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Aldosterone to renin ratio, increased

MedGen UID:
377644
•Concept ID:
C1852324
•
Finding
Synonyms: ALDOSTERONE TO RENIN RATIO, INCREASED; Increased aldosterone:renin ratio
 
OMIM®: 124080

Professional guidelines

PubMed

Primary aldosteronism.
Funder J
Trends Cardiovasc Med 2022 May;32(4):228-233. Epub 2021 Mar 26 doi: 10.1016/j.tcm.2021.03.005. PMID: 33775861
Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort.
Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, Beuschlein F, Kitamoto KK, Pham U, Morimoto R, Umakoshi H, Prejbisz A, Kocjan T, Naruse M, Stowasser M, Nishikawa T, Young WF Jr, Gomez-Sanchez CE, Funder JW, Reincke M; Primary Aldosteronism Surgery Outcome (PASO) investigators
Lancet Diabetes Endocrinol 2017 Sep;5(9):689-699. Epub 2017 May 30 doi: 10.1016/S2213-8587(17)30135-3. PMID: 28576687Free PMC Article
Diagnosis of hypokalemia: a problem-solving approach to clinical cases.
Assadi F
Iran J Kidney Dis 2008 Jul;2(3):115-22. PMID: 19377223

Recent clinical studies

Therapy

Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial.
Laffin LJ, Rodman D, Luther JM, Vaidya A, Weir MR, Rajicic N, Slingsby BT, Nissen SE; Target-HTN Investigators
JAMA 2023 Sep 26;330(12):1140-1150. doi: 10.1001/jama.2023.16029. PMID: 37690061Free PMC Article
Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials.
Neuen BL, Oshima M, Agarwal R, Arnott C, Cherney DZ, Edwards R, Langkilde AM, Mahaffey KW, McGuire DK, Neal B, Perkovic V, Pong A, Sabatine MS, Raz I, Toyama T, Wanner C, Wheeler DC, Wiviott SD, Zinman B, Heerspink HJL
Circulation 2022 May 10;145(19):1460-1470. Epub 2022 Apr 8 doi: 10.1161/CIRCULATIONAHA.121.057736. PMID: 35394821
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.
Agarwal R, Sinha AD, Cramer AE, Balmes-Fenwick M, Dickinson JH, Ouyang F, Tu W
N Engl J Med 2021 Dec 30;385(27):2507-2519. Epub 2021 Nov 5 doi: 10.1056/NEJMoa2110730. PMID: 34739197Free PMC Article
Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease.
Chung EY, Ruospo M, Natale P, Bolignano D, Navaneethan SD, Palmer SC, Strippoli GF
Cochrane Database Syst Rev 2020 Oct 27;10(10):CD007004. doi: 10.1002/14651858.CD007004.pub4. PMID: 33107592Free PMC Article
Diagnosis of hypokalemia: a problem-solving approach to clinical cases.
Assadi F
Iran J Kidney Dis 2008 Jul;2(3):115-22. PMID: 19377223

Prognosis

Laboratory medicine in arterial hypertension.
Aralica M, Šupak-Smolčić V, Honović L, Franin L, Šonjić P, Šimac M, Horvat M, Poropat N
Biochem Med (Zagreb) 2023 Feb 15;33(1):010501. doi: 10.11613/BM.2023.010501. PMID: 36817852Free PMC Article
Gitelman Syndrome.
Mustafa QU, Haroon ZH, Ijaz A, Sajid MT, Ayyub M
J Coll Physicians Surg Pak 2017 Mar;27(3):S30-S32. PMID: 28302238
Hyperaldosteronism: Screening and Diagnostic Tests.
Sabbadin C, Fallo F
High Blood Press Cardiovasc Prev 2016 Jun;23(2):69-72. Epub 2016 Mar 14 doi: 10.1007/s40292-016-0136-5. PMID: 26971505
Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker withdrawal in advanced renal disease: the STOP-ACEi trial.
Bhandari S, Ives N, Brettell EA, Valente M, Cockwell P, Topham PS, Cleland JG, Khwaja A, El Nahas M
Nephrol Dial Transplant 2016 Feb;31(2):255-61. Epub 2015 Sep 30 doi: 10.1093/ndt/gfv346. PMID: 26429974Free PMC Article
Adrenal incidentaloma.
Arnaldi G, Masini AM, Giacchetti G, Taccaliti A, Faloia E, Mantero F
Braz J Med Biol Res 2000 Oct;33(10):1177-89. doi: 10.1590/s0100-879x2000001000007. PMID: 11004718

