Diffuse hepatic steatosis

MedGen UID:: 341511
•Concept ID:: C1849686
•: Finding

Synonym:	Hepatic steatosis, diffuse

HPO:	HP:0006555

Definition

A diffuse form of hepatic steatosis. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDiffuse hepatic steatosis

Abnormality of the liver
- Abnormal liver morphology
  - Abnormal liver metabolite concentration
    - Storage in hepatocytes
      - Lipid accumulation in hepatocytes
        Hepatic steatosis
        Diffuse hepatic steatosis

Conditions with this feature

Acyl-CoA oxidase deficiency

MedGen UID:: 376636
•Concept ID:: C1849678
•: Disease or Syndrome

Peroxisomal acyl-CoA oxidase deficiency is a disorder of peroxisomal fatty acid beta-oxidation. See also D-bifunctional protein deficiency (261515), caused by mutation in the HSD17B4 gene (601860) on chromosome 5q2. The clinical manifestations of these 2 deficiencies are similar to those of disorders of peroxisomal assembly, including Zellweger cerebrohepatorenal syndrome (see 214100) and neonatal adrenoleukodystrophy (see 601539) (Watkins et al., 1995).

See: Condition Record

Acyl-CoA oxidase deficiency

Professional guidelines

PubMed

Pediatric NAFLD: an overview and recent developments in diagnostics and treatment.

Draijer L, Benninga M, Koot B
Expert Rev Gastroenterol Hepatol 2019 May;13(5):447-461. Epub 2019 Apr 4 doi: 10.1080/17474124.2019.1595589. PMID: 30875479

Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis.

Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L
World J Gastroenterol 2018 Aug 14;24(30):3361-3373. doi: 10.3748/wjg.v24.i30.3361. PMID: 30122876 Free PMC Article

Assessing the Non-tumorous Liver: Implications for Patient Management and Surgical Therapy.

Pandey P, Pandey A, Dillhoff M, Schmidt C, Kamel IR, Pawlik TM
J Gastrointest Surg 2018 Feb;22(2):344-360. Epub 2017 Sep 18 doi: 10.1007/s11605-017-3562-3. PMID: 28924922

See all (18)

Recent clinical studies

Etiology

Impact of Porphyromonas gingivalis-odontogenic infection on the pathogenesis of non-alcoholic fatty liver disease.

Liu L, Geng Y, Xiong C
Ann Med 2023;55(2):2255825. doi: 10.1080/07853890.2023.2255825. PMID: 37708866 Free PMC Article

Lobar hepatic steatosis: Association with portal flow hemodynamics evaluated by multiphasic dynamic contrast-enhanced CT.

Kawano Y, Tanabe M, Kameda F, Higashi M, Ihara K, Tanabe M, Inoue A, Kobayashi T, Ueda T, Ito K
Eur J Radiol 2023 Mar;160:110688. Epub 2023 Jan 5 doi: 10.1016/j.ejrad.2023.110688. PMID: 36630843

Quantitative assessment of the hepatic metabolic volume product in patients with diffuse hepatic steatosis and normal controls through use of FDG-PET and MR imaging: a novel concept.

Bural GG, Torigian DA, Burke A, Houseni M, Alkhawaldeh K, Cucchiara A, Basu S, Alavi A
Mol Imaging Biol 2010 Jun;12(3):233-9. Epub 2009 Oct 6 doi: 10.1007/s11307-009-0258-4. PMID: 19806406

See all (3)

Diagnosis

Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates.

Kamath S, Chavez AO, Gastaldelli A, Casiraghi F, Halff GA, Abrahamian GA, Davalli AM, Bastarrachea RA, Comuzzie AG, Guardado-Mendoza R, Jimenez-Ceja LM, Mattern V, Paez AM, Ricotti A, Tejero ME, Higgins PB, Rodriguez-Sanchez IP, Tripathy D, DeFronzo RA, Dick EJ Jr, Cline GW, Folli F
PLoS One 2011;6(11):e27617. Epub 2011 Nov 18 doi: 10.1371/journal.pone.0027617. PMID: 22125617 Free PMC Article

Quantitative assessment of the hepatic metabolic volume product in patients with diffuse hepatic steatosis and normal controls through use of FDG-PET and MR imaging: a novel concept.

Bural GG, Torigian DA, Burke A, Houseni M, Alkhawaldeh K, Cucchiara A, Basu S, Alavi A
Mol Imaging Biol 2010 Jun;12(3):233-9. Epub 2009 Oct 6 doi: 10.1007/s11307-009-0258-4. PMID: 19806406

Imaging of hepatic steatosis.

Siegelman ES, Rosen MA
Semin Liver Dis 2001;21(1):71-80. doi: 10.1055/s-2001-12930. PMID: 11296698

MR imaging of diffuse liver disease. Hepatic fat and iron.

Siegelman ES
Magn Reson Imaging Clin N Am 1997 May;5(2):347-65. PMID: 9113679

A congenital anomaly of vitamin B12 metabolism: a study of three cases.

Russo P, Doyon J, Sonsino E, Ogier H, Saudubray JM
Hum Pathol 1992 May;23(5):504-12. doi: 10.1016/0046-8177(92)90127-o. PMID: 1568746

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