Major affective disorder 2(MAFD2)

MedGen UID:: 326975
•Concept ID:: C1839839
•: Mental or Behavioral Dysfunction

Synonyms:	MAFD2; MANIC-DEPRESSIVE ILLNESS; MANIC-DEPRESSIVE PSYCHOSIS, X-LINKED

Monarch Initiative:	MONDO:0010648
OMIM®:	309200

Clinical features

From HPO

Bipolar affective disorder

MedGen UID:: 2649
•Concept ID:: C0005586
•: Mental or Behavioral Dysfunction

Bipolar disorder is an illness of mood characterized by alternating episodes of elevated and depressed moods, which are interspersed with euthymic periods.

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Abnormality of the nervous system
- Bipolar affective disorder

Professional guidelines

PubMed

Depressive mixed states: A reappraisal of Koukopoulos' criteria.

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

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Curated

UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

Recent clinical studies

Etiology

Empirical validity of Leonhard's psychoses: A long-term follow-up study of first-episode psychosis patients.

Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995

Philipp Jolly and his 1913 "the heredity of psychosis": Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic-depressive illness and dementia praecox.

Kendler KS, Klee A
Am J Med Genet B Neuropsychiatr Genet 2021 Mar;186(2):90-100. Epub 2021 Jan 22 doi: 10.1002/ajmg.b.32831. PMID: 33484094

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Diagnosis

Kraepelin's final views on manic-depressive Illness.

Kendler KS
J Affect Disord 2021 Mar 1;282:979-990. Epub 2021 Jan 6 doi: 10.1016/j.jad.2020.12.200. PMID: 33601743

Dreyfus and the shift of melancholia in Kraepelin's textbooks from an involutional to a manic-depressive illness.

Kendler KS, Engstrom EJ
J Affect Disord 2020 Jun 1;270:42-50. Epub 2020 Mar 29 doi: 10.1016/j.jad.2020.03.094. PMID: 32275219

The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900.

Kendler KS
Mol Psychiatry 2017 Nov;22(11):1539-1553. Epub 2017 Aug 8 doi: 10.1038/mp.2017.148. PMID: 28785109

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness.

Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114 Free PMC Article

Depressive mixed states: A reappraisal of Koukopoulos' criteria.

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

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Therapy

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness.

Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114 Free PMC Article

Depressive mixed states: A reappraisal of Koukopoulos' criteria.

Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Prescribing patterns of antidepressants, antipsychotics and mood stabilizers in bipolar patients misdiagnosed with major depressive disorder in China.

Xiang YT, Hu C, Wang G, Zheng QW, Fang YR, Ungvari GS, Kilbourne AM, Lai KY, Si TM, Chen DF, Lu Z, Yang HC, Hu J, Chen ZY, Huang Y, Sun J, Wang XP, Li HC, Zhang JB, Chiu HF
Hum Psychopharmacol 2012 Nov;27(6):626-31. Epub 2012 Oct 2 doi: 10.1002/hup.2262. PMID: 23027671

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