Clinical prediction guides

Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial.
Caprio M, Moriconi E, Camajani E, Feraco A, Marzolla V, Vitiello L, Proietti S, Armani A, Gorini S, Mammi C, Egeo G, Aurilia C, Fiorentini G, Tomino C, Barbanti P
J Transl Med 2023 Oct 4;21(1):692. doi: 10.1186/s12967-023-04561-1. PMID: 37794395Free PMC Article
Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial.
Laffin LJ, Rodman D, Luther JM, Vaidya A, Weir MR, Rajicic N, Slingsby BT, Nissen SE; Target-HTN Investigators
JAMA 2023 Sep 26;330(12):1140-1150. doi: 10.1001/jama.2023.16029. PMID: 37690061Free PMC Article
Effects of Dapagliflozin in Chronic Kidney Disease, With and Without Other Cardiovascular Medications: DAPA-CKD Trial.
Chertow GM, Correa-Rotter R, Vart P, Jongs N, McMurray JJV, Rossing P, Langkilde AM, Sjöström CD, Toto RD, Wheeler DC, Heerspink HJL; DAPA‐CKD Trial Committees and Investigators
J Am Heart Assoc 2023 May 2;12(9):e028739. Epub 2023 Apr 29 doi: 10.1161/JAHA.122.028739. PMID: 37119064Free PMC Article
Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials.
Neuen BL, Oshima M, Agarwal R, Arnott C, Cherney DZ, Edwards R, Langkilde AM, Mahaffey KW, McGuire DK, Neal B, Perkovic V, Pong A, Sabatine MS, Raz I, Toyama T, Wanner C, Wheeler DC, Wiviott SD, Zinman B, Heerspink HJL
Circulation 2022 May 10;145(19):1460-1470. Epub 2022 Apr 8 doi: 10.1161/CIRCULATIONAHA.121.057736. PMID: 35394821
Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743

Recent systematic reviews

The efficacy and safety of sacubitril/valsartan in chronic kidney disease: a systematic review and meta-analysis.
Zhou W, Yang X, Jin J, Cheng M, Li Y, Bai Y, Xu J
Int Urol Nephrol 2024 Jan;56(1):181-190. Epub 2023 May 17 doi: 10.1007/s11255-023-03599-w. PMID: 37195574
Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Association between antihypertensive treatment and adverse events: systematic review and meta-analysis.
Albasri A, Hattle M, Koshiaris C, Dunnigan A, Paxton B, Fox SE, Smith M, Archer L, Levis B, Payne RA, Riley RD, Roberts N, Snell KIE, Lay-Flurrie S, Usher-Smith J, Stevens R, Hobbs FDR, McManus RJ, Sheppard JP; STRATIFY investigators
BMJ 2021 Feb 10;372:n189. doi: 10.1136/bmj.n189. PMID: 33568342Free PMC Article
Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease.
Chung EY, Ruospo M, Natale P, Bolignano D, Navaneethan SD, Palmer SC, Strippoli GF
Cochrane Database Syst Rev 2020 Oct 27;10(10):CD007004. doi: 10.1002/14651858.CD007004.pub4. PMID: 33107592Free PMC Article
Effectiveness of Quality Improvement Strategies for the Management of CKD: A Meta-Analysis.
Silver SA, Bell CM, Chertow GM, Shah PS, Shojania K, Wald R, Harel Z
Clin J Am Soc Nephrol 2017 Oct 6;12(10):1601-1614. Epub 2017 Sep 6 doi: 10.2215/CJN.02490317. PMID: 28877926Free PMC Article

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