Simultaneous enlargement of the liver and spleen.

The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.

The enteric villi are atrophic or absent.

A type of anemia caused by premature destruction of red blood cells (hemolysis).

A bacterial infection and inflammation of the skin und subcutaneous tissues.

A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma.

An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.

Abnormal accumulation of lymphocytes in the interstitium of the lung.

An autoimmune form of hemolytic anemia.

An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever.

Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.

Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.

Inflammation of the thyroid gland.

Decreased levels of immunoglobulin A (IgA).

An abnormally increased overall level of immunoglobulin E in blood.

A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales).

Increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat.

Enlargement (swelling) of a lymph node.

An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells.

Increased susceptibility to viral infections, as manifested by recurrent episodes of viral infection.

Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection.

Increased susceptibility to fungal infections, as manifested by multiple episodes of fungal infection.

An abnormal decrease from the normal count of B cells.

An abnormally low count of T cells.

The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against bacterial polysaccharides.

Chronic accumulation and overgrowth of the fungus Candida albicans on the mucous membranes of the mouth, generally manifested as associated with creamy white lesions on the tongue or inner cheeks, occasionally spreading to the gums, tonsils, palate or oropharynx.

A decreased proliferative response of lymphocytes in vitro or in vivo, when stimulated with an anti-CD3 antibody against the T-cell co-receptor, CD3.

An abnormally decreased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells.

An unusually severe form of varicella zoster virus (VZV) infection. In the majority of the cases, especially in children, varicella is a very mild infection characterized by skin lesions, low grade fever and malaise. Severe infection is characterized by manifestations including VZV pneumonia, hepatitis, meningitis, and disseminated varicella.

Type 1 diabetes mellitus (T1D), also designated insulin-dependent diabetes mellitus (IDDM), is a disorder of glucose homeostasis characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of T1D have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classic phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Nasal ridge curving posteriorly to an imaginary line that connects the nasal root and tip.

Forward prominence of the entire forehead, due to protrusion of the frontal bone.

Refers to the loss of the outer layer of the epidermis in large, scale-like flakes.

Alopecia areata is a common disorder that causes hair loss. "Alopecia" is a Latin term that means baldness, and "areata" refers to the patchy nature of the hair loss that is typically seen with this condition.\n\nIn most people with alopecia areata, hair falls out in small, round patches, leaving coin-sized areas of bare skin. This patchy hair loss occurs most often on the scalp but can affect other parts of the body as well. Uncommonly, the hair loss involves the entire scalp (in which case the condition is known as alopecia totalis) or the whole body (alopecia universalis). Other rare forms of alopecia areata, which have different patterns of hair loss, have also been reported.\n\nAlopecia areata affects people of all ages, although it most commonly appears in adolescence or early adulthood. Hair loss occurs over a period of weeks. The hair usually grows back after several months, although it may fall out again. In some cases, unpredictable cycles of hair loss followed by regrowth can last for years. In addition to hair loss, some affected individuals have fingernail and toenail abnormalities, such as pits on the surface of the nails.\n\nThe hair loss associated with alopecia areata is not painful or disabling. However, it causes changes in a person's appearance that can profoundly affect quality of life and self-esteem. In some people, the condition can lead to depression, anxiety, and other emotional or psychological issues.

Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.

Deficiency of thyroid hormone.