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Glaucoma, normal tension, susceptibility to(NTG)

MedGen UID:
335756
•Concept ID:
C1847730
•
Finding
Synonyms: GLAUCOMA, NORMAL PRESSURE, SUSCEPTIBILITY TO; NTG
 
Genes (locations): OPA1 (3q29); OPTN (10p13)
 
Monarch Initiative: MONDO:0011693
OMIM®: 606657

Professional guidelines

PubMed

Association between optic atrophy 1 polymorphisms and primary open angle glaucoma risk: Based on a meta-analysis.
Liu YF, Luo XY, Zhao ZC, Zheng W, Lv HY, Luo WM
Eur J Ophthalmol 2024 May;34(3):708-718. Epub 2023 Oct 23 doi: 10.1177/11206721231208244. PMID: 37872653
Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype-phenotype correlations in southern Chinese population.
Wu Z, Huang C, Zheng Y, Yuan XL, Chen S, Xu Y, Chen LJ, Pang CP, Zhang M, Ng TK
Mol Genet Genomics 2023 Nov;298(6):1343-1352. Epub 2023 Jul 29 doi: 10.1007/s00438-023-02058-6. PMID: 37516687

Recent clinical studies

Etiology

Rodent genetically modified models of glaucoma.
Loo Y, Chan ASY, Khor CC, Aung T, Wang Z
Mol Aspects Med 2024 Feb;95:101229. Epub 2023 Nov 30 doi: 10.1016/j.mam.2023.101229. PMID: 38039744
Relationship of axial length and corneal biomechanical properties with susceptibility to unilateral normal-tension glaucoma.
Chen YY, Wang TH, Huang JY, Su CC
Graefes Arch Clin Exp Ophthalmol 2022 Jan;260(1):255-264. Epub 2021 Aug 19 doi: 10.1007/s00417-021-05346-2. PMID: 34410485
EAAT1 variants associated with glaucoma.
Yanagisawa M, Namekata K, Aida T, Katou S, Takeda T, Harada T, Fuse N, The Glaucoma Gene Research Group, Tanaka K
Biochem Biophys Res Commun 2020 Sep 3;529(4):943-949. Epub 2020 Jul 30 doi: 10.1016/j.bbrc.2020.06.099. PMID: 32819603
Genetics of glaucoma.
Wiggs JL, Pasquale LR
Hum Mol Genet 2017 Aug 1;26(R1):R21-R27. doi: 10.1093/hmg/ddx184. PMID: 28505344Free PMC Article
TBK1 gene duplication and normal-tension glaucoma.
Ritch R, Darbro B, Menon G, Khanna CL, Solivan-Timpe F, Roos BR, Sarfarzi M, Kawase K, Yamamoto T, Robin AL, Lotery AJ, Fingert JH
JAMA Ophthalmol 2014 May;132(5):544-8. doi: 10.1001/jamaophthalmol.2014.104. PMID: 24699864Free PMC Article

Diagnosis

Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis.
Pan L, Wu J, Wang N
Genes (Basel) 2024 Apr 14;15(4) doi: 10.3390/genes15040491. PMID: 38674425Free PMC Article
Relationship of axial length and corneal biomechanical properties with susceptibility to unilateral normal-tension glaucoma.
Chen YY, Wang TH, Huang JY, Su CC
Graefes Arch Clin Exp Ophthalmol 2022 Jan;260(1):255-264. Epub 2021 Aug 19 doi: 10.1007/s00417-021-05346-2. PMID: 34410485
Analysis of association between MALAT1 haplotype and the severity of normal-tension glaucoma (NTG).
Yue JL, Zheng SF
J Cell Mol Med 2021 Nov;25(21):9918-9926. Epub 2021 Oct 2 doi: 10.1111/jcmm.15906. PMID: 34599867Free PMC Article
Central retinal vascular trunk deviation in unilateral normal-tension glaucoma.
Choung HK, Kim M, Oh S, Lee KM, Kim SH
PLoS One 2021;16(7):e0254889. Epub 2021 Jul 20 doi: 10.1371/journal.pone.0254889. PMID: 34283884Free PMC Article
Genetics of glaucoma.
Wiggs JL, Pasquale LR
Hum Mol Genet 2017 Aug 1;26(R1):R21-R27. doi: 10.1093/hmg/ddx184. PMID: 28505344Free PMC Article

Therapy

Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis.
Pan L, Wu J, Wang N
Genes (Basel) 2024 Apr 14;15(4) doi: 10.3390/genes15040491. PMID: 38674425Free PMC Article
Risk of Glaucoma in Patients Receiving Hemodialysis and Peritoneal Dialysis: A Nationwide Population-Based Cohort Study.
Lim CC, Lee CY, Huang FC, Huang JY, Hung JH, Yang SF
Int J Environ Res Public Health 2020 Sep 17;17(18) doi: 10.3390/ijerph17186774. PMID: 32957502Free PMC Article
Roles of tumor necrosis factor alpha gene polymorphisms, tumor necrosis factor alpha level in aqueous humor, and the risks of open angle glaucoma: a meta-analysis.
Xin X, Gao L, Wu T, Sun F
Mol Vis 2013;19:526-35. Epub 2013 Feb 27 PMID: 23559847Free PMC Article
Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.
Nakamura-Yanagidaira T, Takahashi Y, Sano K, Murata T, Hayashi T
Mol Vis 2011;17:2157-70. Epub 2011 Aug 11 PMID: 21850191Free PMC Article
Beta-blocker eyedrops and nocturnal arterial hypotension.
Hayreh SS, Podhajsky P, Zimmerman MB
Am J Ophthalmol 1999 Sep;128(3):301-9. doi: 10.1016/s0002-9394(99)00160-9. PMID: 10511024

