U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Muscle stiffness, painful

MedGen UID:
325522
•Concept ID:
C1838818
•
Finding
Synonym: MUSCLE STIFFNESS, PAINFUL
 
OMIM®: 590050

Professional guidelines

PubMed

Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review.
Katz JN, Arant KR, Loeser RF
JAMA 2021 Feb 9;325(6):568-578. doi: 10.1001/jama.2020.22171. PMID: 33560326Free PMC Article
Guidelines on clinical presentation and management of nondystrophic myotonias.
Stunnenberg BC, LoRusso S, Arnold WD, Barohn RJ, Cannon SC, Fontaine B, Griggs RC, Hanna MG, Matthews E, Meola G, Sansone VA, Trivedi JR, van Engelen BGM, Vicart S, Statland JM
Muscle Nerve 2020 Oct;62(4):430-444. Epub 2020 May 27 doi: 10.1002/mus.26887. PMID: 32270509Free PMC Article
Advances in Delayed-Onset Muscle Soreness (DOMS) - Part II: Treatment and Prevention.
Heiss R, Lutter C, Freiwald J, Hoppe MW, Grim C, Poettgen K, Forst R, Bloch W, Hüttel M, Hotfiel T
Sportverletz Sportschaden 2019 Mar;33(1):21-29. Epub 2019 Mar 13 doi: 10.1055/a-0810-3516. PMID: 30865998

Recent clinical studies

Etiology

Therapies in Stiff-Person Syndrome: Advances and Future Prospects Based on Disease Pathophysiology.
Dalakas MC
Neurol Neuroimmunol Neuroinflamm 2023 May;10(3) Epub 2023 Apr 14 doi: 10.1212/NXI.0000000000200109. PMID: 37059468Free PMC Article
Cervical and scapula-focused resistance exercise program versus trapezius massage in patients with chronic neck pain: A randomized controlled trial.
Kang T, Kim B
Medicine (Baltimore) 2022 Sep 30;101(39):e30887. doi: 10.1097/MD.0000000000030887. PMID: 36181044Free PMC Article
Back Pain in Children and Adolescents.
Achar S, Yamanaka J
Am Fam Physician 2020 Jul 1;102(1):19-28. PMID: 32603067
Manipulative Therapies: What Works.
Smith MS, Olivas J, Smith K
Am Fam Physician 2019 Feb 15;99(4):248-252. PMID: 30763049
Muscle stretching exercises and resistance training in fibromyalgia: which is better? A three-arm randomized controlled trial.
Assumpção A, Matsutani LA, Yuan SL, Santo AS, Sauer J, Mango P, Marques AP
Eur J Phys Rehabil Med 2018 Oct;54(5):663-670. Epub 2017 Nov 29 doi: 10.23736/S1973-9087.17.04876-6. PMID: 29185675

Diagnosis

Therapies in Stiff-Person Syndrome: Advances and Future Prospects Based on Disease Pathophysiology.
Dalakas MC
Neurol Neuroimmunol Neuroinflamm 2023 May;10(3) Epub 2023 Apr 14 doi: 10.1212/NXI.0000000000200109. PMID: 37059468Free PMC Article
Back Pain in Children and Adolescents.
Achar S, Yamanaka J
Am Fam Physician 2020 Jul 1;102(1):19-28. PMID: 32603067
Guidelines on clinical presentation and management of nondystrophic myotonias.
Stunnenberg BC, LoRusso S, Arnold WD, Barohn RJ, Cannon SC, Fontaine B, Griggs RC, Hanna MG, Matthews E, Meola G, Sansone VA, Trivedi JR, van Engelen BGM, Vicart S, Statland JM
Muscle Nerve 2020 Oct;62(4):430-444. Epub 2020 May 27 doi: 10.1002/mus.26887. PMID: 32270509Free PMC Article
Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics.
Hotfiel T, Freiwald J, Hoppe MW, Lutter C, Forst R, Grim C, Bloch W, Hüttel M, Heiss R
Sportverletz Sportschaden 2018 Dec;32(4):243-250. Epub 2018 Dec 11 doi: 10.1055/a-0753-1884. PMID: 30537791
Stiff person syndrome.
Hadavi S, Noyce AJ, Leslie RD, Giovannoni G
Pract Neurol 2011 Oct;11(5):272-82. doi: 10.1136/practneurol-2011-000071. PMID: 21921002

Therapy

Therapies in Stiff-Person Syndrome: Advances and Future Prospects Based on Disease Pathophysiology.
Dalakas MC
Neurol Neuroimmunol Neuroinflamm 2023 May;10(3) Epub 2023 Apr 14 doi: 10.1212/NXI.0000000000200109. PMID: 37059468Free PMC Article
Cervical and scapula-focused resistance exercise program versus trapezius massage in patients with chronic neck pain: A randomized controlled trial.
Kang T, Kim B
Medicine (Baltimore) 2022 Sep 30;101(39):e30887. doi: 10.1097/MD.0000000000030887. PMID: 36181044Free PMC Article
Guidelines on clinical presentation and management of nondystrophic myotonias.
Stunnenberg BC, LoRusso S, Arnold WD, Barohn RJ, Cannon SC, Fontaine B, Griggs RC, Hanna MG, Matthews E, Meola G, Sansone VA, Trivedi JR, van Engelen BGM, Vicart S, Statland JM
Muscle Nerve 2020 Oct;62(4):430-444. Epub 2020 May 27 doi: 10.1002/mus.26887. PMID: 32270509Free PMC Article
Manipulative Therapies: What Works.
Smith MS, Olivas J, Smith K
Am Fam Physician 2019 Feb 15;99(4):248-252. PMID: 30763049
Stiff person syndrome.
Hadavi S, Noyce AJ, Leslie RD, Giovannoni G
Pract Neurol 2011 Oct;11(5):272-82. doi: 10.1136/practneurol-2011-000071. PMID: 21921002

