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Delayed femoral head ossification

MedGen UID:
375891
•Concept ID:
C1846446
•
Finding
Synonym: Delayed maturation of the head of the thigh bone
 
HPO: HP:0008829

Definition

Delayed ossification of the femoral head. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelayed femoral head ossification

Conditions with this feature

Smith-McCort dysplasia 1
MedGen UID:
854757
•Concept ID:
C3888088
•
Disease or Syndrome
Any Smith-McCort dysplasia in which the cause of the disease is a mutation in the DYM gene.
See: Condition Record
Smith-McCort dysplasia 1

Professional guidelines

PubMed

Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review.
Lau RL, Perruccio AV, Evans HM, Mahomed SR, Mahomed NN, Gandhi R
BMC Musculoskelet Disord 2014 May 16;15:156. doi: 10.1186/1471-2474-15-156. PMID: 24886648Free PMC Article
Meyer's dysplasia : delayed ossification of the femoral head as a differential diagnosis in perthes' disease.
Muzaffar N, Song HR, Devmurari K, Modi H
Acta Orthop Belg 2010 Oct;76(5):608-12. PMID: 21138215
Experimentally gained insight - based proposal apropos the treatment of osteonecrosis of the femoral head.
Boss JH, Misselevich I, Bejar J, Norman D, Zinman C, Reis DN
Med Hypotheses 2004;62(6):958-65. doi: 10.1016/j.mehy.2003.12.036. PMID: 15142657

Recent clinical studies

Therapy

The fate of inverted limbus in children with developmental dysplasia of the hip: Clinical observation.
Liu J, Zhou W, Li L, Zhang L, Li Q, Wang E
J Orthop Res 2021 Jul;39(7):1433-1440. Epub 2020 Sep 28 doi: 10.1002/jor.24864. PMID: 32946117
Treatment of Unstable Slipped Capital Epiphysis Via the Modified Dunn Procedure.
Persinger F, Davis RL 2nd, Samora WP, Klingele KE
J Pediatr Orthop 2018 Jan;38(1):3-8. doi: 10.1097/BPO.0000000000000737. PMID: 26866640
Presence of the Ossific Nucleus and Risk of Osteonecrosis in the Treatment of Developmental Dysplasia of the Hip: A Meta-Analysis of Cohort and Case-Control Studies.
Chen C, Doyle S, Green D, Blanco J, Scher D, Sink E, Dodwell ER
J Bone Joint Surg Am 2017 May 3;99(9):760-767. doi: 10.2106/JBJS.16.00798. PMID: 28463920
Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review.
Lau RL, Perruccio AV, Evans HM, Mahomed SR, Mahomed NN, Gandhi R
BMC Musculoskelet Disord 2014 May 16;15:156. doi: 10.1186/1471-2474-15-156. PMID: 24886648Free PMC Article
A review of the treatment of hip dislocations associated with acetabular fractures.
Alonso JE, Volgas DA, Giordano V, Stannard JP
Clin Orthop Relat Res 2000 Aug;(377):32-43. doi: 10.1097/00003086-200008000-00007. PMID: 10943183

Prognosis

Surgical hip dislocation technique through the femoral head fovea fenestration and impaction bone grafting for the treatment of non-traumatic osteonecrosis of the femoral head: a retrospective study.
Liang D, Pei J, Zhang X, Pei R, Chen X
J Orthop Surg Res 2024 Jul 26;19(1):437. doi: 10.1186/s13018-024-04901-x. PMID: 39061096Free PMC Article
Delayed femoral artery injury caused by heterotopic ossification: a rare case report and review of the literature.
Li YH, Liu M, Zhou C, Tan L
BMC Musculoskelet Disord 2024 Jun 20;25(1):485. doi: 10.1186/s12891-024-07609-5. PMID: 38902664Free PMC Article
Risk Factors for the Development of Heterotopic Ossification Following Acetabular Fractures: A Systematic Review.
Yeung P, Zarnett O, Lefaivre KA, Guy P
JBJS Rev 2022 Sep 1;10(9) Epub 2022 Sep 22 doi: 10.2106/JBJS.RVW.20.00263. PMID: 36137013
Presence of the Ossific Nucleus and Risk of Osteonecrosis in the Treatment of Developmental Dysplasia of the Hip: A Meta-Analysis of Cohort and Case-Control Studies.
Chen C, Doyle S, Green D, Blanco J, Scher D, Sink E, Dodwell ER
J Bone Joint Surg Am 2017 May 3;99(9):760-767. doi: 10.2106/JBJS.16.00798. PMID: 28463920
Development of the hip in diastrophic dysplasia.
Vaara P, Peltonen J, Poussa M, Merikanto J, Nurminen M, Kaitila I, Ryöppy S
J Bone Joint Surg Br 1998 Mar;80(2):315-20. doi: 10.1302/0301-620x.80b2.8329. PMID: 9546468

Clinical prediction guides

Case report of a delayed iatrogenic Pipkin type III femoral head fracture-dislocation.
Li QW, Zhou CS, Li YP
Medicine (Baltimore) 2022 Jan 28;101(4):e28773. doi: 10.1097/MD.0000000000028773. PMID: 35089256Free PMC Article
The fate of inverted limbus in children with developmental dysplasia of the hip: Clinical observation.
Liu J, Zhou W, Li L, Zhang L, Li Q, Wang E
J Orthop Res 2021 Jul;39(7):1433-1440. Epub 2020 Sep 28 doi: 10.1002/jor.24864. PMID: 32946117
A novel COMP mutation in a Chinese family with multiple epiphyseal dysplasia.
Shao J, Zhao S, Yan Z, Wang L, Zhang Y, Lin M, Yu C, Wang S, Niu Y, Li X, Qiu G, Zhang J; Deciphering Disorders Involving Scoliosis and COmorbidities (DISCO) study, Wu Z, Wu N
BMC Med Genet 2020 May 27;21(1):115. doi: 10.1186/s12881-020-01040-y. PMID: 32460719Free PMC Article
Association between the ossific nucleus and osteonecrosis in treating developmental dysplasia of the Hip: updated meta-analysis.
Niziol R, Elvey M, Protopapa E, Roposch A
BMC Musculoskelet Disord 2017 Apr 20;18(1):165. doi: 10.1186/s12891-017-1468-6. PMID: 28427427Free PMC Article
A review of the treatment of hip dislocations associated with acetabular fractures.
Alonso JE, Volgas DA, Giordano V, Stannard JP
Clin Orthop Relat Res 2000 Aug;(377):32-43. doi: 10.1097/00003086-200008000-00007. PMID: 10943183

Recent systematic reviews

Risk Factors for the Development of Heterotopic Ossification Following Acetabular Fractures: A Systematic Review.
Yeung P, Zarnett O, Lefaivre KA, Guy P
JBJS Rev 2022 Sep 1;10(9) Epub 2022 Sep 22 doi: 10.2106/JBJS.RVW.20.00263. PMID: 36137013
Association between the ossific nucleus and osteonecrosis in treating developmental dysplasia of the Hip: updated meta-analysis.
Niziol R, Elvey M, Protopapa E, Roposch A
BMC Musculoskelet Disord 2017 Apr 20;18(1):165. doi: 10.1186/s12891-017-1468-6. PMID: 28427427Free PMC Article
Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review.
Lau RL, Perruccio AV, Evans HM, Mahomed SR, Mahomed NN, Gandhi R
BMC Musculoskelet Disord 2014 May 16;15:156. doi: 10.1186/1471-2474-15-156. PMID: 24886648Free PMC Article

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