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Abnormal oral glucose tolerance

MedGen UID:
339758
•Concept ID:
C1847425
•
Finding
Synonym: Abnormal glucose oral tolerance test
 
HPO: HP:0004924

Definition

An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral administration of glucose. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal oral glucose tolerance

Conditions with this feature

Congenital glucose-galactose malabsorption
MedGen UID:
78647
•Concept ID:
C0268186
•
Disease or Syndrome
Glucose/galactose malabsorption (GGM) is a rare autosomal recessive disorder caused by a defect in glucose and galactose transport across the intestinal brush border. Patients with GGM present with neonatal onset of severe life-threatening watery diarrhea and dehydration. If diagnosed and treated properly, patients can fully recover and show normal growth and development (summary by Xin and Wang, 2011).
See: Condition Record
Optic atrophy--spastic paraplegia syndrome
MedGen UID:
326914
•Concept ID:
C1839565
•
Disease or Syndrome
See: Condition Record
Congenital glucose-galactose malabsorption
Optic atrophy--spastic paraplegia syndrome

Professional guidelines

PubMed

Screening and diagnosing gestational diabetes mellitus.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article
The clinical utility of oral glucose tolerance test at term: can it predict fetal macrosomia?
Geifman-Holtzman O, Machtinger R, Spiliopoulos M, Schiff E, Koren-Morag N, Dulitzki M
Arch Gynecol Obstet 2010 May;281(5):817-21. Epub 2009 Jul 11 doi: 10.1007/s00404-009-1160-7. PMID: 19593579
Classification and diagnostic criteria for diabetes mellitus and other categories of glucose intolerance.
Harris MI
Prim Care 1988 Jun;15(2):205-25. PMID: 3290916

Recent clinical studies

Etiology

Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies.
Carlson AL, Beck RW, Li Z, Norton E, Bergenstal RM, Johnson M, Dunnigan S, Banfield M, Krumwiede KJ, Sibayan JR, Calhoun P, Durnwald C
BMJ Open Diabetes Res Care 2024 May 10;12(3) doi: 10.1136/bmjdrc-2023-003989. PMID: 38729771Free PMC Article
Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values.
Kotzaeridi G, Blätter J, Eppel D, Rosicky I, Linder T, Geissler F, Huhn EA, Hösli I, Tura A, Göbl CS
Eur J Clin Invest 2021 Sep;51(9):e13628. Epub 2021 Jun 13 doi: 10.1111/eci.13628. PMID: 34120352Free PMC Article
Oral glucose tolerance test for suspected late onset gestational diabetes.
Mohr Sasson A, Shats M, Goichberg Z, Mazaki-Tovi S, Morag I, Hendler I
J Matern Fetal Neonatal Med 2021 Dec;34(23):3928-3932. Epub 2019 Dec 18 doi: 10.1080/14767058.2019.1702945. PMID: 31851555
Third trimester abnormal oral glucose tolerance test and adverse perinatal outcome.
Arbib N, Gabbay-Benziv R, Aviram A, Sneh-Arbib O, Wiznitzer A, Hod M, Chen R, Hadar E
J Matern Fetal Neonatal Med 2017 Apr;30(8):917-921. Epub 2016 Jun 8 doi: 10.1080/14767058.2016.1190825. PMID: 27186963
Screening and diagnosing gestational diabetes mellitus.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article

Diagnosis

Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies.
Carlson AL, Beck RW, Li Z, Norton E, Bergenstal RM, Johnson M, Dunnigan S, Banfield M, Krumwiede KJ, Sibayan JR, Calhoun P, Durnwald C
BMJ Open Diabetes Res Care 2024 May 10;12(3) doi: 10.1136/bmjdrc-2023-003989. PMID: 38729771Free PMC Article
Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values.
Kotzaeridi G, Blätter J, Eppel D, Rosicky I, Linder T, Geissler F, Huhn EA, Hösli I, Tura A, Göbl CS
Eur J Clin Invest 2021 Sep;51(9):e13628. Epub 2021 Jun 13 doi: 10.1111/eci.13628. PMID: 34120352Free PMC Article
Oral glucose tolerance test for suspected late onset gestational diabetes.
Mohr Sasson A, Shats M, Goichberg Z, Mazaki-Tovi S, Morag I, Hendler I
J Matern Fetal Neonatal Med 2021 Dec;34(23):3928-3932. Epub 2019 Dec 18 doi: 10.1080/14767058.2019.1702945. PMID: 31851555
Third trimester abnormal oral glucose tolerance test and adverse perinatal outcome.
Arbib N, Gabbay-Benziv R, Aviram A, Sneh-Arbib O, Wiznitzer A, Hod M, Chen R, Hadar E
J Matern Fetal Neonatal Med 2017 Apr;30(8):917-921. Epub 2016 Jun 8 doi: 10.1080/14767058.2016.1190825. PMID: 27186963
Screening and diagnosing gestational diabetes mellitus.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article

