 8 doi: 10.1007/s10792-018-0853-y. PMID: 29423786
Common polymorphisms in angiogenesis.
Rogers MS, D'Amato RJ
Cold Spring Harb Perspect Med 2012 Nov 1;2(11) doi: 10.1101/cshperspect.a006510. PMID: 23125197Free PMC Article
Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease?
Laude A, Cackett PD, Vithana EN, Yeo IY, Wong D, Koh AH, Wong TY, Aung T
Prog Retin Eye Res 2010 Jan;29(1):19-29. Epub 2009 Oct 23 doi: 10.1016/j.preteyeres.2009.10.001. PMID: 19854291
Genetic susceptibility to age related macular degeneration.
Yates JR, Moore AT
J Med Genet 2000 Feb;37(2):83-7. doi: 10.1136/jmg.37.2.83. PMID: 10662806Free PMC Article

Diagnosis

Complement System and Potential Therapeutics in Age-Related Macular Degeneration.
Park YG, Park YS, Kim IB
Int J Mol Sci 2021 Jun 25;22(13) doi: 10.3390/ijms22136851. PMID: 34202223Free PMC Article
Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis.
Su Y, Hu Z, Pan T, Chen L, Xie P, Liu Q
Eur J Ophthalmol 2020 Jul;30(4):743-755. Epub 2019 Apr 12 doi: 10.1177/1120672119840245. PMID: 30974970
ENOS polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Chinese Han population.
Zuo C, Li M, Zhang X, Chen H, Su Y, Wu K, Wen F
Ophthalmic Genet 2016 Dec;37(4):394-399. Epub 2016 Feb 25 doi: 10.3109/13816810.2015.1107598. PMID: 26914548
Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis.
Fisher DE, Klein BE, Wong TY, Rotter JI, Li X, Shrager S, Burke GL, Klein R, Cotch MF
Ophthalmology 2016 Jun;123(6):1297-308. Epub 2016 Feb 16 doi: 10.1016/j.ophtha.2015.12.026. PMID: 26896123Free PMC Article
The role of oxidative stress in the pathogenesis of age-related macular degeneration.
Beatty S, Koh H, Phil M, Henson D, Boulton M
Surv Ophthalmol 2000 Sep-Oct;45(2):115-34. doi: 10.1016/s0039-6257(00)00140-5. PMID: 11033038

Therapy

Complement System and Potential Therapeutics in Age-Related Macular Degeneration.
Park YG, Park YS, Kim IB
Int J Mol Sci 2021 Jun 25;22(13) doi: 10.3390/ijms22136851. PMID: 34202223Free PMC Article
Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis.
Su Y, Hu Z, Pan T, Chen L, Xie P, Liu Q
Eur J Ophthalmol 2020 Jul;30(4):743-755. Epub 2019 Apr 12 doi: 10.1177/1120672119840245. PMID: 30974970
Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis.
Jabbarpoor Bonyadi MH, Yaseri M, Nikkhah H, Bonyadi M, Nazari R, Soheilian M
Int Ophthalmol 2019 Apr;39(4):949-956. Epub 2018 Feb 8 doi: 10.1007/s10792-018-0853-y. PMID: 29423786
Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study.
Jonasson F, Arnarsson A, Eiríksdottir G, Harris TB, Launer LJ, Meuer SM, Klein BE, Klein R, Gudnason V, Cotch MF
Ophthalmology 2011 May;118(5):825-30. Epub 2010 Dec 3 doi: 10.1016/j.ophtha.2010.08.044. PMID: 21126770Free PMC Article
The role of oxidative stress in the pathogenesis of age-related macular degeneration.
Beatty S, Koh H, Phil M, Henson D, Boulton M
Surv Ophthalmol 2000 Sep-Oct;45(2):115-34. doi: 10.1016/s0039-6257(00)00140-5. PMID: 11033038

Prognosis

Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis.
Su Y, Hu Z, Pan T, Chen L, Xie P, Liu Q
Eur J Ophthalmol 2020 Jul;30(4):743-755. Epub 2019 Apr 12 doi: 10.1177/1120672119840245. PMID: 30974970
Complement Component C3 Variant (R102G) and the Risk of Neovascular Age-Related Macular Degeneration in a Tunisian Population.
Habibi I, Sfar I, Kort F, Bouraoui R, Chebil A, Limaiem R, Ayed S, Ben Abdallah T, El Matri L, Gorgi Y
Klin Monbl Augenheilkd 2017 Apr;234(4):478-482. Epub 2017 May 3 doi: 10.1055/s-0043-104419. PMID: 28470643
Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis.
Fisher DE, Klein BE, Wong TY, Rotter JI, Li X, Shrager S, Burke GL, Klein R, Cotch MF
Ophthalmology 2016 Jun;123(6):1297-308. Epub 2016 Feb 16 doi: 10.1016/j.ophtha.2015.12.026. PMID: 26896123Free PMC Article
Common polymorphisms in angiogenesis.
Rogers MS, D'Amato RJ
Cold Spring Harb Perspect Med 2012 Nov 1;2(11) doi: 10.1101/cshperspect.a006510. PMID: 23125197Free PMC Article
The role of oxidative stress in the pathogenesis of age-related macular degeneration.
Beatty S, Koh H, Phil M, Henson D, Boulton M
Surv Ophthalmol 2000 Sep-Oct;45(2):115-34. doi: 10.1016/s0039-6257(00)00140-5. PMID: 11033038

Clinical prediction guides

Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis.
Yu Q, Zhu J, Yao Y, Sun C
Biosci Rep 2020 Apr 30;40(4) doi: 10.1042/BSR20200406. PMID: 32215612Free PMC Article
Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis.
Su Y, Hu Z, Pan T, Chen L, Xie P, Liu Q
Eur J Ophthalmol 2020 Jul;30(4):743-755. Epub 2019 Apr 12 doi: 10.1177/1120672119840245. PMID: 30974970
Identification and characterization of a novel promoter variant in placental growth factor for neovascular age-related macular degeneration.
Ma L, Ng TK, Chen H, Brelén ME, Lai TYY, Ho M, Tam POS, Young AL, Chen W, Tham CC, Pang CP, Chen LJ
Exp Eye Res 2019 Oct;187:107748. Epub 2019 Aug 1 doi: 10.1016/j.exer.2019.107748. PMID: 31377148
Genetic and functional dissection of ARMS2 in age-related macular degeneration and polypoidal choroidal vasculopathy.
Cheng Y, Huang L, Li X, Zhou P, Zeng W, Zhang C
PLoS One 2013;8(1):e53665. Epub 2013 Jan 9 doi: 10.1371/journal.pone.0053665. PMID: 23326481Free PMC Article
Common polymorphisms in angiogenesis.
Rogers MS, D'Amato RJ
Cold Spring Harb Perspect Med 2012 Nov 1;2(11) doi: 10.1101/cshperspect.a006510. PMID: 23125197Free PMC Article

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