Prognosis

The benefits of physical therapy in juvenile idiopathic arthritis.
Di Ludovico A, La Bella S, Di Donato G, Felt J, Chiarelli F, Breda L
Rheumatol Int 2023 Sep;43(9):1563-1572. Epub 2023 Jun 29 doi: 10.1007/s00296-023-05380-9. PMID: 37382676
Frozen shoulder.
Millar NL, Meakins A, Struyf F, Willmore E, Campbell AL, Kirwan PD, Akbar M, Moore L, Ronquillo JC, Murrell GAC, Rodeo SA
Nat Rev Dis Primers 2022 Sep 8;8(1):59. doi: 10.1038/s41572-022-00386-2. PMID: 36075904
SPS: Understanding the complexity.
El-Abassi R, Soliman MY, Villemarette-Pittman N, England JD
J Neurol Sci 2019 Sep 15;404:137-149. Epub 2019 Jul 17 doi: 10.1016/j.jns.2019.06.021. PMID: 31377632
Exercise-induced rhabdomyolysis.
Lee G
R I Med J (2013) 2014 Nov 3;97(11):22-4. PMID: 25365815
Functional exercise after total hip replacement (FEATHER): a randomised control trial.
Monaghan B, Grant T, Hing W, Cusack T
BMC Musculoskelet Disord 2012 Nov 28;13:237. doi: 10.1186/1471-2474-13-237. PMID: 23190932Free PMC Article

Clinical prediction guides

Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis.
Warneke K, Plöschberger G, Lohmann LH, Lichtenstein E, Jochum D, Siegel SD, Zech A, Behm DG
J Sport Health Sci 2024 Jul;13(4):509-520. Epub 2024 Jan 18 doi: 10.1016/j.jshs.2024.01.006. PMID: 38244921Free PMC Article
Cervical and scapula-focused resistance exercise program versus trapezius massage in patients with chronic neck pain: A randomized controlled trial.
Kang T, Kim B
Medicine (Baltimore) 2022 Sep 30;101(39):e30887. doi: 10.1097/MD.0000000000030887. PMID: 36181044Free PMC Article
The deep fascia and its role in chronic pain and pathological conditions: A review.
Kondrup F, Gaudreault N, Venne G
Clin Anat 2022 Jul;35(5):649-659. Epub 2022 Apr 27 doi: 10.1002/ca.23882. PMID: 35417568
Muscle stretching exercises and resistance training in fibromyalgia: which is better? A three-arm randomized controlled trial.
Assumpção A, Matsutani LA, Yuan SL, Santo AS, Sauer J, Mango P, Marques AP
Eur J Phys Rehabil Med 2018 Oct;54(5):663-670. Epub 2017 Nov 29 doi: 10.23736/S1973-9087.17.04876-6. PMID: 29185675
Stiff person syndrome.
Hadavi S, Noyce AJ, Leslie RD, Giovannoni G
Pract Neurol 2011 Oct;11(5):272-82. doi: 10.1136/practneurol-2011-000071. PMID: 21921002

Recent systematic reviews

Interventions for managing skeletal muscle spasticity following traumatic brain injury.
Synnot A, Chau M, Pitt V, O'Connor D, Gruen RL, Wasiak J, Clavisi O, Pattuwage L, Phillips K
Cochrane Database Syst Rev 2017 Nov 22;11(11):CD008929. doi: 10.1002/14651858.CD008929.pub2. PMID: 29165784Free PMC Article
Aerobic exercise training for adults with fibromyalgia.
Bidonde J, Busch AJ, Schachter CL, Overend TJ, Kim SY, Góes SM, Boden C, Foulds HJ
Cochrane Database Syst Rev 2017 Jun 21;6(6):CD012700. doi: 10.1002/14651858.CD012700. PMID: 28636204Free PMC Article
Polymyalgia Rheumatica and Giant Cell Arteritis: A Systematic Review.
Buttgereit F, Dejaco C, Matteson EL, Dasgupta B
JAMA 2016 Jun 14;315(22):2442-58. doi: 10.1001/jama.2016.5444. PMID: 27299619
Effects of self-myofascial release: A systematic review.
Beardsley C, Škarabot J
J Bodyw Mov Ther 2015 Oct;19(4):747-58. Epub 2015 Aug 28 doi: 10.1016/j.jbmt.2015.08.007. PMID: 26592233
Aquatic exercise training for fibromyalgia.
Bidonde J, Busch AJ, Webber SC, Schachter CL, Danyliw A, Overend TJ, Richards RS, Rader T
Cochrane Database Syst Rev 2014 Oct 28;2014(10):CD011336. doi: 10.1002/14651858.CD011336. PMID: 25350761Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...