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Lewy Body Variant of Alzheimer Disease

MedGen UID:
343692
•Concept ID:
C1851958
•
Disease or Syndrome
Synonym: LEWY BODY VARIANT OF ALZHEIMER DISEASE
 
OMIM®: 127750

Recent clinical studies

Etiology

Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease.
McKeith I, Taylor JP, Thomas A, Donaghy P, Kane J
J Geriatr Psychiatry Neurol 2016 Sep;29(5):249-53. doi: 10.1177/0891988716656083. PMID: 27502299
Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease.
Serby M, Brickman AM, Haroutunian V, Purohit DP, Marin D, Lantz M, Mohs RC, Davis KL
Am J Geriatr Psychiatry 2003 May-Jun;11(3):371-4. PMID: 12724118
Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: a comparison with classic Alzheimer disease and normal aging.
Brown DF, Risser RC, Bigio EH, Tripp P, Stiegler A, Welch E, Eagan KP, Hladik CL, White CL 3rd
J Neuropathol Exp Neurol 1998 Oct;57(10):955-60. doi: 10.1097/00005072-199810000-00007. PMID: 9786245
Neuropathologic evidence that the Lewy body variant of Alzheimer disease represents coexistence of Alzheimer disease and idiopathic Parkinson disease.
Brown DF, Dababo MA, Bigio EH, Risser RC, Eagan KP, Hladik CL, White CL 3rd
J Neuropathol Exp Neurol 1998 Jan;57(1):39-46. doi: 10.1097/00005072-199801000-00006. PMID: 9600196

Diagnosis

Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease.
McKeith I, Taylor JP, Thomas A, Donaghy P, Kane J
J Geriatr Psychiatry Neurol 2016 Sep;29(5):249-53. doi: 10.1177/0891988716656083. PMID: 27502299
Clinical symptoms and symptom signatures of Alzheimer's disease subgroups.
Iqbal K, Flory M, Soininen H
J Alzheimers Dis 2013;37(3):475-81. doi: 10.3233/JAD-130899. PMID: 24002184
Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease.
Serby M, Brickman AM, Haroutunian V, Purohit DP, Marin D, Lantz M, Mohs RC, Davis KL
Am J Geriatr Psychiatry 2003 May-Jun;11(3):371-4. PMID: 12724118
Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease.
Sabbagh MN, Corey-Bloom J, Tiraboschi P, Thomas R, Masliah E, Thal LJ
Arch Neurol 1999 Dec;56(12):1458-61. doi: 10.1001/archneur.56.12.1458. PMID: 10593300
The Lewy body variant of Alzheimer disease.
Hansen LA
J Neural Transm Suppl 1997;51:83-93. doi: 10.1007/978-3-7091-6846-2_7. PMID: 9470130

Therapy

Neuropathologic evidence that the Lewy body variant of Alzheimer disease represents coexistence of Alzheimer disease and idiopathic Parkinson disease.
Brown DF, Dababo MA, Bigio EH, Risser RC, Eagan KP, Hladik CL, White CL 3rd
J Neuropathol Exp Neurol 1998 Jan;57(1):39-46. doi: 10.1097/00005072-199801000-00006. PMID: 9600196

Prognosis

Clinical symptoms and symptom signatures of Alzheimer's disease subgroups.
Iqbal K, Flory M, Soininen H
J Alzheimers Dis 2013;37(3):475-81. doi: 10.3233/JAD-130899. PMID: 24002184
A sporadic case of Creutzfeldt-Jakob disease with beta-amyloid deposits and alpha-synuclein inclusions.
Vital A, Canron MH, Gil R, Hauw JJ, Vital C
Neuropathology 2007 Jun;27(3):273-7. doi: 10.1111/j.1440-1789.2007.00755.x. PMID: 17645242
Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease.
Sabbagh MN, Corey-Bloom J, Tiraboschi P, Thomas R, Masliah E, Thal LJ
Arch Neurol 1999 Dec;56(12):1458-61. doi: 10.1001/archneur.56.12.1458. PMID: 10593300

Clinical prediction guides

Clinical symptoms and symptom signatures of Alzheimer's disease subgroups.
Iqbal K, Flory M, Soininen H
J Alzheimers Dis 2013;37(3):475-81. doi: 10.3233/JAD-130899. PMID: 24002184
A sporadic case of Creutzfeldt-Jakob disease with beta-amyloid deposits and alpha-synuclein inclusions.
Vital A, Canron MH, Gil R, Hauw JJ, Vital C
Neuropathology 2007 Jun;27(3):273-7. doi: 10.1111/j.1440-1789.2007.00755.x. PMID: 17645242
Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease.
Sabbagh MN, Corey-Bloom J, Tiraboschi P, Thomas R, Masliah E, Thal LJ
Arch Neurol 1999 Dec;56(12):1458-61. doi: 10.1001/archneur.56.12.1458. PMID: 10593300

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