Therapy

Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values.
Kotzaeridi G, Blätter J, Eppel D, Rosicky I, Linder T, Geissler F, Huhn EA, Hösli I, Tura A, Göbl CS
Eur J Clin Invest 2021 Sep;51(9):e13628. Epub 2021 Jun 13 doi: 10.1111/eci.13628. PMID: 34120352Free PMC Article
Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following Oesophageal Atresia Repair.
Aumar M, Gottrand F, Chalouhi C, Blanc S, Thomassin N, Piloquet H, Gastineau S, Schneider A, Krishnan U, Duvoisin G, Turck D, Coopman S, Michaud L
J Pediatr Gastroenterol Nutr 2020 Jun;70(6):820-824. doi: 10.1097/MPG.0000000000002651. PMID: 32443041
Screening and diagnosing gestational diabetes mellitus.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article
The relationship of one abnormal glucose tolerance test value and pregnancy complications.
Lindsay MK, Graves W, Klein L
Obstet Gynecol 1989 Jan;73(1):103-6. PMID: 2909030
Interpretation of an abnormal oral glucose tolerance test encountered during multiphasic laboratory screening.
Troxler RG, Trabal JF, Lancaster MC
Aviat Space Environ Med 1975 May;46(5):729-35. PMID: 1131139

Prognosis

Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies.
Carlson AL, Beck RW, Li Z, Norton E, Bergenstal RM, Johnson M, Dunnigan S, Banfield M, Krumwiede KJ, Sibayan JR, Calhoun P, Durnwald C
BMJ Open Diabetes Res Care 2024 May 10;12(3) doi: 10.1136/bmjdrc-2023-003989. PMID: 38729771Free PMC Article
Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following Oesophageal Atresia Repair.
Aumar M, Gottrand F, Chalouhi C, Blanc S, Thomassin N, Piloquet H, Gastineau S, Schneider A, Krishnan U, Duvoisin G, Turck D, Coopman S, Michaud L
J Pediatr Gastroenterol Nutr 2020 Jun;70(6):820-824. doi: 10.1097/MPG.0000000000002651. PMID: 32443041
Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests.
Sanda S; Type 1 Diabetes TrialNet Study Group
Pediatr Diabetes 2018 Mar;19(2):271-276. Epub 2017 Jul 14 doi: 10.1111/pedi.12542. PMID: 28707353Free PMC Article
Homeostatic model assessment of beta cell function predicting abnormal oral glucose tolerance testing in pregnancy: a systematic review and meta-analysis.
Ellerbrock J, Bohnen JMHA, Lopes van Balen VA, Mulder EG, Aardenburg R, Spaanderman MEA
Gynecol Endocrinol 2017 Dec;33(12):911-917. Epub 2017 Aug 28 doi: 10.1080/09513590.2017.1369516. PMID: 28846055
Screening and diagnosing gestational diabetes mellitus.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article

Clinical prediction guides

Glucose levels measured with continuous glucose monitoring in uncomplicated pregnancies.
Carlson AL, Beck RW, Li Z, Norton E, Bergenstal RM, Johnson M, Dunnigan S, Banfield M, Krumwiede KJ, Sibayan JR, Calhoun P, Durnwald C
BMJ Open Diabetes Res Care 2024 May 10;12(3) doi: 10.1136/bmjdrc-2023-003989. PMID: 38729771Free PMC Article
Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values.
Kotzaeridi G, Blätter J, Eppel D, Rosicky I, Linder T, Geissler F, Huhn EA, Hösli I, Tura A, Göbl CS
Eur J Clin Invest 2021 Sep;51(9):e13628. Epub 2021 Jun 13 doi: 10.1111/eci.13628. PMID: 34120352Free PMC Article
Oral glucose tolerance test for suspected late onset gestational diabetes.
Mohr Sasson A, Shats M, Goichberg Z, Mazaki-Tovi S, Morag I, Hendler I
J Matern Fetal Neonatal Med 2021 Dec;34(23):3928-3932. Epub 2019 Dec 18 doi: 10.1080/14767058.2019.1702945. PMID: 31851555
Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following Oesophageal Atresia Repair.
Aumar M, Gottrand F, Chalouhi C, Blanc S, Thomassin N, Piloquet H, Gastineau S, Schneider A, Krishnan U, Duvoisin G, Turck D, Coopman S, Michaud L
J Pediatr Gastroenterol Nutr 2020 Jun;70(6):820-824. doi: 10.1097/MPG.0000000000002651. PMID: 32443041
Screening and diagnosing gestational diabetes mellitus.
Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L
Evid Rep Technol Assess (Full Rep) 2012 Oct;(210):1-327. PMID: 24423035Free PMC Article

Recent systematic reviews

Homeostatic model assessment of beta cell function predicting abnormal oral glucose tolerance testing in pregnancy: a systematic review and meta-analysis.
Ellerbrock J, Bohnen JMHA, Lopes van Balen VA, Mulder EG, Aardenburg R, Spaanderman MEA
Gynecol Endocrinol 2017 Dec;33(12):911-917. Epub 2017 Aug 28 doi: 10.1080/09513590.2017.1369516. PMID: 28846055

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