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Insulin resistance, susceptibility to

MedGen UID:
343716
•Concept ID:
C1852091
•
Finding
Synonym: INSULIN RESISTANCE, SUSCEPTIBILITY TO
 
OMIM®: 125853; 142410; 147545; 173335; 176885; 600917

Professional guidelines

PubMed

Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment.
Thankamony A, Jensen RB, O'Connell SM, Day F, Kirk J, Donaldson M, Ivarsson SA, Söder O, Roche E, Hoey H, Ong KK, Dunger DB, Juul A
J Clin Endocrinol Metab 2016 Jan;101(1):131-42. Epub 2015 Nov 20 doi: 10.1210/jc.2015-3019. PMID: 26588449Free PMC Article

Recent clinical studies

Etiology

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021.
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI
Int J Mol Sci 2022 Jan 12;23(2) doi: 10.3390/ijms23020786. PMID: 35054972Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Genetics of Insulin Resistance and the Metabolic Syndrome.
Brown AE, Walker M
Curr Cardiol Rep 2016 Aug;18(8):75. doi: 10.1007/s11886-016-0755-4. PMID: 27312935Free PMC Article
Metabolic syndrome.
Samson SL, Garber AJ
Endocrinol Metab Clin North Am 2014 Mar;43(1):1-23. doi: 10.1016/j.ecl.2013.09.009. PMID: 24582089
Risk factors for type 2 diabetes mellitus.
Fletcher B, Gulanick M, Lamendola C
J Cardiovasc Nurs 2002 Jan;16(2):17-23. doi: 10.1097/00005082-200201000-00003. PMID: 11800065

Diagnosis

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021.
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI
Int J Mol Sci 2022 Jan 12;23(2) doi: 10.3390/ijms23020786. PMID: 35054972Free PMC Article
Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease.
Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2021 Aug 26;22(17) doi: 10.3390/ijms22179221. PMID: 34502127Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Polycystic Ovary Syndrome.
Azziz R
Obstet Gynecol 2018 Aug;132(2):321-336. doi: 10.1097/AOG.0000000000002698. PMID: 29995717
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.
Diamanti-Kandarakis E, Dunaif A
Endocr Rev 2012 Dec;33(6):981-1030. Epub 2012 Oct 12 doi: 10.1210/er.2011-1034. PMID: 23065822Free PMC Article

Therapy

Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome.
Green M, Arora K, Prakash S
Int J Mol Sci 2020 Apr 21;21(8) doi: 10.3390/ijms21082890. PMID: 32326175Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
l-Citrulline Supplementation: Impact on Cardiometabolic Health.
Allerton TD, Proctor DN, Stephens JM, Dugas TR, Spielmann G, Irving BA
Nutrients 2018 Jul 19;10(7) doi: 10.3390/nu10070921. PMID: 30029482Free PMC Article
Klinefelter syndrome: more than hypogonadism.
Kanakis GA, Nieschlag E
Metabolism 2018 Sep;86:135-144. Epub 2018 Jan 31 doi: 10.1016/j.metabol.2017.09.017. PMID: 29382506
Insulin and the polycystic ovary syndrome.
Macut D, Bjekić-Macut J, Rahelić D, Doknić M
Diabetes Res Clin Pract 2017 Aug;130:163-170. Epub 2017 Jun 12 doi: 10.1016/j.diabres.2017.06.011. PMID: 28646699

Prognosis

The cause-effect relation of tuberculosis on incidence of diabetes mellitus.
Bisht MK, Dahiya P, Ghosh S, Mukhopadhyay S
Front Cell Infect Microbiol 2023;13:1134036. Epub 2023 Jun 26 doi: 10.3389/fcimb.2023.1134036. PMID: 37434784Free PMC Article
Epidemiology of Hepatocellular Carcinoma.
McGlynn KA, Petrick JL, El-Serag HB
Hepatology 2021 Jan;73 Suppl 1(Suppl 1):4-13. Epub 2020 Nov 24 doi: 10.1002/hep.31288. PMID: 32319693Free PMC Article
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J
Int J Mol Sci 2020 Apr 10;21(7) doi: 10.3390/ijms21072632. PMID: 32290082Free PMC Article
The Genetic Epidemiology of Type 2 Diabetes: Opportunities for Health Translation.
Meigs JB
Curr Diab Rep 2019 Jul 22;19(8):62. doi: 10.1007/s11892-019-1173-y. PMID: 31332628Free PMC Article
Impacts of shift work on sleep and circadian rhythms.
Boivin DB, Boudreau P
Pathol Biol (Paris) 2014 Oct;62(5):292-301. Epub 2014 Sep 20 doi: 10.1016/j.patbio.2014.08.001. PMID: 25246026

Clinical prediction guides

Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease.
Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2021 Aug 26;22(17) doi: 10.3390/ijms22179221. PMID: 34502127Free PMC Article
Precision Nutrition for Alzheimer's Prevention in ApoE4 Carriers.
Norwitz NG, Saif N, Ariza IE, Isaacson RS
Nutrients 2021 Apr 19;13(4) doi: 10.3390/nu13041362. PMID: 33921683Free PMC Article
The Genetic Epidemiology of Type 2 Diabetes: Opportunities for Health Translation.
Meigs JB
Curr Diab Rep 2019 Jul 22;19(8):62. doi: 10.1007/s11892-019-1173-y. PMID: 31332628Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Genetics of Insulin Resistance and the Metabolic Syndrome.
Brown AE, Walker M
Curr Cardiol Rep 2016 Aug;18(8):75. doi: 10.1007/s11886-016-0755-4. PMID: 27312935Free PMC Article

Recent systematic reviews

Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review.
Ma S, Wang Y, Ji X, Dong S, Wang S, Zhang S, Deng F, Chen J, Lin B, Khan BA, Liu W, Hou K
Front Cell Infect Microbiol 2024;14:1364545. Epub 2024 May 28 doi: 10.3389/fcimb.2024.1364545. PMID: 38868299Free PMC Article
Prevalence of sarcopenic obesity in patients with diabetes and adverse outcomes: A systematic review and meta-analysis.
Zhou YY, Wang JF, Yao Q, Jian QF, Luo ZP
Clin Nutr ESPEN 2023 Dec;58:128-135. Epub 2023 Sep 29 doi: 10.1016/j.clnesp.2023.09.920. PMID: 38056996
Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials.
Martinez-Herrera M, Silvestre-Rangil J, Silvestre FJ
Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e708-e715. doi: 10.4317/medoral.21786. PMID: 29053651Free PMC Article
A Systematic Review on Sasang Constitutional Type-Associated Susceptibility to Disorders in Korea.
Lee HY, Lee WJ, Kim HW, Jang ES, Ahn YC, Ku BC, Kang W, Lee SW, Son CG
J Altern Complement Med 2016 Dec;22(12):950-956. Epub 2016 Oct 18 doi: 10.1089/acm.2016.0177. PMID: 27754711
The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis.
Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS
Sports Med 2015 May;45(5):679-92. doi: 10.1007/s40279-015-0321-z. PMID: 25771785

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