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Schizophrenia 11(SCZD11)

MedGen UID:
334205
•Concept ID:
C1842605
•
Disease or Syndrome
Synonyms: SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 10q-RELATED; SCZD11
 
Monarch Initiative: MONDO:0011960
OMIM®: 608078

Definition

A schizophrenia that has material basis in a mutation on chromosome 10q22.3. [from MONDO]

Professional guidelines

PubMed

Validity, reliability and clinical utility of mental disorders: The case of ICD-11 schizophrenia.
Valle R
Rev Colomb Psiquiatr (Engl Ed) 2022 Jan-Mar;51(1):61-70. Epub 2022 Feb 21 doi: 10.1016/j.rcpeng.2020.09.003. PMID: 35210207
Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis.
Noto C, Ota VK, Santoro ML, Gouvea ES, Silva PN, Spindola LM, Cordeiro Q, Bressan RA, Gadelha A, Brietzke E, Belangero SI, Maes M
Mol Neurobiol 2016 Oct;53(8):5701-9. Epub 2015 Oct 22 doi: 10.1007/s12035-015-9489-3. PMID: 26491028

Recent clinical studies

Therapy

A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Maintenance Treatment in Adults with Schizophrenia.
Forbes A, Hobart M, Ouyang J, Shi L, Pfister S, Hakala M
Int J Neuropsychopharmacol 2018 May 1;21(5):433-441. doi: 10.1093/ijnp/pyy002. PMID: 29415258Free PMC Article
Effect of clozapine on serum leptin, insulin levels, and body weight and composition in patients with schizophrenia.
Kivircik BB, Alptekin K, Calişkan S, Cömlekçi A, Orük G, Tümüklü M, Kürklü K, Arkar H, Türk A, Calişkan M, Yeşil S
Prog Neuropsychopharmacol Biol Psychiatry 2003 Aug;27(5):795-9. doi: 10.1016/S0278-5846(03)00111-8. PMID: 12921912
Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia.
Falke E, Han LY, Arnold SE
Psychiatry Res 2000 Mar 6;93(2):103-10. doi: 10.1016/s0165-1781(00)00104-9. PMID: 10725527
Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia.
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544
An evaluation of community-based psychiatric care for people with treated long-term mental illness.
Wilkinson G, Piccinelli M, Falloon I, Krekorian H, McLees S
Br J Psychiatry 1995 Jul;167(1):26-37; discussion 38-40. doi: 10.1192/bjp.167.1.26. PMID: 7551605

Prognosis

Exome Sequencing of Familial Bipolar Disorder.
Goes FS, Pirooznia M, Parla JS, Kramer M, Ghiban E, Mavruk S, Chen YC, Monson ET, Willour VL, Karchin R, Flickinger M, Locke AE, Levy SE, Scott LJ, Boehnke M, Stahl E, Moran JL, Hultman CM, Landén M, Purcell SM, Sklar P, Zandi PP, McCombie WR, Potash JB
JAMA Psychiatry 2016 Jun 1;73(6):590-7. doi: 10.1001/jamapsychiatry.2016.0251. PMID: 27120077Free PMC Article
Association between alcohol and substance use disorders and all-cause and cause-specific mortality in schizophrenia, bipolar disorder, and unipolar depression: a nationwide, prospective, register-based study.
Hjorthøj C, Østergaard ML, Benros ME, Toftdahl NG, Erlangsen A, Andersen JT, Nordentoft M
Lancet Psychiatry 2015 Sep;2(9):801-8. Epub 2015 Aug 12 doi: 10.1016/S2215-0366(15)00207-2. PMID: 26277044
Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder.
Killgore WD, Rosso IM, Gruber SA, Yurgelun-Todd DA
Cogn Behav Neurol 2009 Mar;22(1):28-37. doi: 10.1097/WNN.0b013e318192cc67. PMID: 19372768
Psychiatric illness and adverse pregnancy outcome.
Schneid-Kofman N, Sheiner E, Levy A
Int J Gynaecol Obstet 2008 Apr;101(1):53-6. Epub 2007 Dec 20 doi: 10.1016/j.ijgo.2007.10.007. PMID: 18082746
Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia.
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544

Clinical prediction guides

Substance use and self-poisoning in schizophrenia: 11-year findings from a national clinical survey of suicide in mental health patients in the UK.
Mulligan LD, Bojanić L, Hunt IM, Baird A, Turnbull P, Kapur N, Appleby L, Shaw J
Schizophr Res 2024 May;267:254-260. Epub 2024 Apr 5 doi: 10.1016/j.schres.2024.03.048. PMID: 38581828
Hair cortisol levels in schizophrenia and metabolic syndrome.
van den Heuvel LL, Smit AM, Stalder T, Kirschbaum C, Seedat S, Emsley R
Early Interv Psychiatry 2022 Aug;16(8):902-911. Epub 2022 Jan 3 doi: 10.1111/eip.13238. PMID: 34978366
Trends in Public Stigma of Mental Illness in the US, 1996-2018.
Pescosolido BA, Halpern-Manners A, Luo L, Perry B
JAMA Netw Open 2021 Dec 1;4(12):e2140202. doi: 10.1001/jamanetworkopen.2021.40202. PMID: 34932103Free PMC Article
Cognition and physical functioning in patients with schizophrenia: any role for vitamin D?
Zoghbi M, Haddad C, Hallit S, Nabout R, Medlej-Hashim M, Hachem D, Azar J
Nutr Neurosci 2020 Nov;23(11):911-919. Epub 2019 Feb 17 doi: 10.1080/1028415X.2019.1580830. PMID: 30774039
Exome Sequencing of Familial Bipolar Disorder.
Goes FS, Pirooznia M, Parla JS, Kramer M, Ghiban E, Mavruk S, Chen YC, Monson ET, Willour VL, Karchin R, Flickinger M, Locke AE, Levy SE, Scott LJ, Boehnke M, Stahl E, Moran JL, Hultman CM, Landén M, Purcell SM, Sklar P, Zandi PP, McCombie WR, Potash JB
JAMA Psychiatry 2016 Jun 1;73(6):590-7. doi: 10.1001/jamapsychiatry.2016.0251. PMID: 27120077Free PMC Article

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