Prognosis

Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype-phenotype correlations in southern Chinese population.
Wu Z, Huang C, Zheng Y, Yuan XL, Chen S, Xu Y, Chen LJ, Pang CP, Zhang M, Ng TK
Mol Genet Genomics 2023 Nov;298(6):1343-1352. Epub 2023 Jul 29 doi: 10.1007/s00438-023-02058-6. PMID: 37516687
Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma.
Beutgen VM, Pfeiffer N, Grus FH
Front Immunol 2021;12:616421. Epub 2021 Feb 19 doi: 10.3389/fimmu.2021.616421. PMID: 33679756Free PMC Article
Lack of Correlation between ASB10 and Normal-tension Glaucoma in a Population from the Republic of Korea.
Jung SH, Lee YC, Lee MY, Shin HY
Curr Eye Res 2020 Apr;45(4):521-525. Epub 2019 Oct 7 doi: 10.1080/02713683.2019.1668949. PMID: 31522561
Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea.
Jung SH, Lee YC, Lee MY, Shin HY
Graefes Arch Clin Exp Ophthalmol 2019 Dec;257(12):2717-2721. Epub 2019 Sep 11 doi: 10.1007/s00417-019-04467-z. PMID: 31512042
TBK1 gene duplication and normal-tension glaucoma.
Ritch R, Darbro B, Menon G, Khanna CL, Solivan-Timpe F, Roos BR, Sarfarzi M, Kawase K, Yamamoto T, Robin AL, Lotery AJ, Fingert JH
JAMA Ophthalmol 2014 May;132(5):544-8. doi: 10.1001/jamaophthalmol.2014.104. PMID: 24699864Free PMC Article

Clinical prediction guides

Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype-phenotype correlations in southern Chinese population.
Wu Z, Huang C, Zheng Y, Yuan XL, Chen S, Xu Y, Chen LJ, Pang CP, Zhang M, Ng TK
Mol Genet Genomics 2023 Nov;298(6):1343-1352. Epub 2023 Jul 29 doi: 10.1007/s00438-023-02058-6. PMID: 37516687
No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma.
Lee JS, Jeoung JW, Oh S, Kim DM, Ahn JH, Kim MJ, Seong MW, Park SS, Kim JY
Ophthalmic Genet 2020 Oct;41(5):427-431. Epub 2020 Jun 28 doi: 10.1080/13816810.2020.1783690. PMID: 32597291
Lack of Correlation between ASB10 and Normal-tension Glaucoma in a Population from the Republic of Korea.
Jung SH, Lee YC, Lee MY, Shin HY
Curr Eye Res 2020 Apr;45(4):521-525. Epub 2019 Oct 7 doi: 10.1080/02713683.2019.1668949. PMID: 31522561
Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea.
Jung SH, Lee YC, Lee MY, Shin HY
Graefes Arch Clin Exp Ophthalmol 2019 Dec;257(12):2717-2721. Epub 2019 Sep 11 doi: 10.1007/s00417-019-04467-z. PMID: 31512042
DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma.
Burdon KP, Awadalla MS, Mitchell P, Wang JJ, White A, Keane MC, Souzeau E, Graham SL, Goldberg I, Healey PR, Landers J, Mills RAD, Best S, Hewitt AW, Sharma S, Craig JE
Ophthalmic Genet 2018 Apr;39(2):221-227. Epub 2017 Dec 21 doi: 10.1080/13816810.2017.1413659. PMID: 29265947

Recent systematic reviews

Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis.
Pan L, Wu J, Wang N
Genes (Basel) 2024 Apr 14;15(4) doi: 10.3390/genes15040491. PMID: 38674425Free PMC Article
The association of toll-like receptor 4 gene polymorphisms with primary open angle glaucoma susceptibility: a meta-analysis.
Chaiwiang N, Poyomtip T
Biosci Rep 2019 Apr 30;39(4) Epub 2019 Apr 2 doi: 10.1042/BSR20190029. PMID: 30877182Free PMC Article
Association of WDR36 polymorphisms with primary open angle glaucoma: A systematic review and meta-analysis.
Liu K, He W, Zhao J, Zeng Y, Cheng H
Medicine (Baltimore) 2017 Jun;96(26):e7291. doi: 10.1097/MD.0000000000007291. PMID: 28658128Free PMC Article
Association of TP53 polymorphisms with primary open-angle glaucoma: a meta-analysis.
Guo Y, Zhang H, Chen X, Yang X, Cheng W, Zhao K
Invest Ophthalmol Vis Sci 2012 Jun 20;53(7):3756-63. doi: 10.1167/iovs.12-9818. PMID: 22562509

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